Results 111 to 120 of about 304,542 (327)
eLifeCertain strains of a bacterium found in the gut of some animals, Lactobacillus plantarum, are able to counter hyperuricemia, a condition caused by high levels of uric acid in the blood.
Caihong Hu
doaj +1 more source
Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase.
Cell Reports, 2017 Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides.
N. Emmanuel +9 more
semanticscholar +1 more source
American Journal of Hematology, EarlyView.ABSTRACT In a large multicenter real‐world cohort, we aimed to evaluate outcomes of FLAG‐Ida salvage therapy for relapsed/refractory (R/R) acute myeloid leukemia (AML) and validated the SALFLAGE prognostic score. We analyzed 1079 adults with R/R AML treated across 112 PETHEMA institutions over 26 years (1998–2024), including patients with primary ...
Gaspar Aspas Requena +49 more
wiley +1 more source
FoodsHyperuricemia (HUA) is a metabolic disorder that can easily lead to gout or kidney disease, and it is believed that it can be treated effectively using probiotics.
Xiqian Tan +5 more
doaj +1 more source
Purine Phosphoribosyltransferases [PDF]
Journal of Biological Chemistry, 2000 S P, Craig, A E, Eakin
openaire +2 more sources
Gambaran Asupan Purin Pada Remaja Di Kabupaten Minahasa [PDF]
, 2013 : High purine intake can result in hyperuricemia which leads to gouthy arthritis and formation of kidney stone. High purine concentration is mainly contained in animal protein.
Ali, N. H. (Ningsi) +2 more
core
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
Nature Communications, 2017 Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the ...
Shaun Stairs +5 more
semanticscholar +1 more source
Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA
Angewandte Chemie, EarlyView.Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl +1 more
wiley +1 more source
Synthesis of purines and adenines containing the hexafluoroisopropyl group
Beilstein Journal of Organic Chemistry, 2020 Several new derivatives of adenine, purine, and theophylline containing the (CF3)2CH group connected to a nitrogen atom of the imidazole ring were prepared by the reaction of 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (1) with the corresponding ...
Viacheslav Petrov +5 more
doaj +1 more source
Emerging Role of Purine Metabolizing Enzymes in Brain Function and Tumors
International Journal of Molecular Sciences, 2018 The growing evidence of the involvement of purine compounds in signaling, of nucleotide imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light on purine metabolism, indicating that well known biochemical pathways may ...
M. Garcia-Gil +5 more
semanticscholar +1 more source