Results 131 to 140 of about 245,344 (350)

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance This study draws on the power of superresolution microscopy to investigate how metabolons behave near different subcellular components. We revealed an interdependent relationship among purinosomes, mitochondria, and microtubules.
Chung-Yu Chan, Anthony M. Pedley, Doory Kim, C. Xia, X. Zhuang, S. Benkovic   +5 more
semanticscholar   +1 more source

Rate of incorporation of radiolabeled leucine and uracil into purine-starved and purine-replete cells.

, 2014
The rate of incorporation of [4,5-3H]-leucine and [2-14C]-uracil was compared between purine-replete (open bars) and cells starved for purine for 24 h (closed bars).
Joshua F. Alfaro (528143), Kristin E. Burnum-Johnson (503747), Feng Yang (132135), David G. Camp II (218098), Jessica L. Martin (528140), Nicola S. Carter (528144), Phillip A. Yates (528141), Karl K. Weitz (243011), Radika Soysa (528142), Phillip A. Wilmarth (231403), Vladislav A. Petyuk (218084), Peter J. Myler (244412), Richard D. Smith (39311), Larry L. David (231405), Gowthaman Ramasamy (19191)   +14 more
core   +1 more source

Probiotics in Alleviating Hyperuricemia: Research Status, Mechanism of Action and Challenges

Shipin gongye ke-ji
Hyperuricemia (HUA) is a chronic metabolic disease, characterized by excessive uric acid in the blood, caused by purine metabolism disorders. Studies show that conventional clinical treatment methods have certain limitations, while probiotics have the ...
Xinru YANG, Jiayue TANG, Xiaoqun ZENG, Zhen WU, Qiwei DU, Maolin TU   +5 more
doaj   +1 more source

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

Nature Communications, 2017
Understanding prebiotic nucleotide synthesis is a long standing challenge thought to be essential to elucidating the origins of life on Earth. Recently, remarkable progress has been made, but to date all proposed syntheses account separately for the ...
Shaun Stairs, Arif Nikmal, Dejan-Krešimir Bučar, Shao-Liang Zheng, J. Szostak, M. Powner   +5 more
semanticscholar   +1 more source

Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation [PDF]

, 2011
Background: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis.
Jason Greenwald, Perozzo Remo, Greenwald Jason, Dirk Kostrewa, Leonardo Scapozza, Remo Perozzo, Kuettel Sabine, Perozzo, Remo, Shaheen Ahmed, Kostrewa Dirk, Scapozza Leonardo, Kuettel, Sabine, Greenwald, Jason, Scapozza, Leonardo, Ahmed Shaheen, Kostrewa, Dirk, Sabine Kuettel, Ahmed, Shaheen, Ahmed S, Perozzo, Remo (author), Kuettel, Sabine (author), Greenwald J, Kostrewa, Dirk (author), Ahmed, Shaheen (author), Perozzo R, Greenwald, Jason (author), Scapozza, Leonardo (author), Scapozza L, Kuettel S, Kostrewa D   +29 more
core   +2 more sources

Synthesis, Antiproliferative Activity, and ADME Profiling of Novel Racemic and Optically Pure Aryl-Substituted Purines and Purine Bioisosteres

Biomolecules
The aim of this study was to synthesize new racemic and optically pure aryl-substituted purine bioisosteres using ultrasound-assisted Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition.
Martina Piškor, Astrid Milić, Sanja Koštrun, Maja Majerić Elenkov, Petra Grbčić, Sandra Kraljević Pavelić, Krešimir Pavelić, Silvana Raić-Malić   +7 more
doaj   +1 more source

Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

Food Science and Human Wellness
Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment.
Peijun Tian, Yunfei Hou, Zheng Wang, Jiaona Jiang, Xin Qian, Zhihao Qu, Jianxin Zhao, Gang Wang, Wei Chen   +8 more
doaj   +1 more source

Derivatives of 2,6-Diazidopurine and 2,6-Bis-(1,2,3-Triazol-1-yl) Purine as Useful Intermediates in the Synthesis of Modified Purine Nucleosides

Novel 2,6-bis-(1,2,3-triazol-1-yl)purine, N6-substituted-2-(1,2,3-triazol-1-yl)adenine and 6-alkyl/arylthio-2-(1,2,3-triazol-1-yl)purine and 2-alkylthio-6-(1,2,3-triazol-1-yl)purine nucleosides were synthesized.
Bizdēna, Ērika, Novosjolova, Irina, Turks, Māris   +2 more
core  

Purine

, 2004
Inelastic Neutron Scattering spectrum of Purine, C₅H₄N₄, measured on the TOSCA ...
S.F. Parker, ISIS Facility
core   +1 more source