Results 121 to 130 of about 304,542 (327)

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Probiotics in Alleviating Hyperuricemia: Research Status, Mechanism of Action and Challenges

Shipin gongye ke-ji
Hyperuricemia (HUA) is a chronic metabolic disease, characterized by excessive uric acid in the blood, caused by purine metabolism disorders. Studies show that conventional clinical treatment methods have certain limitations, while probiotics have the ...
Xinru YANG, Jiayue TANG, Xiaoqun ZENG, Zhen WU, Qiwei DU, Maolin TU   +5 more
doaj   +1 more source

Analyses of pyrimidine and purine bases by a combination of paper chromatography and time of flight mass spectrometry [PDF]

Paper chromatography and mass spectrometry for analyses of pyrimidine and purine ...
Fuse, K., Hayatsu, R., Studier, M. H.
core   +1 more source

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source

Synthesis, Antiproliferative Activity, and ADME Profiling of Novel Racemic and Optically Pure Aryl-Substituted Purines and Purine Bioisosteres

Biomolecules
The aim of this study was to synthesize new racemic and optically pure aryl-substituted purine bioisosteres using ultrasound-assisted Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition.
Martina Piškor, Astrid Milić, Sanja Koštrun, Maja Majerić Elenkov, Petra Grbčić, Sandra Kraljević Pavelić, Krešimir Pavelić, Silvana Raić-Malić   +7 more
doaj   +1 more source

Effects of strand and directional asymmetry on base-base coupling and charge transfer in double-helical DNA [PDF]

, 2002
Mechanistic models of charge transfer (CT) in macromolecules often focus on CT energetics and distance as the chief parameters governing CT rates and efficiencies.
Barton, Jacqueline K., O'Neill, Melanie A.   +1 more
core  

Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity

Molecular Metabolism, 2017
Objective Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition.
T. Fromme, Karin Kleigrewe, A. Dunkel, Angelika Retzler, Yongguo Li, Stefanie Maurer, N. Fischer, R. Diezko, T. Kanzleiter, Verena Hirschberg, T. Hofmann, M. Klingenspor   +11 more
semanticscholar   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

Food Science and Human Wellness
Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment.
Peijun Tian, Yunfei Hou, Zheng Wang, Jiaona Jiang, Xin Qian, Zhihao Qu, Jianxin Zhao, Gang Wang, Wei Chen   +8 more
doaj   +1 more source

Allantoin, a stress-related purine metabolite, can activate jasmonate signaling in a MYC2-regulated and abscisic acid-dependent manner

Journal of Experimental Botany, 2016
Highlight Allantoin, a stress-related purine metabolite, can activate JA responses via ABA in Arabidopsis, suggesting its possible involvement in the homeostasis of these phytohormones and their interplay in stress signaling.
H. Takagi, Y. Ishiga, Shunsuke Watanabe, T. Konishi, M. Egusa, Nobuhiro Akiyoshi, Takakazu Matsuura, I. Mori, T. Hirayama, H. Kaminaka, H. Shimada, A. Sakamoto   +11 more
semanticscholar   +1 more source