Results 121 to 130 of about 157,697 (307)
Synthesis of 2,6-Bis-(1,2,3-Triazolyl)-Substituted Purine Nucleosides
Synthesis and chemical reactivity of novel type of bis-triazolyl purine nucleosides is ...
Bizdēna, Ērika +2 more
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Ubiquitous purine sensor modulates diverse signal transduction pathways in bacteria [PDF]
Purines and their derivatives control intracellular energy homeostasis and nucleotide synthesis, and act as signaling molecules. Here, we combine structural and sequence information to define a purine-binding motif that is present in sensor domains of
Monteagudo-Cascales, Elizabet +11 more
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Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
2,6-Bis-(1,2,3-Triazolyl)-Purine Nucleosides and Their Reactivity towards Different Nucleophiles
In this study the synthesis of bistriazolyl purine nucleosides was accomplished in copper (I) catalyzed “click” reactions with different alkynes. Bistriazolyl derivatives have been exposed to nucleophilic attack with different amines and thioles, and ...
Beļakovs, Sergejs +3 more
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Developmental Dynamics, EarlyView.Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard +3 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Application of Triazolyl Purine Derivatives in Nucleophilic Aromatic Substitution Reactions
The synthesis and applications of novel bis-triazolyl purine derivatives are ...
Novosjolova, Irina
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Estudos de relações preditivas entre a estrutura e a atividade para inibição enzimática e analgesia / [PDF]
, 1999 Tese (Doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e ...
Andricopulo, Adriano Defini
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Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source