Results 151 to 160 of about 245,344 (350)
Synthesis and Properties of Triazolyl Purine Nucleosides
A novel class of bis-triazolyl purine nucleosides was obtained and triazolyl moiety at C(6) of the purine base undergoes a facile nucleophilic heteroaromatic substitution with N- and S-nucleophiles.
Novosjolova, Irina
core
Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics
Animal Research and One Health, EarlyView.Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley +1 more source
The purine path to chemotherapy
In Vitro Cellular & Developmental Biology, 1989 Antimetabolites of purine metabolism have found a use as anti-leukaemic, antiprotozoal and antiviral drugs, in immunosuppression and transplantation, and in gout and hyperuricemia. Their mechanisms of action are reviewed.
openaire +2 more sources
Synthesis of 2,6-Bis-(1,2,3-Triazolyl)-Substituted Purine Nucleosides
Synthesis and chemical reactivity of novel type of bis-triazolyl purine nucleosides is ...
Bizdēna, Ērika +2 more
core
Antimycobacterial Agents. 1. Thio Analogues of Purine†
, 2016 Thio analogues of purine, pyridine, and pyrimidine were prepared based on the initial activity screening of several analogues of these heterocycles against Mycobacterium tuberculosis (Mtb).
Vibha Pathak (172306) +4 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Graphical Abstract Objective This study aimed to characterize whole blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or B lymphocyte stimulator/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to nonresponse. Methods Whole blood RNA sequencing was performed
Aimen Ibrahim +9 more
wiley +1 more source
Application of Triazolyl Purine Derivatives in Nucleophilic Aromatic Substitution Reactions
The synthesis and applications of novel bis-triazolyl purine derivatives are ...
Novosjolova, Irina
core
2,6-Bis-(1,2,3-Triazolyl)-Purine Nucleosides and Their Reactivity towards Different Nucleophiles
A synthesis and applications of a novel class of bis-triazolyl purine nucleosides are described and the physical properties of obtained compounds are ...
Bizdēna, Ērika +2 more
core +1 more source
, 2018 An efficient route to construct chiral acyclic purine nucleoside analogues via dynamic kinetic resolution of α-purine substituted alkanoic acids is reported.
Mingsheng Xie (2031331) +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source