Results 131 to 140 of about 25,543 (277)

Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1-phosphate [PDF]

, 2011
A binary complex between a low-molecular-weight purine nucleoside phosphorylase and ribose-1-phosphate is described for the first time and comparisons with known ternary complexes are ...
D’Muniz Pereira, Humberto, Garratt, Richard Charles, Oliva, Glaucius   +2 more
core   +2 more sources

The clinical diagnostic value of a study of the activity of enzymes of the guanyl branch of purine metabolism in patients with ankylosing spondyloarthritis

Терапевтический архив, 2010
Aim. To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS. Materials and methods.
Aleksandr Borisovich Zborovskiy, Elena Eduardovna Mozgovaya, Vladislav Fedorovich Martem'yanov, Ol'ga Petrovna Slyusar', Mikhail Yur'evich Stazharov, S A Bedina, A B Zborovsky, E E Mozgovaya, V F Martemyanov, O P Slyusar, M Yu Stazharov, S A Bedina   +11 more
doaj  

Fused Heterocyclic Systems with an s-Triazine Ring. 34. Development of a Practical Approach for the Synthesis of 5-Aza-isoguanines

Molecules, 2019
Purine isosteres present excellent opportunities in drug design and development. Using isosteres of natural purines as scaffolds for the construction of new therapeutic agents has been a valid strategy of medicinal chemistry.
Ahmad Junaid, Felicia Phei Lin Lim, Yvonne Peijun Zhou, Wai Keung Chui, Anton V. Dolzhenko   +4 more
doaj   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

The Regulation of Brain Nucleoside Utilization [PDF]

, 2014
The homeostatic regulation of intracellular purine and pyrimidine pools has long been studied at the level of de novo nucleotide synthesis. However, brain maintains the proper qualitative and quantitative nucleotide balance by salvaging preformed ...
BALESTRI, FRANCESCO, IPATA, PIERO LUIGI
core   +1 more source

Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency [PDF]

, 1978
Amos Cohen, Lorraine J. Gudas, Arthur J. Ammann, G.E.J. Staal, David W. Martin   +4 more
openalex   +1 more source

Purine Nucleoside Phosphorylase from Escherichia coli and Salmonella typhimurium [PDF]

, 1975
Kaj Frank Jensen, Per Nygaard
openalex   +1 more source

Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

Pharmaceutical and Biomedical Research, 2019
Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi, Lira Barua, Debpriya Bhattacharjee, Gulamur Rahman, Syeda Sakiatuz Zannat, Najia Absar Munia, Rubaiyat Fahad, Tanjiba Harun Bipasha, Azizur Rahman, Raju Dash   +9 more
doaj  

Purine Nucleoside Phosphorylase Deficiency in Two Unrelated Patients with Autoimmune Hemolytic Anemia and Eosinophilia: Two Novel Mutations. [PDF]

Arch Iran Med, 2023
Alizadeh Z, Badalzadeh M, Heydarlou H, Shakerian L, Mahlooji Rad M, Zandieh F, Fazlollahi MR.   +6 more
europepmc   +1 more source

Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]

J Phys Chem B, 2023
Frost CF, Balasubramani SG, Antoniou D, Schwartz SD.   +3 more
europepmc   +1 more source