Results 131 to 140 of about 24,465 (266)

Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase [PDF]

The use of E. coli purine nucleoside phosphorylase (PNP) to activate prodrugs has demonstrated excellent activity in the treatment of various human tumor xenografts in mice. E. coli PNP cleaves purine nucleoside analogs to generate toxic adenine analogs,
BW Hughes, BW Hughes, C Altaner, CK Tai, DJ Dykes, DJ Giard, E J Sorscher, EJ Sorscher, EM Bennett, G Ungerechts, J S Hong, JA Montgomery, JS Hong, M Tiraby, MR Hersh, P Erbs, P W Allan, PE Noker, R Martiniello-Wilks, W B Parker, W R Waud, WB Parker, WB Parker, WB Parker, WB Parker, WB Parker, Y Adachi   +26 more
core   +2 more sources

Purine Nucleoside Phosphorylase from Escherichia coli and Salmonella typhimurium [PDF]

, 1975
Kaj Frank Jensen, Per Nygaard
openalex   +1 more source

Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

Pharmaceutical and Biomedical Research, 2019
Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi, Lira Barua, Debpriya Bhattacharjee, Gulamur Rahman, Syeda Sakiatuz Zannat, Najia Absar Munia, Rubaiyat Fahad, Tanjiba Harun Bipasha, Azizur Rahman, Raju Dash   +9 more
doaj  

Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: A tangible union against chemoresistant cancer

BMC Cancer, 2011
Background Late stage Ovarian Cancer is essentially incurable primarily due to late diagnosis and its inherent heterogeneity. Single agent treatments are inadequate and generally lead to severe side effects at therapeutic doses.
Joshi Swapna, Singh Preetinder P, Russell Pamela J, Nair Sham, Khatri Aparajita   +4 more
doaj   +1 more source

Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]

J Phys Chem B, 2023
Frost CF, Balasubramani SG, Antoniou D, Schwartz SD.   +3 more
europepmc   +1 more source

Control of ATP homeostasis during the respiro‐fermentative transition in yeast

Molecular Systems Biology, 2010
Respiring Saccharomyces cerevisiae cells respond to a sudden increase in glucose concentration by a pronounced drop of their adenine nucleotide content ([ATP]+[ADP]+[AMP]=[AXP]).
Thomas Walther, Maite Novo, Katrin Rössger, Fabien Létisse, Marie‐Odile Loret, Jean‐Charles Portais, Jean‐Marie François   +6 more
doaj   +1 more source

Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency [PDF]

, 1978
Amos Cohen, Lorraine J. Gudas, Arthur J. Ammann, G.E.J. Staal, David W. Martin   +4 more
openalex   +1 more source

Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction. [PDF]

Nat Rev Urol, 2022
Birder LA, Jackson EK.
europepmc   +1 more source

Upfront Enzyme Replacement via Erythrocyte Transfusions for PNP Deficiency [PDF]

, 2021
Albert, Michael H, Dedieu, Cinzia, Eichinger, Anna, Hauck, Fabian, la Marca, Giancarlo, Schroeder, Sebastian A, von Bernuth, Horst   +6 more
core   +2 more sources

RESIDUAL PURINE NUCLEOSIDE PHOSPHORYLASE ACTIVITY IN A NEW DUTCH PATIENT WITH PNP-DEFICIENCY AND CELLULAR IMMUNODEFICIENCY: 172 [PDF]

, 1985
Gert Rijksen, B.J.M. Zegers, L. J. M. Spaapen, W. Kuis, M. Durán, B S Voorbrood, G.E.J. Staal, S.K. Wadman   +7 more
openalex   +1 more source