Results 291 to 300 of about 1,297,457 (342)

Purine Metabolism and Immunodeficiency

Pediatrics International, 1981
Summary Effects of the abnormalities of purine metabolism on the lymphocytes were studied. When the lymphocytes from the patients with Lesch-Nyhan syndrome in which HGPRT is defective were analysed. Immunoglobulin production from B-cells, mitotic response of T-cells, functions of helper T-cells and suppressor T-cells were thought to be impared ...
Junichi Yata, Toshiro Nakagawa
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Disorders of Purine Metabolism

1991
Gout is a heterogeneous group of disorders of purine metabolism which leads to hyperuricemia and arthritis as well as gout nodules (tophi) from deposition of urate crystals in and around the joints and in the skin. The hyperuricemia in primary gout is related to overproduction or reduced renal excretion of uric acid, while in secondary gout it is due ...
Helmut H. Wolff, Gerd Plewig, Richard K. Winkelmann, Otto Braun-Falco   +3 more
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Purine Metabolism in Feline Lymphomas

Veterinary Pathology, 1990
Deficiency of the purine metabolic enzyme adenosine deaminase causes severe immunodeficiency. Retroviruses have been reported to decrease the activity of adenosine deaminase, and many retroviruses, including feline leukemia virus, cause immunodeficiency.
S. C. Johnson, K. S. Waddell, L. Mathes, E. A. Copelan   +3 more
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Human Purine Metabolism [PDF]

, 1988
The purpose of purine metabolism in man is to maintain an optimal level of the nucleotides in the tissues. The nucleotides play an important role in nearly all biochemical processes, including energy metabolism, DNA and RNA structure, and regulation of many metabolic pathways through allosteric effects on enzymes, or through the adenylate energy charge.
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Disorders of Purine and Pyrimidine Metabolism

2000
Inborn errors of purine and pyrimidine metabolism manifest themselves by a variety of clinical pictures. Table I gives a list of the major presenting signs and laboratory results that should lead to further investigations to rule out or to confirm the diagnostic possibilities listed.
Sandrine Marie, Marie-Françoise Vincent, Georges Van den Berghe   +2 more
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Dual‐Specificity Tyrosine Phosphorylation–Regulated Kinase 3 Loss Activates Purine Metabolism and Promotes Hepatocellular Carcinoma Progression

Hepatology, 2019
Cancer cells metabolize different energy sources to generate biomass rapidly. The purine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes.
Fei Ma, Yuekun Zhu, Xing Liu, Qingxin Zhou, Xuehui Hong, C. Qu, Xing Feng, Yiyun Zhang, Qingbin Ding, Jiabao Zhao, Jingjing Hou, Mengya Zhong, Huiqin Zhuo, Lifeng Zhong, Zhijian Ye, Wen Xie, Yu Liu, Yubo Xiong, Hongwei Chen, D. Piao, Bei Sun, Zhi Gao, Qinghua Li, Zhen Zhang, Xingfeng Qiu, Zhiyong Zhang   +25 more
semanticscholar   +1 more source

Purine and pyrimidine metabolism in the trypanosomatidae

Molecular and Biochemical Parasitology, 1984
The pathways leading to purine and pyrimidine nucleotide production in members of the family Trypanosomatidae are discussed with special emphasis on data relating to pathogenic species published from 1974 to 1983 inclusive. Trypanosomes and leishmania in general lack a de novo purine biosynthetic pathway, but have a multiplicity of possible routes for ...
David J. Hammond, Winston E. Gutteridge
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The purine metabolism of human erythrocytes

Biochemistry (Moscow), 2006
This review summarizes currently available information about a crucial part of erythrocyte metabolism, that is, purine nucleotide conversions and their relationships with other conversion pathways. We describe the cellular resynthesis, interconversion, and degradation of purine compounds, and also the regulatory mechanisms in the conversion pathways ...
E. Skotnicka, A. J. Hlynczak, Wioleta Dudzińska, M. Suska   +3 more
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Purine metabolism in Schistosoma mansoni

International Journal for Parasitology, 1972
Abstract Schistosoma mansoni has been found to have a spectrum of purine nucleotides which is similar, but not identical to mammalian cells. The principal component of this system is ATP, which is present at a level of about 5·5 × 10 −9 moles/mg worm pairs.
Alfred W. Senft, Deborah G. Senft, Ralph P. Miech, P.R. Brown   +3 more
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Metabolism of endogenous purines

1991
Much of our insight into the importance of specific enzymes governing sequential steps in purine metabolism has derived from the discovery of individuals with an inherited deficiency of one of these enzymes (see Chapter 11). This has been particularly important for understanding the mechanisms responsible for the regulation of purine biosynthesis and ...
T. W. Stone, H. A. Simmonds
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