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Purine metabolism in Trypanosoma cruzi
Molecular and Biochemical Parasitology, 1981Culture forms of Trypanosoma cruzi are incapable of synthesizing purines de novo from formate, glycine, or serine and require an exogenous purine for growth. Adenine, hypoxanthine, guanine, xanthine and their respective ribonucleosides are equal in their abilities to support growth.
Randolph L. Berens +3 more
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Archives of Internal Medicine, 1968
This book contains the proceedings of the conference on Gout and Purine Metabolism held in October 1964. Originally published as a supplement to Arthritis and Rheumatism , it is now being offered in hardback form. All of the recognized authorities have contributed, and a great deal of data has been collected in one place. It must be recognized, however,
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This book contains the proceedings of the conference on Gout and Purine Metabolism held in October 1964. Originally published as a supplement to Arthritis and Rheumatism , it is now being offered in hardback form. All of the recognized authorities have contributed, and a great deal of data has been collected in one place. It must be recognized, however,
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Enzymes of purine metabolism in cancer
Clinical Biochemistry, 1983In cancer cells, a marked imbalance in the enzymic pattern of purine metabolism is linked with transformation and/or progression. In chemically-induced, transplantable hepatomas in rat, the specific activities of the anabolic enzymes, IMP dehydrogenase, GMP synthetase, adenylosuccinate synthetase, adenylosuccinase, AMP deaminase and ...
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Disorders of Purine and Pyrimidine Metabolism [PDF]
, 1976 Substantial progress has been made in the past year in identifying new primary disorders associated with abnormalities of purine and pyrimidine metabolism, in defining more precisely the metabolic consequences of specific enzyme defects, and in deducing the mechanisms involved in producing their clinical expression.
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Disorders of purine and pyrimidine metabolism
Molecular Genetics and Metabolism, 2005The disorders of purine and pyrimidine metabolism are unusual in their variety of clinical presentations and in the mechanisms by which these presentations result from the fundamental mutations. In the most common of the hyperuricemic metabolic disorders, deficiency of hypoxanthine phosphoribosyl transferase, the fundamental deficiency in the activity ...
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Purine Metabolism in Rat Macrophages
1984The association of deficiencies of purine metabolic enzymes with immunodeficiency diseases has stimulated research in purine metabolism of lymphoid cells. Up to now our knowledge about purine metabolism of other cells of the immune system, e.g., macrophages, is relatively limited.
Amos Cohen, Jerzy Barankiewicz
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Antipurines and Purine Metabolism
1988The study of the involvement of purines in lymphocyte function has been highlighted by two dramatic and unrelated discoveries. The first, the discovery in 1958 that 6-mercaptopurine (6-MP) had marked immunosuppressive properties (Schwartz et al. 1958), was followed by the wide use of its S-substituted analog, azathioprine (Aza), to prevent rejection of
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Metabolism of Pyrimidines and Purines
1982As in bacterial and animal systems, the purine and pyrimidine nucleotides in plants as well as their derivatives are operative as constituents of nucleic acids and coenzymes as well as in regulatory acting Compounds. They are involved in the synthesis of thiamine, riboflavine, folic acid pteridines, histidine, or are constituents of cytokinins, purine ...
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Extracellular purine metabolism
Drug Development Research, 1996A variety of nucleotides and the nucleoside adenosine can act as extracellular signaling substances. Their function is terminated by extracellular degradation via surface-located enzymes. The breakdown products may be recycled. This review discusses recent developments in the cellular and molecular biology of enzymes involved in extracellular purine ...
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
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