Results 51 to 60 of about 6,269 (168)

A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase [PDF]

Journal of Medicinal Chemistry, 2008
The potent immucillin purine nucleoside phosphorylase (PNP ) inhibitors F-DADMe-ImmH [(3S,4S)-3], and [(3R,4R)-3] are synthesized in seven steps. Cycloaddition to a fluoroalkene and an enzymic resolution are the key features of the construction of the fluoropyrrolidines 11, from which the immucillins are assembled by use of a three-component Mannich ...
Jennifer M, Mason, Andrew S, Murkin, Lei, Li, Vern L, Schramm, Graeme J, Gainsford, Brian W, Skelton   +5 more
openaire   +2 more sources

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Rationale for the Use of 8‐Aminoguanine for the Management of Cystitis

International Journal of Urology, Volume 33, Issue S1, May 2026.
ABSTRACT Bladder pain and associated lower urinary tract symptoms (LUTSs) are hallmark features of interstitial cystitis/bladder pain syndrome (IC/BPS) and hemorrhagic cystitis (HC). IC/BPS is characterized by bladder‐based pain and irritative bladder symptoms, with or without gross inflammatory changes (Hunner lesions) in the bladder wall, and the ...
Lori A. Birder, Joel N. H. Stern, Robert Moldwin, Edwin K. Jackson   +3 more
wiley   +1 more source

Mycoplasma hyorhinis‐encoded cytidine deaminase efficiently inactivates cytosine‐based anticancer drugs

FEBS Open Bio, 2015
Mycoplasmas may colonize tumor tissue in patients. The cytostatic activity of gemcitabine was dramatically decreased inMycoplasma hyorhinis‐infected tumor cell cultures compared with non‐infected tumor cell cultures.
Johan Vande Voorde, Peter Vervaeke, Sandra Liekens, Jan Balzarini   +3 more
doaj   +1 more source

Purine nucleoside phosphorylase (PNP) deficiency: across-the-board severe combined immunodeficiency

Egyptian Journal of Medical Human Genetics
Background Purine nucleoside phosphorylase (PNP) deficiency is a rare, autosomal recessive, inborn error of immunity. It is characterized by progressive immune abnormalities ranging from severe combined immunodeficiency (SCID) to combined ...
Engy A. Chohayeb, Sohilla Lotfy, Rabab E. El Hawary, Safa S. Meshaal, Iman A. Mansour, Nermeen M. Galal, Aisha M. Elmarsafy   +6 more
doaj   +1 more source

Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau, Nicoletta Luxi, Fabio Riefolo, Martín Solorzano, Irene Pazos, Elena Ballarín, Lise Skovgaard Svingel, Lorenzo Chiusaroli, Elisa Martín‐Merino, Elisa Barbieri, María Lopez‐Lasanta, Sima Mohammadi, Denis Rotta, Alexandra Pacurariu, Catherine Cohet, Miriam Sturkenboom, Carlos E. Durán, on behalf of the SAFETY‐VAC study consortium, Carlos E. Durán, Miriam Sturkenboom, Judit Riera‐Arnau, Nicoletta Luxi, Olaf Klungel, Patrick Souverein, Sima Mohammadi, Fabio Riefolo, Irene Pazos, Rosa Gini, Davide Messina, Giuseppe Roberto, Carlo Giaquinto, Elisa Barbieri, Luca Stona, Felipe Villalobos, Martín Solorzano, Carlo Alberto Bissacco, Antonio Gimeno, Beatriz Poblador, Mercedes Aza, Aida Moreno, Alejandro Santos, Vera Ehrenstein, Lise Skovgaard Svingel, Benjamin Randeris Johannesen, Cécile Droz‐Perroteau, Laure Carcaillon‐Bentata, Anna‐Mija Tolppanen, Sirpa Hartikainen, Thuan Vo, Anne Paakinaho, Blair Rajamaki, Hedvig Nordeng, Saeed Hayati, Mahmoud Zidan, Juan José Carreras Martínez, Arantxa Urchueguía Fornes, Elisa Correcher Martínez, Javier Díez‐Domingo, Mar Martin, Patricia Garcia‐Poza, Airam de Burgos, Belén Castillo‐Cano, Elisa Martín‐Merino   +62 more
wiley   +1 more source

A Simple Method for RNA‐Seq of Manually Isolated Chromatophores in Oryzias Fishes

Development, Growth &Differentiation, Volume 68, Issue 3, April 2026.
ABSTRACT RNA sequencing (RNA‐seq) has become an essential tool for analyzing gene expression and exploring cell type–specific transcriptomes. However, sample preparation and quality control remain challenging, as current approaches typically rely on dissecting tissues containing mixed cell populations or using flow cytometry to isolate fluorescently ...
Makoto Goda, Asuka Miyagi, Keisuke Sugiwaka, Masakatsu Watanabe, Manabu Bessho‐Uehara, Masahiko Hibi, Atsushi Toyoda, Rieko Tanaka, Kawilarang W. A. Masengi, Kazunori Yamahira, Satoshi Ansai, Hisashi Hashimoto   +11 more
wiley   +1 more source

The cytokinesis regulator RacGAP1 is a Rac1‐specific GAP on membranes

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Rho family small GTPases are essential for cytokinesis completion. RacGAP1, a dimeric multidomain protein with a lipid‐binding C1 domain and a GTPase‐activating protein (GAP) domain, is a major regulator in this process. However, despite many cellular and biochemical studies, whether RhoA or Rac1 is the actual substrate inactivated by RacGAP1 ...
Pavlina Dubois, Yann Ferrandez, Clara Rey, Cyril Pages, Agata Nawrotek, Jacqueline Cherfils   +5 more
wiley   +1 more source

Circulating Human Neonatal Naïve B cells are Deficient in CD73 Impairing Purine Salvage

Frontiers in Immunology, 2016
Background: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate (ATP), are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood may influence their function
Matthew Aaron Pettengill, Ofer eLevy, Ofer eLevy   +2 more
doaj   +1 more source

A specific adenosine phosphorylase, distinct from purine nucleoside phosphorylase

FEBS Letters, 1976
Several enzymes, catalyzing the reversible phosphorolysis of purine nucleosides have been described in eucaryotic cells and in micro-organisms [l-6] . The best known is the ‘purine nucleoside phosphorylase’ (EC 2.4.2.1) acting on the nucleosides of hypoxanthine and guanine. Adenosine is not used as substrate by this enzyme [6-81.
SENESI, SONIA, FALCONE, GIUSEPPE, MURA, UMBERTO, SGARRELLA F, IPATA, PIERO LUIGI   +4 more
openaire   +5 more sources