Results 71 to 80 of about 6,269 (168)

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase

Pharmaceutical and Biomedical Research, 2019
Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi, Lira Barua, Debpriya Bhattacharjee, Gulamur Rahman, Syeda Sakiatuz Zannat, Najia Absar Munia, Rubaiyat Fahad, Tanjiba Harun Bipasha, Azizur Rahman, Raju Dash   +9 more
doaj  

Purine Nucleoside Phosphorylase Deficiency in Two Unrelated Patients with Autoimmune Hemolytic Anemia and Eosinophilia: Two Novel Mutations. [PDF]

Arch Iran Med, 2023
Alizadeh Z, Badalzadeh M, Heydarlou H, Shakerian L, Mahlooji Rad M, Zandieh F, Fazlollahi MR.   +6 more
europepmc   +1 more source

The structure of His-tagged Geobacillus stearothermophilus purine nucleoside phosphorylase reveals a `spanner in the works'. [PDF]

Acta Crystallogr F Struct Biol Commun, 2022
Given FM, Moran F, Johns AS, Titterington JA, Allison TM, Crittenden DL, Johnston JM.   +6 more
europepmc   +1 more source

Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]

J Phys Chem B, 2023
Frost CF, Balasubramani SG, Antoniou D, Schwartz SD.   +3 more
europepmc   +1 more source

Uncovering metabolic reprogramming in ovarian and cervical cancers with multi-omics

iScience
Summary: Ovarian cancer (OC) and cervical cancer (CC) are major causes of gynecological malignancy mortality, but their spatially resolved metabolic features and shared progression-driving metabolic reprogramming remain unexplored.
Yunxiao Ge, Yanlin Luo, Bingbing Hao, Yubing Zhou, Rui Wu, Hangrui Liu, Lin Tang, Yuanying Li, Yushu Li, Shuting Gong, Hui Liu   +10 more
doaj   +1 more source

Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells. [PDF]

J Biol Chem, 2022
Kropotov A, Kulikova V, Solovjeva L, Yakimov A, Nerinovski K, Svetlova M, Sudnitsyna J, Plusnina A, Antipova M, Khodorkovskiy M, Migaud ME, Gambaryan S, Ziegler M, Nikiforov A.   +13 more
europepmc   +1 more source

Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction. [PDF]

Nat Rev Urol, 2022
Birder LA, Jackson EK.
europepmc   +1 more source

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. [PDF]

J Med Chem, 2023
Skácel J, Djukic S, Baszczyňski O, Kalčic F, Bílek T, Chalupský K, Kozák J, Dvořáková A, Tloušt'ová E, Král'ová Z, Šmídková M, Voldřich J, Rumlová M, Pachl P, Brynda J, Vučková T, Fábry M, Snášel J, Pichová I, Řezáčová P, Mertlíková-Kaiserová H, Janeba Z.   +21 more
europepmc   +1 more source

Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation

Gut Microbes
Gut microbiota dysbiosis has been implicated in the pathogenesis of irritable bowel syndrome (IBS), a globally prevalent functional gastrointestinal disorder; however, mechanistic insights remain limited.
Songyuan Hou, Tingting Ning, Si Liu, Xinyi Yang, Haozhen Ye, Yesheng Zhou, Chenxu Wang, Jiaqi Zhu, Shaochong Lu, Nan Zhang, Shengtao Zhu   +10 more
doaj   +1 more source