Results 81 to 90 of about 27,209 (247)
Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi +8 more
wiley +1 more source
Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase
Eukaryotic Cell, 2014 The intracellular pathogen Toxoplasma gondii is a purine auxotroph that relies on purine salvage for proliferation. We have optimized T. gondii purine nucleoside phosphorylase (TgPNP) stability and crystallized TgPNP with phosphate and immucillin-H, a ...
T. Donaldson +9 more
semanticscholar +1 more source
Journal of Clinical Laboratory Analysis, Volume 40, Issue 2, January 2026.We evaluated a colorimetric assay using clinical reagents for determining Ca, IP, and Zn in human milk. Significant correlations were observed between Ca, IP, and Zn levels determined by colorimetric assay and Ca, total P, and Zn levels determined by ICP‐AES.
Miori Tanaka +3 more
wiley +1 more source
Nucleoside-dependent synthesis of organic phosphorus compounds by rat liver nuclei [PDF]
, 1967 a) A modified procedure of the WIDNELL and TATA8 method yields rat liver nuclei manifesting a high degree of purity and activity. b) These nuclei contain a nucleoside-dependent phosphorylating activity that is readily released and apparently unrelated to
Utsumi, Kozo
core +1 more source
Journal of Biomedical Sciences, 2014 BackgroundEnzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion proteins targeted via annexin V to ...
Katrin P. Guillen +2 more
semanticscholar +1 more source
Characterization and Antibody Preparation of the Gene Products of Grouper Iridovirus ORF5L
Aquaculture, Fish and Fisheries, Volume 5, Issue 6, December 2025.ABSTRACT Grouper iridovirus (GIV) is a large DNA virus belonging to the family Iridoviridae and genus Ranavirus. It consists of 139,793 base pairs (bp) and 120 open reading frames (ORFs). GIV is a key pathogen of farmed fish worldwide. The functional roles of viral genes must be determined for the early diagnosis, treatment and prevention of viral ...
Chu‐Fan Cheng +2 more
wiley +1 more source
Distributed Kernel K-Means for Large Scale Clustering
, 2017 Clustering samples according to an effective metric and/or vector space representation is a challenging unsupervised learning task with a wide spectrum of applications.
Decherchi, Sergio +2 more
core +1 more source
Drug Testing and Analysis, Volume 17, Issue 12, Page 2323-2332, December 2025.Using targeted HILIC‐MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promise for inclusion in the Athlete Biological Passport (ABP), warranting further investigation to enhance anti‐doping detection strategies. ABSTRACT Increasing
Olivier Salamin +5 more
wiley +1 more source
FEBS Open Bio, 2015 Mycoplasmas may colonize tumor tissue in patients. The cytostatic activity of gemcitabine was dramatically decreased inMycoplasma hyorhinis‐infected tumor cell cultures compared with non‐infected tumor cell cultures.
Johan Vande Voorde +3 more
doaj +1 more source
Food Bioengineering, Volume 4, Issue 4, Page 546-563, December 2025.Screening and modification of probiotics that can efficiently reduce uric acid provide a new strategy for food‐grade hyperuricemia intervention. ABSTRACT Hyperuricemia has become one of the most prevalent global epidemics, significantly impacting both the economy and the health of individuals.
Le Wang +7 more
wiley +1 more source