Results 91 to 100 of about 27,209 (247)

A specific adenosine phosphorylase, distinct from purine nucleoside phosphorylase

FEBS Letters, 1976
Several enzymes, catalyzing the reversible phosphorolysis of purine nucleosides have been described in eucaryotic cells and in micro-organisms [l-6] . The best known is the ‘purine nucleoside phosphorylase’ (EC 2.4.2.1) acting on the nucleosides of hypoxanthine and guanine. Adenosine is not used as substrate by this enzyme [6-81.
SENESI, SONIA, FALCONE, GIUSEPPE, MURA, UMBERTO, SGARRELLA F, IPATA, PIERO LUIGI   +4 more
openaire   +5 more sources

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Purine nucleoside phosphorylase (PNP) deficiency: across-the-board severe combined immunodeficiency

Egyptian Journal of Medical Human Genetics
Background Purine nucleoside phosphorylase (PNP) deficiency is a rare, autosomal recessive, inborn error of immunity. It is characterized by progressive immune abnormalities ranging from severe combined immunodeficiency (SCID) to combined ...
Engy A. Chohayeb, Sohilla Lotfy, Rabab E. El Hawary, Safa S. Meshaal, Iman A. Mansour, Nermeen M. Galal, Aisha M. Elmarsafy   +6 more
doaj   +1 more source

In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer

, 2017
Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer.
Agirre, Xabier, Apaolaza, Iñigo, Atauri, Pedro de, Carracedo, Arkaitz, Cascante i Serratosa, Marta, Cendoya, Xabier, Garate, Leire, Miranda, Estíbaliz, Ochoa, María Carmen, Pey, Jon, Planes, Francisco J., Prosper, Felipe, Rubio, Angel, San José-Eneriz, Edurne   +13 more
core   +3 more sources

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient–Gene–Disease Interaction

Immunity, Inflammation and Disease, Volume 13, Issue 12, December 2025.
Our findings indicate that Cordyceps Sinensis (CS) alleviates COPD symptoms by inhibiting inflammation and oxidative stress, with key biomarkers such as interleukins (ILs), tumor necrosis factor (TNF), and reactive oxygen species (ROS) identified. Activating autophagy serves as a protective mechanism against COPD development induced by oxidative stress.
Zirui Zang, Yuhan Kong, Qi Kong
wiley   +1 more source

A UV/Vis Spectroscopy-Based Assay for Monitoring of Transformations Between Nucleosides and Nucleobases [PDF]

, 2019
Efficient reaction monitoring is crucial for data acquisition in kinetic and mechanistic studies. However, for conversions of nucleosides to their corresponding nucleobases, as observed in enzymatically catalyzed nucleoside phosphorylation reactions, the
Giessmann, Robert T., Gimpel, Matthias, Kaspar, Felix, Krausch, Niels, Neubauer, Peter, Wagner, Anke   +5 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Methylthioadenosine [PDF]

, 2004
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. MTA is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory ...
Avila, M.A. (Matías Antonio), Corrales, F.J. (Fernando José), Lu, S.C. (Shelly C.), Mato, J.M. (José María), Ruiz Garcia-Trevijano, E. (Elena)   +4 more
core   +1 more source

Circulating Human Neonatal Naïve B cells are Deficient in CD73 Impairing Purine Salvage

Frontiers in Immunology, 2016
Background: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate (ATP), are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood may influence their function
Matthew Aaron Pettengill, Ofer eLevy, Ofer eLevy   +2 more
doaj   +1 more source

Transcriptomic and enzymological evidence for plastid peptidoglycan synthesis in the gymnosperm Picea abies

The Plant Journal, Volume 124, Issue 5, December 2025.
Significance Statement Peptidoglycan (murein) biosynthesis is involved in chloroplast division in mosses, while Arabidopsis MurE mutants are defective in chloroplast development. We have shown that the gymnosperm Picea abies expresses 11 genes of the peptidoglycan biosynthesis pathway, and that P.
Yayoi Sugita, Amanda J. Dowson, Ichiro Kajisa, Katsuaki Takechi, Yilan E, Jingzhi Zhao, Jiaqi Wang, Xiaofei Lin, Laura Diaz‐Saez, Adrian J. Lloyd, Christopher G. Dowson, Hiroyoshi Takano   +11 more
wiley   +1 more source