Results 111 to 120 of about 6,269 (168)
Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels. [PDF]
Proc Natl Acad Sci U S A, 2018 Harijan RK +4 more
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Use of E. coli Purine Nucleoside Phosphorylase in the Treatment of Solid Tumors. [PDF]
Curr Pharm Des, 2017 Parker WB, Sorscher EJ.
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Study on purine metabolismn Purine nucleoside phosphorylase
Uric acid research, 1977 Ito, Kazuhiko +3 more
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Histochemical demonstration of purine nucleoside phosphorylase activity.
The Bulletin of Tokyo Medical and Dental University, 1969 openaire +2 more sources
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Symmetric Nucleosides as Potent Purine Nucleoside Phosphorylase Inhibitors
The Journal of Physical Chemistry B, 2021Nucleic acids are one of the most enigmatic biomolecules crucial to several biological processes. Nucleic acid-protein interactions are vital for the coordinated and controlled functioning of a cell, leading to the design of several nucleoside/nucleotide analogues capable of mimicking these interactions and hold paramount importance in the field of ...
Pradeep Pant, Amita Pathak, B. Jayaram
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Purine nucleoside phosphorylase of chicken liver
Biochimica et Biophysica Acta (BBA) - Enzymology, 1971Abstract Purine nucleoside phosphorylase (purine nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) has been purified 125-fold from the homogenate of chicken livers and some of the properties of the purified enzyme have been studied. This enzyme had a pH optimum at around 6.o. At high substrate levels of inosine the reaction rate was increased,
K, Murakami, A, Mitsui, K, Tsushima
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Characterization of purine nucleoside phosphorylase in leukemia
American Journal of Hematology, 1986AbstractPurine nucleoside phosphorylase (PNP) activity was determined in mononuclear cells from 49 patients with various types of leukemia. A low level of PNP activity was found in mononuclear cells from patients with acute myeloid and lymphoblastic leukemia and with chronic lymphocytic leukemia. Enzymatic and immunological studies on PNP from leukemic
T, Morisaki +3 more
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Adenine as Substrate for Purine Nucleoside Phosphorylase
Canadian Journal of Biochemistry, 1971Purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) from four sources (rat liver and brain, human erythrocytes, and calf spleen) has been shown to exhibit a low intrinsic activity towards adenine in the presence of ribose 1-phosphate.
T P, Zimmerman +3 more
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Allosteric regulation of purine nucleoside phosphorylase
Archives of Biochemistry and Biophysics, 1991Purine nucleoside phosphorylase (EC 2.4.2.1) from bovine spleen is allosterically regulated. With the substrate inosine the enzyme displayed complex kinetics: positive cooperativity vs inosine when this substrate was close to physiological concentrations, negative cooperativity at inosine concentrations greater than 60 microM, and substrate inhibition ...
P A, Ropp, T W, Traut
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Mutations in purine nucleoside phosphorylase deficiency
Human Mutation, 1997Purine nucleoside phosphorylase deficiency is an inherited disease of purine metabolism characterized clinically as combined immunodeficiency. The molecular defects have been published for 4 different alleles in 3 patients. We report four new mutations including two amino acid substitutions, A174P and G190V, a single codon deletion, delta I129, and a ...
M L, Markert +8 more
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