Results 131 to 140 of about 27,209 (247)

Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. [PDF]

, 2018
The Hsp90 molecular chaperones are ATP-dependent enzymes that maintain protein homeostasis and regulate many essential cellular processes. Higher eukaryotes have organelle-specific Hsp90 paralogs that are adapted to each subcellular environment.
Agard, David A, Elnatan, Daniel
core  

Metabolic constraint of human telomere length by nucleotide salvage efficiency

Nature Communications
Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz, Andrew Crompton, Noah Lampl, Suneet Agarwal   +3 more
doaj   +1 more source

Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium. [PDF]

J Enzyme Inhib Med Chem, 2022
Narczyk M, Wojtyś MI, Leščić Ašler I, Žinić B, Luić M, Jagusztyn-Krynicka EK, Štefanić Z, Bzowska A.   +7 more
europepmc   +1 more source

8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity. [PDF]

J Pharmacol Exp Ther, 2022
Jackson EK, Menshikova EV, Ritov VB, Mi Z, Birder LA.   +4 more
europepmc   +1 more source

Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons. [PDF]

Sci Rep, 2022
Tsui M, Biro J, Chan J, Min W, Dobbs K, Notarangelo LD, Grunebaum E.   +6 more
europepmc   +1 more source

A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori. [PDF]

Appl Microbiol Biotechnol, 2021
Wojtyś MI, Jaźwiec R, Kazazić S, Leščić Ašler I, Knežević P, Aleksić Sabo V, Luić M, Jagusztyn-Krynicka EK, Bzowska A.   +8 more
europepmc   +1 more source

Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase

Proceedings of the National Academy of Sciences of the United States of America, 2017
R. Harijan, I. Zoi, D. Antoniou, S. Schwartz, V. Schramm   +4 more
semanticscholar   +1 more source

Evidence for purine nucleoside phosphorylase (PNP) release from rat C6 glioma cells

Journal of Neurochemistry, 2017
P. Giuliani, M. Zuccarini, S. Buccella, Luis Emiliano Peña-Altamira, E. Polazzi, M. Virgili, Barbara Monti, A. Poli, M. Rathbone, P. Di Iorio, R. Ciccarelli, F. Caciagli   +11 more
semanticscholar   +1 more source

A resistant mutant of Plasmodium falciparum purine nucleoside phosphorylase uses wild-type neighbors to maintain parasite survival. [PDF]

J Biol Chem, 2021
Minnow YVT, Harijan RK, Schramm VL.
europepmc   +1 more source

Partial Purine Nucleoside Phosphorylase Deficiency: an Unexpected Diagnosis in an Adult Patient. [PDF]

J Clin Immunol
Ahuja M, Fairbanks L, Stroud C, Schaefer A, Elcombe SE.   +4 more
europepmc   +1 more source