Results 121 to 130 of about 27,209 (247)

Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]

J Phys Chem B, 2023
Frost CF, Balasubramani SG, Antoniou D, Schwartz SD.   +3 more
europepmc   +1 more source

Uncovering metabolic reprogramming in ovarian and cervical cancers with multi-omics

iScience
Summary: Ovarian cancer (OC) and cervical cancer (CC) are major causes of gynecological malignancy mortality, but their spatially resolved metabolic features and shared progression-driving metabolic reprogramming remain unexplored.
Yunxiao Ge, Yanlin Luo, Bingbing Hao, Yubing Zhou, Rui Wu, Hangrui Liu, Lin Tang, Yuanying Li, Yushu Li, Shuting Gong, Hui Liu   +10 more
doaj   +1 more source

Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction. [PDF]

Nat Rev Urol, 2022
Birder LA, Jackson EK.
europepmc   +1 more source

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors. [PDF]

J Med Chem, 2023
Skácel J, Djukic S, Baszczyňski O, Kalčic F, Bílek T, Chalupský K, Kozák J, Dvořáková A, Tloušt'ová E, Král'ová Z, Šmídková M, Voldřich J, Rumlová M, Pachl P, Brynda J, Vučková T, Fábry M, Snášel J, Pichová I, Řezáčová P, Mertlíková-Kaiserová H, Janeba Z.   +21 more
europepmc   +1 more source

Purine Nucleoside Phosphorylase Deficiency [PDF]

Journal of Clinical Investigation, 1977
William R. A. Osborne, Shi-Han Chen, Eloise R. Giblett, W. Douglas Biggar, Arthur A. Ammann, C. Ronald Scott   +5 more
openaire   +1 more source

Analysis of Multiple Isoenzyme Expression Among Twenty-Two Species of Mycoplasma and Acholeplasma [PDF]

, 1981
Crude extracts of triple-cloned, purified cultures of 22 species of Mycoplasma and Acholeplasma were examined for expression of 21 isozyme systems routinely used to type mammalian cells. Nine previously described enzymes (purine nucleoside phosphorylase,
Barile, Michael F., Grabowski, Marion W., O\u27Brien, Stephen J., Simonson, Janice M.   +3 more
core   +1 more source

Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation

Gut Microbes
Gut microbiota dysbiosis has been implicated in the pathogenesis of irritable bowel syndrome (IBS), a globally prevalent functional gastrointestinal disorder; however, mechanistic insights remain limited.
Songyuan Hou, Tingting Ning, Si Liu, Xinyi Yang, Haozhen Ye, Yesheng Zhou, Chenxu Wang, Jiaqi Zhu, Shaochong Lu, Nan Zhang, Shengtao Zhu   +10 more
doaj   +1 more source

Correction: The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans. [PDF]

PLoS Pathog, 2022
Tecle E, Chhan CB, Franklin L, Underwood RS, Hanna-Rose W, Troemel ER.   +5 more
europepmc   +1 more source

Trimeric Architecture Ensures the Stability and Biological Activity of the Calf Purine Nucleoside Phosphorylase: In Silico and In Vitro Studies of Monomeric and Trimeric Forms of the Enzyme. [PDF]

Int J Mol Sci, 2023
Dyzma A, Wielgus-Kutrowska B, Girstun A, Matošević ZJ, Staroń K, Bertoša B, Trylska J, Bzowska A.   +7 more
europepmc   +1 more source

Immunization with purine salvation pathway recombinant enzymes induces the production of anti- Schistosoma mansoni immunoglobulines [PDF]

Schistosomiasis, a disease caused by the trematodes of the Schistosoma genus, affects about 240 million people worldwide. The Praziquantel (PZQ) is the drug used to treat this disease. However, reports of resistant strains reinforce the need to develop a
Adachi, Felipe de Pontes, Anibal, Fernanda de Freitas, Correia, Ricardo de Oliveira, Dejani, Naiara Naiana, Garratt, Richard Charles, Neris, Débora Meira, Oliveira, Sandra Regina Pereira de, Pereira, Humberto D'Muniz, Rodolpho, Joice Margareth de Almeida, Rodrigues, Vanderlei, Souza, Laís Cristina de   +10 more
core