Results 71 to 80 of about 616,391 (245)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Sowing quality of seeds of the most common horse-chestnut species in the Western region of Ukraine

Наукові праці Лісівничої академії наук України, 2018
In the Western region of Ukraine, four kinds of horse-chestnuts are common in amenity stands of different species and types: common horse-chestnut (Aesculus hippocastanum L.), red buckeye (Aesculus pavia L.), yellow buckeye (Aesculus octañra Marsh.), and
Mykola Guz, Volodymyr Geval
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structured Emission and Entanglement Dynamics of a Giant Atom in a Photonic Creutz Ladder

Photonics
We explore the spontaneous emission dynamics of a giant atom coupled to a photonic Creutz ladder, focusing on how flat-band frustration and synthetic gauge fields shape atom–photon interactions.
Vassilios Yannopapas
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Identification Sugarcane Clones for Tolerance to Juice Quality Deterioration under Delayed Harvest and Different Time Intervals of Staling

International Journal of Bio-Resource and Stress Management
A study was under taken during January, 2022–March, 2023 at the Agricultural Research Station, Perumallapalle, Chittoor district, Andhra Pradesh, India to evaluate fifteen sugarcane clones including early and mid-late to identify clones with higher ...
N. V. Naidu, M. Sridhar, N. Sabitha, Vajantha B., Hemalatha T. M., M. S. Balaji, Tagore K. R.   +6 more
doaj   +1 more source

The Haptic and the Phatic in the Era of Globalization

Glocalism: Journal of Culture, Politics and Innovation, 2022
Touch is a universal faculty which lets humans explore intimacy, danger and other aspects of their sensory worlds. In India, the regulation of touch is the key to the maintenance of a highly hierarchical, unjust and humiliating social system. Today, the
Arjun Appadurai
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source