Results 71 to 80 of about 1,131,346 (296)

A Proposal for Afro-Hispanic Peoples and Culture as General Studies Course in African Universities

Humanities, 2019
After centuries of denial, suppression and marginalization, the contributions of Afro-Hispanics/Latinos to the arts, culture, and the Spanish spoken in the Americas is gradually gaining recognition as Afro-descendants pursue their quest for visibility ...
Purity Ada Uchechukwu
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Organic fraction of municipal solid waste for the production of L-lactic acid with high optical purity

Journal of Cleaner Production, 2020
The organic fraction of municipal solid waste (OFMSW) is an abundant biowaste with great potential in the bioeconomy model. Previous reports have demonstrated that OFMSW hydrolysates are good substrates for lactic acid (LA) production.
J. P. López-Gómez, M. Alexandri, R. Schneider, M. Latorre-Sánchez, Caterina Coll Lozano, J. Venus   +5 more
semanticscholar   +1 more source

Purity for flat cohomology [PDF]

Annals of Mathematics, 2019
We establish the flat cohomology version of the Gabber-Thomason purity for etale cohomology: for a complete intersection Noetherian local ring $(R, \mathfrak{m})$ and a commutative, finite, flat $R$-group $G$, the flat cohomology $H^i_{\mathfrak{m}}(R, G)
Kęstutis Česnavičius, P. Scholze
semanticscholar   +1 more source

Stability against crystallization and optical properties of (Ga10Ge15Te75)100-x(AgI)x ( x = 0–15 mol %) glasses

Конденсированные среды и межфазные границы
Objectives: Germanium telluride based glasses, due to theirwide transparency range and high refractive index, are promising optical materials for the middle infrared range.
Elizaveta A. Tyurina, Aleksandr P. Velmuzhov, Maxim V. Sukhanov, Aleksandr D. Plekhovich, Diana G. Fukina, Vladimir S. Shiryaev   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity

Journal for ImmunoTherapy of Cancer, 2020
Background Tumor mutational burden (TMB) measurement is limited by low tumor purity of samples, which can influence prediction of the immunotherapy response, particularly when using whole-exome sequencing-based TMB (wTMB). This issue could be overcome by
Tae Hee Hong, H. Cha, J. Shim, Boram Lee, Jongsuk Chung, Chung Lee, Nayoung K. D. Kim, Yoon-La Choi, Soohyun Hwang, Yoomi Lee, Sehhoon Park, H. Jung, Ji-Yeon Kim, Yeon Hee Park, Jong-Mu Sun, J. Ahn, Myung-Ju Ahn, Keunchil Park, Se-Hoon Lee, W. Park   +19 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source