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Axonal abnormalities in cerebellar Purkinje cells of the ?hyperspiny Purkinje cell? mutant mouse

Journal of Neurocytology, 1990
The hyperspiny Purkinje cell (hpc) is a murine, autosomal recessive mutation affecting cerebellar Purkinje cells. Axonal abnormalities in these neurons have been revealed by selective silver impregnation, specific immunohistochemical staining and electron microscopy.
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Cell Counts of Purkinje and Inferior Olivary Neurons in the ‘Hyperspiny Purkinje Cells’ Mutant Mouse

European Journal of Neuroscience, 1992
AbstractThe mutant mouse ‘hyperspiny Purkinje cells’(hpc) has morphologically abnormal Purkinje cells and below normal intracerebellar calbindin‐D28k, a calcium‐binding protein that, in the cerebellum, is found only in the Purkinje cells. We counted the Purkinje cells on serial sections stained with thionin or labelled with anti‐calbindin‐D28k ...
F., Frederic   +5 more
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Purkinje cell activation by stimulation of the labyrinth

Pfl�gers Archiv European Journal of Physiology, 1970
Caloric and galvanic stimulation of the labyrinth can modulate the activity of the Purkinje cells of the cerebellum through both mossy fibre and climbing fibre systems. The former system is modulated in a higher frequency range than the latter. These results were obtained mainly in the vestibular area, but they were also present in other areas of the ...
M, Ferin, R A, Grigorian, P, Strata
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The Purkinje Cell

2000
Abstract Jan Evangelista Purkinje (Purkyne) was born in 1787, in the castle of Libochovice, Bohemia, where his father acted as the estate manager. He received his first formal education at the Gymnasium connected to the monastery of the Fratres piarum scholarum, in Mikulov, South Moravia, and later joined this order. After completing his
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Heterotopic Purkinje cells in ataxia‐telangiectasia

Neuropathology, 2011
Ataxia‐telangiectasia (A‐T) is a heritable disorder of cerebellar ataxia and oculocutaneous telangiectasias caused by mutation of the ATM gene. The most prominent and consistent neuropathologic finding in the disorder is cerebellar cortical degeneration involving significant loss of granule and Purkinje cells.
Alexander R, Bottini   +3 more
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A Purkinje cell whodunit

Neuroscience Gateway, 2006
Compromised glutamate transport in Bergmann glia contributes to Purkinje cell death in a model of spinal cerebellar ataxia.
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Selective sensitivity of the Purkinje cells of the cerebellum

The American Journal of Medicine, 1954
Abstract A non-progressive parenchymatous cerebellar syndrome following abruptly upon an episode of hyperpyrexia is described. The relevant literature is reviewed and the syndrome is differentiated from progressive parenchymatous cerebellar degeneration.
D A, FREEDMAN, J C, ROURKE
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Design for Purkinje Cells

1992
We present a mathematical/computer model of a Purkinje cell. The model is a binary dendritic tree of Rall compartments connected to trunk, soma and then Hodgkin-Huxley axon. We perform studies of the model for different parameters, especially those provided by Shelton, and Pellionisz and Linas.
E. K. Blum, Xin Wang
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Purkinje Cells and their Responses

1967
In Chapter I there is an extensive account of the structural features of the most remarkable elements of the cerebellar cortex, the Purkinje cells, and in Chapter III there is a full description of the synapses that parallel fibers make with the spiny branchlets of Purkinje cell dendrites.
John C. Eccles   +2 more
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Gravity responses of Purkinje cells in the nodulus

Experimental Brain Research, 1976
In cats, either decerebrated or under chloralose anaesthesia, Purkinje cells (P-cells) of the cerebellar nodulus have been examined with the animal under static lateral tilt (roll +/- 20 degrees). The cell activity was extracellularly recorded and both "simple" and "complex" spike discharge patterns were studied. In 20 cells out of a population of 198,
G, Marini, L, Provini, A, Rosina
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