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Enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction
Ibrahim MF +8 more
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The Anatomical Record, 1969
AbstractIn the course of ultrastructural studies on the cerebellar cortex of young rats a cilium was found in some Purkinje cells. The shaft, which is 1800 to 2000 ÅR thick, has an internal portion inside the cell body and an external one projecting into the neuropile. The basal body is consistently located near the Golgi apparatus.
Manuel P. Del Cerro +2 more
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AbstractIn the course of ultrastructural studies on the cerebellar cortex of young rats a cilium was found in some Purkinje cells. The shaft, which is 1800 to 2000 ÅR thick, has an internal portion inside the cell body and an external one projecting into the neuropile. The basal body is consistently located near the Golgi apparatus.
Manuel P. Del Cerro +2 more
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Heart Rhythm, 2010
Purkinje cells are specialized for rapid propagation in the heart. Furthermore, Purkinje fibers as the source as well as the perpetuator of arrhythmias is a familiar finding. This is not surprising considering their location in the heart and their unique cell ultrastructure, cell electrophysiology, and mode of excitation-contraction coupling.
Penelope A, Boyden +2 more
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Purkinje cells are specialized for rapid propagation in the heart. Furthermore, Purkinje fibers as the source as well as the perpetuator of arrhythmias is a familiar finding. This is not surprising considering their location in the heart and their unique cell ultrastructure, cell electrophysiology, and mode of excitation-contraction coupling.
Penelope A, Boyden +2 more
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Cardiac Purkinje cells in culture
Journal of Molecular and Cellular Cardiology, 1983Purkinje cells from false tendons of young rabbits, pigs and fetal lambs were dispersed by the action of collagenase and elastase and grown in culture for up to 14 days. Immunofluorescent staining with fluorescein-labelled antibodies to cardiac myosin and tropomyosin demonstrated cross-banding and/or a diffuse positive stain in Purkinje cells between 3
Canale, E, Campbell, JH, Campbell, GR
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Motilin in the Purkinje cell of the cerebellum
Nature, 1982None of the brain peptides has been demonstrated to be present in significant amounts in the cerebellum1,2. The only effector substance known in the Purkinje cell, whose axon carries the integrated output of the cerebellar cortex, is the decarboxylated residue of glutamic acid3–6.
G, Nilaver +4 more
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Aging of cerebellar Purkinje cells
Cell and Tissue Research, 2010Cerebellar Purkinje cells (PCs), the sole output neurons in the cerebellar cortex, play an important role in the cerebellar circuit. PCs appear to be rather sensitive to aging, exhibiting significant changes in both morphology and function during senescence.
Changzheng, Zhang +2 more
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Excitatory synaptic currents in Purkinje cells
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1990The N-methyl-D-aspartate (NMDA) and non-NMDA classes of glutamate receptor combine in many regions of the central nervous system to form a dual-component excitatory postsynaptic current. Non-NMDA receptors mediate synaptic transmission at the resting potential, whereas NMDA receptors contribute during periods of postsynaptic depolarization and play a ...
Perkel, DJ +3 more
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1974
The apparent simplicity of the cerebellar cortex reflects in part the small number of neuronal types comprised in it. Most descriptions credit it with only five types of nerve cells: Purkinje cells, granule cells, basket cells, stellate cells, and Golgi cells.
Sanford L. Palay, Victoria Chan-Palay
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The apparent simplicity of the cerebellar cortex reflects in part the small number of neuronal types comprised in it. Most descriptions credit it with only five types of nerve cells: Purkinje cells, granule cells, basket cells, stellate cells, and Golgi cells.
Sanford L. Palay, Victoria Chan-Palay
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Acta Neuropathologica, 1982
Purkinje cells from five autopsy cases (a premature newborn infant, a GM1-gangliosidosis, an olivo-ponto-cerebellar atrophy, a multisystem atrophy involving the spinal cord and the brain stem, and a woman of 82 years) were studied using the Golgi impregnation technique.
K, Fujisawa, A, Nakamura
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Purkinje cells from five autopsy cases (a premature newborn infant, a GM1-gangliosidosis, an olivo-ponto-cerebellar atrophy, a multisystem atrophy involving the spinal cord and the brain stem, and a woman of 82 years) were studied using the Golgi impregnation technique.
K, Fujisawa, A, Nakamura
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Purkinje Cell Transplants inShakerMutant Rats with Hereditary Purkinje Cell Degeneration and Ataxia
Experimental Neurology, 1998Shaker mutant rats are characterized by the adult-onset degeneration of cerebellar anterior lobe Purkinje cells and temporally correlated development of ataxia and tremor. Normal E-13 Purkinje cells were transplanted into the anterior cerebellum in adult shaker mutant rats to study donor/host interactions in an animal with adult-onset ...
D L, Tolbert, J, Heckroth
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