Results 1 to 10 of about 12,043,245 (295)

Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity [PDF]

Communications Biology
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans.
Stefano Masoli, Diana Sanchez-Ponce, Nora Vrieler, Karin Abu-Haya, Vitaly Lerner, Tal Shahar, Hermina Nedelescu, Martina Francesca Rizza, Ruth Benavides-Piccione, Javier DeFelipe, Yosef Yarom, Alberto Munoz, Egidio D’Angelo   +12 more
doaj   +8 more sources

The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. [PDF]

PLoS ONE, 2012
In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence.
Michael D Forrest, Mark J Wall, Daniel A Press, Jianfeng Feng   +3 more
doaj   +28 more sources

Dual Characteristics of Apoptosis and Survival in Cerebellar Purkinje Cells Four Days After Transient Global Ischemia [PDF]

Cells
Whether apoptotic cell death occurs in cerebellar Purkinje cells following transient global ischemia remains unclear. Histologic, immunofluorescent and ultramicroscopic methods were used to assess ischemic outcomes in rats.
Zhen He, Alena Savenka, Ada G. Cino Ozuna, Kelly J. Davis, Angel Paredes   +4 more
doaj   +2 more sources

Cardiac Purkinje cells.

Heart Rhythm, 2010
Purkinje cells are specialized for rapid propagation in the heart. Furthermore, Purkinje fibers as the source as well as the perpetuator of arrhythmias is a familiar finding. This is not surprising considering their location in the heart and their unique cell ultrastructure, cell electrophysiology, and mode of excitation-contraction coupling.
P. Boyden, M. Hirose, W. Dun
semanticscholar   +3 more sources

Purkinje Cell Patterning—Insights from Single-Cell Sequencing

Cells, 2022
Despite their homogeneous appearance, Purkinje cells are remarkably diverse with respect to their molecular phenotypes, physiological properties, afferent and efferent connectivity, as well as their vulnerability to insults.
Elizabeth J. Apsley, Esther B. E. Becker
doaj   +4 more sources

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum [PDF]

Cells
Fetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar weight, and cell death.
MaKenna Y. Cealie, James C. Douglas, Hannah K. Swan, Erik D. Vonkaenel, Matthew N. McCall, Paul D. Drew, Ania K. Majewska   +6 more
doaj   +2 more sources

Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum

Neural Development, 2010
Background Cerebellar corticogenesis begins with the assembly of Purkinje cells into the Purkinje plate (PP) by embryonic day 14.5 (E14.5) in mice. Although the dependence of PP formation on the secreted protein Reelin is well known and a prevailing ...
Miyata Takaki, Ono Yuichi, Okamoto Mayumi, Masaoka Makoto, Sakakibara Akira, Kawaguchi Ayano, Hashimoto Mitsuhiro, Ogawa Masaharu   +7 more
doaj   +2 more sources

Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell – DCN Synapse

Frontiers in Synaptic Neuroscience, 2019
Optogenetics is a state-of-the-art tool for interrogating neural circuits. In the cerebellum, Purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (DCN).
Kim M. Gruver, Kim M. Gruver, Alanna J. Watt   +2 more
doaj   +3 more sources

Aging of cerebellar Purkinje cells

Cell and Tissue Research, 2010
Cerebellar Purkinje cells (PCs), the sole output neurons in the cerebellar cortex, play an important role in the cerebellar circuit. PCs appear to be rather sensitive to aging, exhibiting significant changes in both morphology and function during ...
Changzheng Zhang, Qingfeng Zhu, T. Hua
semanticscholar   +3 more sources

Ankfy1 Is Involved in the Maintenance of Cerebellar Purkinje Cells

Frontiers in Cellular Neuroscience, 2021
Purkinje cells are critical for the function of cerebellum. The degeneration of Purkinje cells leads to defects in motion control. We have found that Purkinje cells specifically express Ankfy1 protein during development and in adult.
Liansheng Chang, Shahid Hussain Soomro, Hongfeng Zhang, Hui Fu   +3 more
doaj   +1 more source