Results 1 to 10 of about 43,269 (161)

Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity [PDF]

Communications Biology
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans.
Stefano Masoli, Diana Sanchez-Ponce, Nora Vrieler, Karin Abu-Haya, Vitaly Lerner, Tal Shahar, Hermina Nedelescu, Martina Francesca Rizza, Ruth Benavides-Piccione, Javier DeFelipe, Yosef Yarom, Alberto Munoz, Egidio D’Angelo   +12 more
doaj   +8 more sources

Dual Characteristics of Apoptosis and Survival in Cerebellar Purkinje Cells Four Days After Transient Global Ischemia [PDF]

Cells
Whether apoptotic cell death occurs in cerebellar Purkinje cells following transient global ischemia remains unclear. Histologic, immunofluorescent and ultramicroscopic methods were used to assess ischemic outcomes in rats.
Zhen He, Alena Savenka, Ada G. Cino Ozuna, Kelly J. Davis, Angel Paredes   +4 more
doaj   +2 more sources

Ankfy1 Is Involved in the Maintenance of Cerebellar Purkinje Cells

Frontiers in Cellular Neuroscience, 2021
Purkinje cells are critical for the function of cerebellum. The degeneration of Purkinje cells leads to defects in motion control. We have found that Purkinje cells specifically express Ankfy1 protein during development and in adult.
Liansheng Chang, Shahid Hussain Soomro, Hongfeng Zhang, Hui Fu   +3 more
doaj   +3 more sources

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum [PDF]

Cells
Fetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar weight, and cell death.
MaKenna Y. Cealie, James C. Douglas, Hannah K. Swan, Erik D. Vonkaenel, Matthew N. McCall, Paul D. Drew, Ania K. Majewska   +6 more
doaj   +2 more sources

Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell – DCN Synapse

Frontiers in Synaptic Neuroscience, 2019
Optogenetics is a state-of-the-art tool for interrogating neural circuits. In the cerebellum, Purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (DCN).
Kim M. Gruver, Kim M. Gruver, Alanna J. Watt   +2 more
doaj   +3 more sources

Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. [PDF]

PLoS ONE, 2009
The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a). The phenotype is characterized by an early onset cerebellar ataxia and neurodegeneration, especially apparent in the Purkinje cells. Purkinje cell
Andrew J Sachs, Samuel A David, Neena B Haider, Arne M Nystuen   +3 more
doaj   +1 more source

Feedback inhibition underlies new computational functions of cerebellar interneurons

eLife, 2022
The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling.
Hunter E Halverson, Jinsook Kim, Andrei Khilkevich, Michael D Mauk, George J Augustine   +4 more
doaj   +1 more source

Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses

Scientific Reports, 2021
Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells ...
Weipang Chang, Andrea Pedroni, Reinhard W. Köster, Stefania Giacomello, Konstantinos Ampatzis   +4 more
doaj   +1 more source

Human cerebellar organoids with functional Purkinje cells. [PDF]

Cell Stem Cell
Atamian A, Birtele M, Hosseini N, Nguyen T, Seth A, Del Dosso A, Paul S, Tedeschi N, Taylor R, Coba MP, Samarasinghe R, Lois C, Quadrato G.   +12 more
europepmc   +2 more sources

Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

eLife, 2021
Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially vulnerable and likely instigate disease by impairing the function ...
Meike E van der Heijden, Elizabeth P Lackey, Ross Perez, Fatma S Ișleyen, Amanda M Brown, Sarah G Donofrio, Tao Lin, Huda Y Zoghbi, Roy V Sillitoe   +8 more
doaj   +1 more source