Results 31 to 40 of about 4,781,201 (273)

Quantification of the density of cooperative neighboring synapses required to evoke endocannabinoid signaling [PDF]

, 2014
The spatial pattern of synapse activation may impact on synaptic plasticity. This applies to the synaptically-evoked endocannabinoid-mediated short-term depression at the parallel fiber (PF) to Purkinje cell synapse, the occurrence of which requires ...
Pachoud, B, Bergerot, A, Pachoud, B., Knöpfel, T, Sharma, P, Marcaggi, P, Bergerot, A., Sharma, P., Marcaggi, Païkan, Knöpfel, T.   +9 more
core   +1 more source

Initiation of simple and complex spikes in cerebellar Purkinje cells [PDF]

, 2010
Cerebellar Purkinje cells produce two distinct forms of action potential output: simple and complex spikes. Simple spikes occur spontaneously or are driven by parallel fibre input, while complex spikes are activated by climbing fibre input.
Clark, BA, Clark, Beverley A., Häusser, M, Gründemann, J, Roth, A, Clark, Beverley A, Palmer, LM, Palmer, Lucy M., Stuart, Greg J., Stuart, Gregory J, Stuart, GJ, Palmer, Lucy, Grundemann, Jan, Hausser, Michael, Roth, Arnd   +14 more
core   +1 more source

Calsequestrin in Purkinje cells of mammalian cerebellum [PDF]

, 2023
: Cerebellum is devoted to motor coordination and cognitive functions. Endoplasmic reticulum is the largest intracellular calcium store involved in all neuronal functions.
Greotti, Elisa, Paradiso, Beatrice, Furlan, Sandra, Nori, Alessandra, Volpe, Pompeo, Volpe Pompeo, Nori Alessandra, Furlan Sandra, Paradiso Beatrice, Greotti Elisa, Beatrice Paradiso, Elisa Greotti, Alessandra Nori, Pompeo Volpe, Sandra Furlan   +14 more
core   +1 more source

BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivo. [PDF]

PLoS ONE, 2009
Calcium signaling plays a central role in normal CNS functioning and dysfunction. As cerebellar Purkinje cells express the major regulatory elements of calcium control and represent the sole integrative output of the cerebellar cortex, changes in neural ...
Guy Cheron, Matthias Sausbier, Ulrike Sausbier, Winfried Neuhuber, Peter Ruth, Bernard Dan, Laurent Servais   +6 more
doaj   +1 more source

Human cerebellar organoids with functional Purkinje cells. [PDF]

Cell Stem Cell
Atamian A, Birtele M, Hosseini N, Nguyen T, Seth A, Del Dosso A, Paul S, Tedeschi N, Taylor R, Coba MP, Samarasinghe R, Lois C, Quadrato G.   +12 more
europepmc   +2 more sources

Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.

PLoS ONE, 2011
Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single ...
Megumi Kaneko, Kazuhiko Yamaguchi, Mototsugu Eiraku, Motohiko Sato, Norio Takata, Yoshimoto Kiyohara, Masayoshi Mishina, Hajime Hirase, Tsutomu Hashikawa, Mineko Kengaku   +9 more
doaj   +1 more source

Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death

Molecular Brain, 2009
Purkinje cells are a class of specialized neurons in the cerebellum, and are among the most metabolically active of all neurons, as they receive immense synaptic stimulation, and provide the only efferent output from the cerebellum.
Chakrabarti Lisa, Eng Jeremiah, Ivanov Nishi, Garden Gwenn A, La Spada Albert R   +4 more
doaj   +1 more source

Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. [PDF]

PLoS ONE, 2015
Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast ...
John E Greenlee, Susan A Clawson, Kenneth E Hill, Blair Wood, Stacey L Clardy, Ikuo Tsunoda, Noel G Carlson   +6 more
doaj   +1 more source

The Purkinje–myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT

JCI Insight, 2022
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs).
Daniel J. Blackwell, Michela Faggioni, Matthew J. Wleklinski, Nieves Gomez-Hurtado, Raghav Venkataraman, Chelsea E. Gibbs, Franz J. Baudenbacher, Shiaoching Gong, Glenn I. Fishman, Patrick M. Boyle, Karl Pfeifer, Bjorn C. Knollmann   +11 more
doaj   +1 more source

Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes

, 2023
Arrhythmias of the heart are currently treated by implanting electronic pacemakers and defibrillators. Unmodified adipose tissue-derived stem cells (ASCs) have the potential to differentiate into all three germ layers but have not yet been tested for the
Tahereh Karimi, Vladimir N. Potaman, Eckhard U. Alt, Zhizhong Pan   +3 more
core   +1 more source