Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy. [PDF]
PLoS ONE, 2016 The specialised conducting tissues present in the ventricles are responsible for the fast distribution of the electrical impulse from the atrio-ventricular node to regions in the subendocardial myocardium.
Daniel Romero +3 more
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THE FINE STRUCTURE OF THE PURKINJE CELL [PDF]
The Journal of Cell Biology, 1963 This paper describes the fine structure of the Purkinje cell of the rat cerebellum after fixation by perfusion with 1 per cent buffered osmium tetroxide. Structures described include a large Golgi apparatus, abundant Nissl substance, mitochondria, multivesicular bodies, osmiophilic granules, axodendritic and axosomatic synapses, the nucleus, the ...
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Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
PLoS ONE, 2011 Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single ...
Megumi Kaneko +9 more
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BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivo. [PDF]
PLoS ONE, 2009 Calcium signaling plays a central role in normal CNS functioning and dysfunction. As cerebellar Purkinje cells express the major regulatory elements of calcium control and represent the sole integrative output of the cerebellar cortex, changes in neural ...
Guy Cheron +6 more
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Neural Development, 2010 Background Cerebellar corticogenesis begins with the assembly of Purkinje cells into the Purkinje plate (PP) by embryonic day 14.5 (E14.5) in mice. Although the dependence of PP formation on the secreted protein Reelin is well known and a prevailing ...
Miyata Takaki +7 more
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Thyroid Hormone Induces PGC-1α during Dendritic Outgrowth in Mouse Cerebellar Purkinje Cells
Frontiers in Cellular Neuroscience, 2017 Thyroid hormone 3,3′,5-Triiodo-L-thyronine (T3) is essential for proper brain development. Perinatal loss of T3 causes severe growth defects in neurons and glia, including strong inhibition of dendrite formation in Purkinje cells in the cerebellar cortex.
Tetsu Hatsukano +7 more
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Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. [PDF]
PLoS ONE, 2015 Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast ...
John E Greenlee +6 more
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Molecular Brain, 2009 Purkinje cells are a class of specialized neurons in the cerebellum, and are among the most metabolically active of all neurons, as they receive immense synaptic stimulation, and provide the only efferent output from the cerebellum.
Chakrabarti Lisa +4 more
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The Purkinje–myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT
JCI Insight, 2022 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs).
Daniel J. Blackwell +11 more
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Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo
Cell Reports, 2020 Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
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