Developmental Regulation of Small-Conductance Ca²⁺-Activated K⁺ Channel Expression and Function in Rat Purkinje Neurons [PDF]
, 2002 Calcium transients play an important role in the early and later phases of differentiation and maturation of single neurons and neuronal networks. Small-conductance calcium-activated potassium channels of the SK type modulate membrane excitability and ...
Stocker, M +19 more
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Frontiers in Aging Neuroscience, 2022 MRE11, RAD50, and NBS1 form the MRN complex in response to DNA damage to activate ATM, a gene responsible for Ataxia-Telangiectasia (A-T). Loss of any components of the MRN complex compromises cell life.
Mingmei Ding +11 more
doaj +1 more source
Distinct and common functions of mTORC1 and mTORC2 in Purkinje cells [PDF]
, 2015 In mammalian cells, the serine/threonine protein kinase mTOR (mammalian target of rapamycin) is present in two complexes, called mTORC1 and mTORC2. While several of the components are common to both complexes, raptor and rictor are only associated with ...
Angliker, Nico
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Numbers and percentages of Purkinje cells in granular/Purkinje and monocular layers.
, 2023 Numbers and percentages of Purkinje cells in granular/Purkinje and monocular layers.
Kanae Karita (15354153) +7 more
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Positional changes of pericentromeric heterochromatin and nucleoli in postmitotic Purkinje cells during murine cerebellum development [PDF]
, 2004 Previous studies revealed changes of pericentromeric heterochromatin arrangements in postmitotic Purkinje cells (PCs) during postnatal development in the mouse cerebellum (Manuelidis, 1985; Martou and De Boni, 2000). Here, we performed vibratome sections
Knoth, R. +4 more
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Frontiers in Cellular Neuroscience, 2021 Patterned cell death is a common feature of many neurodegenerative diseases. In patients with autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and mouse models of ARSACS, it has been observed that Purkinje cells in anterior cerebellar ...
Brenda Toscano Márquez +7 more
doaj +1 more source
β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees:Protein complex critical for sodium channel activity is impaired by SCA5-associated mutations [PDF]
, 2014 Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival.
Perkins, Emma M. +6 more
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Neurobiology of Disease, 2011 Alteration in mitochondrial dynamics has been implicated in many neurodegenerative diseases. Mitochondrial apoptosis inducing factor (AIF) plays a key role in multiple cellular and disease processes.
Seung-Hyuk Chung +4 more
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Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy. [PDF]
PLoS ONE, 2016 The specialised conducting tissues present in the ventricles are responsible for the fast distribution of the electrical impulse from the atrio-ventricular node to regions in the subendocardial myocardium.
Daniel Romero +3 more
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mTORC2 controls neuron size and Purkinje cell morphology independent of mTORC1 [PDF]
, 2012 Prenatal brain development is mainly accomplished by extensive proliferation of neuronal precursor cells whereas postnatal brain growth in mammals is mainly mediated by the growth of those post-mitotic nerve cells.
Thomanetz, Venus
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