Results 11 to 20 of about 12,043,245 (295)
Encoding of action by the Purkinje cells of the cerebellum
Nature, 2015 Execution of accurate eye movements depends critically on the cerebellum, suggesting that the major output neurons of the cerebellum, Purkinje cells, may predict motion of the eye.
David J. Herzfeld +3 more
semanticscholar +3 more sources
Selective Optogenetic Control of Purkinje Cells in Monkey Cerebellum.
Neuron, 2017 Yasmine El-Shamayleh +3 more
semanticscholar +3 more sources
Feedback inhibition underlies new computational functions of cerebellar interneurons
eLife, 2022 The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling.
Hunter E Halverson +4 more
doaj +1 more source
Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. [PDF]
PLoS ONE, 2009 The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a). The phenotype is characterized by an early onset cerebellar ataxia and neurodegeneration, especially apparent in the Purkinje cells. Purkinje cell
Andrew J Sachs +3 more
doaj +1 more source
Neuroscience, 2020 Cerebellar development has a remarkably protracted morphogenetic timeline that is coordinated by multiple cell types. Here, we discuss the intriguing cellular consequences of interactions between inhibitory Purkinje cells and excitatory granule cells ...
Meike E van der Heijden, R. Sillitoe
semanticscholar +1 more source
Scientific Reports, 2021 Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells ...
Weipang Chang +4 more
doaj +1 more source
Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to purkinje cell synapse [PDF]
, 2003 We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket and
Dean, I., Edwards, F.A., Robertson, S.J.
core +3 more sources
Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons
eLife, 2021 Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially vulnerable and likely instigate disease by impairing the function ...
Meike E van der Heijden +8 more
doaj +1 more source
Spiral-wave dynamics in a mathematical model of human ventricular tissue with myocytes and Purkinje fibers [PDF]
, 2017 We present systematic numerical studies of the possible effects of the coupling of human endocardial and Purkinje cells at cellular and two-dimensional tissue levels.
Nayak, Alok Ranjan +2 more
core +1 more source
Disease Models & Mechanisms, 2018 Many cerebellar-induced neurological disorders, such as ataxias and cerebellar-induced dystonias, are associated with abnormal Purkinje cell activity. In tottering mice, a well-established mouse model of episodic ataxia type 2 (EA2), cerebellar Purkinje ...
Esra Tara +3 more
doaj +1 more source