Results 41 to 50 of about 12,043,245 (295)

Attentive Learning of Sequential Handwriting Movements: A Neural Network Model [PDF]

, 2000
Defense Advanced research Projects Agency and the Office of Naval Research (N00014-95-1-0409, N00014-92-J-1309); National Science Foundation (IRI-97-20333); National Institutes of Health (I-R29-DC02952-01)
A. Berardelli, A. Dagher, A. Thomassen, A. Thomassen, A.B. Schwartz, A.P. Georgopoulos, A.P. Georgopoulos, A.P. Georgopoulos, A.P. Georgopoulos, A.W. Gemmert van, B.D. Kretschmer, C. Fowler, C. Ghez, C.E. Wright, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Ostry, D. Zipser, D.M. Bannerman, D.V. Buonomano, E. Bizzi, E.M. Arroyo-Anllo, F. Chapeau-Blondeau, F. Lacquaniti, F. Mussa-Ivaldi, F. Richer, F.B. Horak, F.B. Horak, F.N. Freeman, G.P. Galen van, G.P. Galen van, G.T. Bartha, I. Hertrich, J. Alston, J. Doyon, J. Fiala, J. Schillings, J. Soechting, J. Wann, J.A. Freeman, J.B. Hopfinger, J.D. Coltz, J.D. Coltz, J.F. Kalaska, J.I. Simpson, J.J. Waite, J.M. Hollerbach, J.P. Wann, J.W. Moore, K. Greer, M. Hallett, M. Iacoboni, M. Ito, M. Ito, M. Ito, M. Jueptner, M. Jueptner, M. Jueptner, M.G. Pleskacheva, M.T. Turvey, N. Bernstein, N. Sadato, O. Oscarsson, P. Morasso, P. Morasso, P. Morasso, P. Vindras, P.C. Burns, Q.G. Fu, R. Andersen, R. Andersen, R. Caminiti, R. Gellman, R. Kawashima, R. Plamondon, R.S. Turner, R.S. Turner, S. Chieffi, S. Edelman, S. Grossberg, S. Grossberg, S. Grossberg, S. Jaffe, S. Ohman, S.P. Perrett, T.J. Ebner, T.L. Zhou, T.S. Buchanan, W. Abend, X. Lu   +93 more
core   +2 more sources

Bidirectional Plasticity of Purkinje Cells Matches Temporal Features of Learning

Journal of Neuroscience, 2014
Many forms of learning require temporally ordered stimuli. In Pavlovian eyeblink conditioning, a conditioned stimulus (CS) must precede the unconditioned stimulus (US) by at least about 100 ms for learning to occur.
Daniel Z. Wetmore, Dan-Anders Jirenhed, A. Rasmussen, F. Johansson, M. Schnitzer, G. Hesslow   +5 more
semanticscholar   +1 more source

Purkinje Cells Pathology in Alzheimer’s Disease [PDF]

American Journal of Alzheimer's Disease & Other Dementias®, 2019
Alzheimer’s disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic ...
Ioannis Mavroudis, Foivos Petridis, Dimitrios Kazis, Samuel N. Njau, Vasiliki Costa, Stavros J. Baloyannis   +5 more
openaire   +2 more sources

Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.

PLoS ONE, 2011
Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single ...
Megumi Kaneko, Kazuhiko Yamaguchi, Mototsugu Eiraku, Motohiko Sato, Norio Takata, Yoshimoto Kiyohara, Masayoshi Mishina, Hajime Hirase, Tsutomu Hashikawa, Mineko Kengaku   +9 more
doaj   +1 more source

Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death

Molecular Brain, 2009
Purkinje cells are a class of specialized neurons in the cerebellum, and are among the most metabolically active of all neurons, as they receive immense synaptic stimulation, and provide the only efferent output from the cerebellum.
Chakrabarti Lisa, Eng Jeremiah, Ivanov Nishi, Garden Gwenn A, La Spada Albert R   +4 more
doaj   +1 more source

The Purkinje–myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT

JCI Insight, 2022
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs).
Daniel J. Blackwell, Michela Faggioni, Matthew J. Wleklinski, Nieves Gomez-Hurtado, Raghav Venkataraman, Chelsea E. Gibbs, Franz J. Baudenbacher, Shiaoching Gong, Glenn I. Fishman, Patrick M. Boyle, Karl Pfeifer, Bjorn C. Knollmann   +11 more
doaj   +1 more source

Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. [PDF]

PLoS ONE, 2015
Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast ...
John E Greenlee, Susan A Clawson, Kenneth E Hill, Blair Wood, Stacey L Clardy, Ikuo Tsunoda, Noel G Carlson   +6 more
doaj   +1 more source

Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo

Cell Reports, 2020
Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
doaj   +1 more source

Firing Dynamics of Cerebellar Purkinje Cells [PDF]

Journal of Neurophysiology, 2007
Knowledge of intrinsic neuronal firing dynamics is a critical first step to establishing an accurate biophysical model of any neuron. In this study we examined cerebellar Purkinje cells to determine the bifurcations likely to underlie firing dynamics within a biophysically realistic and experimentally supported model.
Fernando R, Fernandez, Jordan D T, Engbers, Ray W, Turner   +2 more
openaire   +2 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source