Results 51 to 60 of about 4,781,201 (273)

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Investigating the Contribution of BK Channel in the Firing Activity of Cerebellar Purkinje Cells Using Computer Simulation

مجله دانشکده پزشکی اصفهان, 2012
Background: BK channels are highly conductive calcium (Ca2+)-activated potassium (K+) channels. These channels are available on the membrane of many types of neurons including cerebellar Purkinje cells. Several experimental studies have used iberiotoxin,
Hassan Zolfeghar Didani, Mehdi Kargarfard, Vahid Karim Azad Marjani   +2 more
doaj   +2 more sources

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum

Cells
Fetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar weight, and cell death.
MaKenna Y. Cealie, James C. Douglas, Hannah K. Swan, Erik D. Vonkaenel, Matthew N. McCall, Paul D. Drew, Ania K. Majewska   +6 more
doaj   +1 more source

Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

eLife, 2019
The cerebellum integrates sensory stimuli and motor actions to enable smooth coordination and motor learning. Here we harness the innate behavioral repertoire of the larval zebrafish to characterize the spatiotemporal dynamics of feature coding across ...
Laura D Knogler, Andreas M Kist, Ruben Portugues   +2 more
doaj   +1 more source

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Mesenchymal stem cells rescue Purkinje cells and improve motor functions in a mouse model of cerebellar ataxia

Neurobiology of Disease, 2010
Mesenchymal stem cells have been proven to be potentially effective in the treatment of a large variety of diseases, including neurodegenerative disorders.
Jonathan Jones, Jesús Jaramillo-Merchán, Carlos Bueno, Diego Pastor, MariCarmen Viso-León, Salvador Martínez   +5 more
doaj   +1 more source

AI‐Powered Smart Displays and AR Glasses: Perspectives and Challenges

Advanced Intelligent Systems, EarlyView.
This perspective examines how AI is reshaping smart displays and AR glasses. The latest in image‐quality enhancement, sensor‐integrated display optimization, and physiological sensing in display systems, followed by AI‐assisted AR technologies including waveguide optimization, image compensation, foveated rendering, and multimodal sensing, is discussed.
Luke Benoit, Yizhou Qian, Yi‐Chien Chen, Ziyang Shen, Po‐Sheng Chiu, Youngeon Lee, Cheng‐Han Ke, Chih‐Lung Lin, Shin‐Tson Wu   +8 more
wiley   +1 more source

Human aldolase C: gene transcriptional regulation and protein functional role [PDF]

, 2011
Aldolase C is the brain-specific aldolase isoenzyme. In the human brain, aldolase C messenger and protein are expressed in a stripe-like pattern in the Purkinje cells of the cerebellum, in the inferior olives and in the Goll and Burdach nuclei of the ...
Serio, Laura
core   +1 more source

Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf, Andrea Accogli, Fadi F. Hamdan, Francesca Nardecchia, Toshiyuki Itai, Kenneth A. Myers, Christine Saint Martin, Myriam Srour   +7 more
wiley   +1 more source