Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates
Molecular Therapy: Methods & Clinical Development, 2017 Cell-type-specific promoters in combination with viral vectors and gene-editing technology permit efficient gene manipulation in specific cell populations. Cerebellar Purkinje cells play a pivotal role in cerebellar functions.
Keisuke Nitta +3 more
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The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. [PDF]
PLoS ONE, 2012 In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence.
Michael D Forrest +3 more
doaj +33 more sources
Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. [PDF]
PLoS ONE, 2015 Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast ...
John E Greenlee +6 more
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Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo
Cell Reports, 2020 Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
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Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia [PDF]
Acta Neuropathologica Communications, 2016 Purkinje cell pathology is a common finding in a range of inherited and acquired cerebellar disorders, with the degree of Purkinje cell injury dependent on the underlying aetiology.
Cook, Amelia +5 more
core +4 more sources
eLife, 2020 Tremor is currently ranked as the most common movement disorder. The brain regions and neural signals that initiate the debilitating shakiness of different body parts remain unclear.
Amanda M Brown +5 more
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Purkinje cell loss in essential tremor: Random sampling quantification and nearest neighbor analysis
Movement Disorders, 2016 Purkinje cell loss has been documented in some, although not all, postmortem studies of essential tremor. Hence, there is considerable controversy concerning the presence of Purkinje cell loss in this disease. To date, few studies have been performed.
Etty Cortes +2 more
exaly +2 more sources
Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period [PDF]
Annals of Clinical and Translational NeurologyObjective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations.
Chloë A. Kerridge +4 more
doaj +2 more sources
Purkinje Cell Patterning—Insights from Single-Cell Sequencing
Cells, 2022 Despite their homogeneous appearance, Purkinje cells are remarkably diverse with respect to their molecular phenotypes, physiological properties, afferent and efferent connectivity, as well as their vulnerability to insults.
Elizabeth J. Apsley, Esther B. E. Becker
doaj +3 more sources
Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum
Brain, 2014 Chi-Ying Lin +2 more
exaly +2 more sources