Molecular Brain, 2009 Purkinje cells are a class of specialized neurons in the cerebellum, and are among the most metabolically active of all neurons, as they receive immense synaptic stimulation, and provide the only efferent output from the cerebellum.
Chakrabarti Lisa +4 more
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Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. [PDF]
PLoS ONE, 2009 The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a). The phenotype is characterized by an early onset cerebellar ataxia and neurodegeneration, especially apparent in the Purkinje cells. Purkinje cell
Andrew J Sachs +3 more
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Neuronal death mechanisms in cerebellar Purkinje cells [PDF]
, 2008 Neuropathologies often involve apoptosis and autophagy, two mechanisms of programmed cell death which require activation of specific signaling pathways.
HEITZ, Stéphane Alphonse +1 more
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Mathematical model of bursting in dissociated Purkinje neurons [PDF]
, 2013 In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst.
Forrest Michael D. +2 more
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The Purkinje cell; 2008 style [PDF]
Journal of Molecular and Cellular Cardiology, 2008 Cardiac Purkinje fibers, due to their unique anatomical location, cell structure and electrophysiologic characteristics, play an important role in cardiac conduction and arrhythmogenesis. Purkinje cell action potentials are longer than their ventricular counterpart, and display two levels of resting potential.
Wen, Dun, Penelope A, Boyden
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Development of axon-target specificity of ponto-cerebellar afferents.
PLoS Biology, 2011 The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron
Anna Kalinovsky +6 more
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Mechanisms and consequences of reduced dendritic growth of cerebellar Purkinje cells [PDF]
, 2012 The cerebellum is a brain region crucial for coordination and motor learning. Being the principal output cell of the cerebellar cortex, Purkinje cell loss and degeneration play an important role in many cerebellar diseases.
Gugger, Olivia S.
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Establishment of topographic circuit zones in the cerebellum of scrambler mutant mice
Frontiers in Neural Circuits, 2013 The cerebellum is organized into zonal circuits that are thought to regulate ongoing motor behavior. Recent studies suggest that neuronal birthdates, gene expression patterning, and apoptosis control zone formation.
Stacey L Reeber +3 more
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β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees:Protein complex critical for sodium channel activity is impaired by SCA5-associated mutations [PDF]
, 2014 Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival.
Perkins, Emma M. +6 more
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Developmental Regulation of Small-Conductance Ca²⁺-Activated K⁺ Channel Expression and Function in Rat Purkinje Neurons [PDF]
, 2002 Calcium transients play an important role in the early and later phases of differentiation and maturation of single neurons and neuronal networks. Small-conductance calcium-activated potassium channels of the SK type modulate membrane excitability and ...
Stocker, M +16 more
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