Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity [PDF]
Communications BiologyPurkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans.
Stefano Masoli +12 more
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The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. [PDF]
PLoS ONE, 2012 In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence.
Michael D Forrest +3 more
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Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo
Cell Reports, 2020 Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
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Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse [PDF]
Frontiers in Systems Neuroscience, 2014 Article deposited according to Frontiers policy for Frontiers in Systems Neuroscience: http://www.frontiersin.org/about/faq June 18 ...
Richard eHawkes, Richard Hawkes
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Frontiers in Synaptic Neuroscience, 2019 Optogenetics is a state-of-the-art tool for interrogating neural circuits. In the cerebellum, Purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (DCN).
Kim M. Gruver +2 more
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Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to purkinje cell synapse [PDF]
, 2003 We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket and
Isabel Dean +5 more
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Mathematical model of bursting in dissociated Purkinje neurons [PDF]
, 2013 In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst.
Forrest Michael D. +2 more
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Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. [PDF]
PLoS ONE, 2009 The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a). The phenotype is characterized by an early onset cerebellar ataxia and neurodegeneration, especially apparent in the Purkinje cells. Purkinje cell
Andrew J Sachs +3 more
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Neuronal death mechanisms in cerebellar Purkinje cells [PDF]
, 2008 Neuropathologies often involve apoptosis and autophagy, two mechanisms of programmed cell death which require activation of specific signaling pathways.
HEITZ, Stéphane Alphonse +1 more
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Development of axon-target specificity of ponto-cerebellar afferents.
PLoS Biology, 2011 The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron
Anna Kalinovsky +6 more
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