Results 11 to 20 of about 12,040,588 (301)

Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse [PDF]

Frontiers in Systems Neuroscience, 2014
The cerebellar cortex comprises a stereotyped array of transverse zones and parasagittal stripes, built around multiple Purkinje cell subtypes, which is highly conserved across birds and mammals. This architecture is revealed in the restricted expression
R. Hawkes
semanticscholar   +5 more sources

Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell – DCN Synapse

Frontiers in Synaptic Neuroscience, 2019
Optogenetics is a state-of-the-art tool for interrogating neural circuits. In the cerebellum, Purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (DCN).
Kim M. Gruver, Kim M. Gruver, Alanna J. Watt   +2 more
doaj   +3 more sources

Purkinje Cell [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity

Communications Biology
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans.
Stefano Masoli, Diana Sanchez-Ponce, Nora Vrieler, Karin Abu-Haya, Vitaly Lerner, Tal Shahar, Hermina Nedelescu, Martina Francesca Rizza, Ruth Benavides-Piccione, Javier DeFelipe, Yosef Yarom, Alberto Munoz, Egidio D’Angelo   +12 more
doaj   +7 more sources

Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor

Brain, 2014
Elan D Louis, Etty Cortes, Phyllis L Faust   +2 more
exaly   +2 more sources

Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains

Brain, 2013
Etty Cortes, Phyllis L Faust, Elan D Louis   +2 more
exaly   +2 more sources

A mitochondrial-targeted antioxidant (MitoQ) improves motor coordination and reduces Purkinje cell death in a mouse model of ARSACS

Neurobiology of Disease, 2023
Mitochondrial deficits have been observed in animal models of Autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) and in patient-derived fibroblasts. We investigated whether mitochondrial function could be restored in Sacs−/− mice, a mouse
Brenda Toscano Márquez, Tsz Chui Sophia Leung, Jeanette Hui, François Charron, R. Anne McKinney, Alanna J. Watt   +5 more
doaj   +1 more source

Losing the beat: contribution of Purkinje cell firing dysfunction to disease, and its reversal.

Neuroscience, 2020
The cerebellum is a brain structure that is highly interconnected with other brain regions. There are many contributing factors to cerebellar-related brain disease, such as altered afferent input, local connectivity, and/or cerebellar output.
Anna A. Cook, Eviatar Fields, A. Watt
semanticscholar   +1 more source

Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to purkinje cell synapse [PDF]

, 2003
We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket and
Dean, I., Edwards, F.A., Robertson, S.J.
core   +3 more sources

A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning

Frontiers in Computational Neuroscience, 2023
The cerebellar Purkinje cell controlling eyeblinks can learn, remember, and reproduce the interstimulus interval in a classical conditioning paradigm. Given temporally separated inputs, the cerebellar Purkinje cell learns to pause its tonic inhibition of
Matthew Ricci, Junkyung Kim, Fredrik Johansson   +2 more
doaj   +1 more source