Results 31 to 40 of about 12,040,588 (301)

The Purkinje cell; 2008 style [PDF]

open access: yesJournal of Molecular and Cellular Cardiology, 2008
Cardiac Purkinje fibers, due to their unique anatomical location, cell structure and electrophysiologic characteristics, play an important role in cardiac conduction and arrhythmogenesis. Purkinje cell action potentials are longer than their ventricular counterpart, and display two levels of resting potential.
Wen, Dun, Penelope A, Boyden
openaire   +2 more sources

Development of axon-target specificity of ponto-cerebellar afferents.

open access: yesPLoS Biology, 2011
The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron
Anna Kalinovsky   +6 more
doaj   +1 more source

Calcium Signaling, PKC Gamma, IP3R1 and CAR8 Link Spinocerebellar Ataxias and Purkinje Cell Dendritic Development

open access: yesCurrent Neuropharmacology, 2017
Background Spinocerebellar ataxias (SCAs) are a group of cerebellar diseases characterized by progressive ataxia and cerebellar atrophy. Several forms of SCAs are caused by missense mutations or deletions in genes related to calcium signaling in Purkinje
Etsuko Shimobayashi, J. Kapfhammer
semanticscholar   +1 more source

Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health

open access: yesFrontiers in Aging Neuroscience, 2023
Dietary restriction (DR) is a universal anti-aging intervention, which reduces age-related nervous system pathologies and neurological decline. The degree to which the neuroprotective effect of DR operates by attenuating cell intrinsic degradative ...
María Björk Birkisdóttir   +12 more
doaj   +1 more source

Fear conditioning-related changes in cerebellar Purkinje cell activities in goldfish

open access: yesBehavioral and Brain Functions, 2012
Background Fear conditioning-induced changes in cerebellar Purkinje cell responses to a conditioned stimulus have been reported in rabbits. It has been suggested that synaptic long-term potentiation and the resulting increases in firing rates of Purkinje
Yoshida Masayuki, Kondo Hiroki
doaj   +1 more source

Effect of gestational diabetes on neuronal cells in rat cerebellum in early postnatal life [PDF]

open access: yes, 2014
Previous study has shown the adverse effects of gestational diabetes on hippocampal neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on rat cerebellum in early postnatal life. In this experimental
Ghafari, S.   +3 more
core   +1 more source

Purkinje cell collaterals enable output signals from the cerebellar cortex to feed back to Purkinje cells and interneurons

open access: yesNeuron, 2016
Summary Purkinje cells (PCs) provide the sole output from the cerebellar cortex. Although PCs are well characterized on many levels, surprisingly little is known about their axon collaterals and their target neurons within the cerebellar cortex.
L. Witter   +4 more
semanticscholar   +1 more source

Reading out a spatiotemporal population code by imaging neighbouring parallel fibre axons in vivo. [PDF]

open access: yes, 2015
The spatiotemporal pattern of synaptic inputs to the dendritic tree is crucial for synaptic integration and plasticity. However, it is not known if input patterns driven by sensory stimuli are structured or random.
Häusser, M, Wilms, CD
core   +1 more source

Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

open access: yesNature, 2012
Autism spectrum disorders (ASDs) are highly prevalent neurodevelopmental disorders, but the underlying pathogenesis remains poorly understood. Recent studies have implicated the cerebellum in these disorders, with post-mortem studies in ASD patients ...
Peter T. Tsai   +9 more
semanticscholar   +1 more source

Information theoretical analysis of differences in information transmission in cerebellar Purkinje cells across species [PDF]

open access: yes, 2014
from the 23rd Annual Computational Neuroscience Meeting CNS 2014. © 2014 Kidd et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses ...
Daniel Polani   +6 more
core   +1 more source

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