Cerebellar Cortex, Purkinje Cell Layer [PDF]
, 2008 This report contains a summary of expression patterns for genes that are enriched in the Purkinje cell layer (CBXpu) of the cerebellum. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project.
Angela L. Guillozet-Bongaarts +6 more
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Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.
PLoS Computational Biology, 2019 Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses ...
Niceto R Luque +4 more
doaj +1 more source
eLife, 2020 Tremor is currently ranked as the most common movement disorder. The brain regions and neural signals that initiate the debilitating shakiness of different body parts remain unclear.
Amanda M Brown +5 more
doaj +1 more source
Quantification of the density of cooperative neighboring synapses required to evoke endocannabinoid signaling [PDF]
, 2014 The spatial pattern of synapse activation may impact on synaptic plasticity. This applies to the synaptically-evoked endocannabinoid-mediated short-term depression at the parallel fiber (PF) to Purkinje cell synapse, the occurrence of which requires ...
Pachoud, B +9 more
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Studying cerebellar circuits by remote control of selected neuronal types with GABA-A receptors
Frontiers in Molecular Neuroscience, 2009 Although GABA-A receptor-mediated inhibition of cerebellar Purkinje cells by molecular layer interneurons (MLIs) has been studied intensely on the cellular level, it has remained unclear how this inhibition regulates cerebellum-dependent behaviour.
William Wisden +3 more
doaj +1 more source
Positional changes of pericentromeric heterochromatin and nucleoli in postmitotic Purkinje cells during murine cerebellum development [PDF]
, 2004 Previous studies revealed changes of pericentromeric heterochromatin arrangements in postmitotic Purkinje cells (PCs) during postnatal development in the mouse cerebellum (Manuelidis, 1985; Martou and De Boni, 2000). Here, we performed vibratome sections
Knoth, R. +4 more
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Basket to Purkinje Cell Inhibitory Ephaptic Coupling Is Abolished in Episodic Ataxia Type 1
, 2023 Dominantly inherited missense mutations of the KCNA1 gene, which encodes the KV1.1 potassium channel subunit, cause Episodic Ataxia type 1 (EA1).
Henry G. S. Martin, Dimitri M. Kullmann
core +2 more sources
Neurobiology of Disease, 2011 Alteration in mitochondrial dynamics has been implicated in many neurodegenerative diseases. Mitochondrial apoptosis inducing factor (AIF) plays a key role in multiple cellular and disease processes.
Seung-Hyuk Chung +4 more
doaj +1 more source
Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration
Neurobiology of Disease, 2011 Tuberous sclerosis complex (TSC) is a neurogenetic disorder that often causes brain abnormalities leading to epilepsy, developmental delay, and autism.
R. Michelle Reith +4 more
doaj +1 more source
Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez +5 more
wiley +1 more source