Results 51 to 60 of about 48,590 (271)

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

eLife, 2019
The cerebellum integrates sensory stimuli and motor actions to enable smooth coordination and motor learning. Here we harness the innate behavioral repertoire of the larval zebrafish to characterize the spatiotemporal dynamics of feature coding across ...
Laura D Knogler, Andreas M Kist, Ruben Portugues   +2 more
doaj   +1 more source

Mitochondrial morphogenesis, dendrite development, and synapse formation in cerebellum require both Bcl-w and the glutamate receptor delta2. [PDF]

PLoS Genetics, 2008
Bcl-w belongs to the prosurvival group of the Bcl-2 family, while the glutamate receptor delta2 (Grid2) is an excitatory receptor that is specifically expressed in Purkinje cells, and required for Purkinje cell synapse formation.
Qiong A Liu, Helen Shio
doaj   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Cerebellar LTD and pattern recognition by Purkinje cells [PDF]

, 2007
Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns.
De Zeeuw, C., De Zeeuw, Chris I., Hoebeek, F. E., Mittmann, W., Hoebeek, Freek, Silver, RA, Steuber, V, H\ue4usser, Michael, de Zeeuw, Chris, Steuber, V., Hoebeek, F., Mittmann, Wolfgang, Silver, R. Angus, Silver, R., De Schutter, Erik, Hausser, Michael, Häusser, M., Mittmann, W, De Schutter, E, Steuber, Volker, Hoebeek, Freek E., De Schutter, E., Hausser, M, De Zeeuw, C. I.   +23 more
core   +1 more source

Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells

FASEB BioAdvances, 2020
The brain produces steroids de novo from cholesterol, so‐called “neurosteroids.” The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from cholesterol in
Kazuyoshi Tsutsui, Shogo Haraguchi
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Dendritic spikes control synaptic plasticity and somatic output in cerebellar Purkinje cells. [PDF]

, 2007
Neurons receive the vast majority of their input onto their dendrites. Dendrites express a plethora of voltage-gated channels. Regenerative, local events in dendrites and their role in the information transformation in single neurons are, however, poorly
Rancz, E.A., Rancz, Ede Attila
core  

GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function [PDF]

, 2017
Summary: During embryonic development of the cerebellum, Purkinje cells (PCs) migrate away from the ventricular zone to form the PC plate. The mechanisms that regulate PC migration are incompletely understood.
Carlos F. Ibáñez, Sergaki, MC, Maria Christina Sergaki, Ibáñez, CF   +3 more
core   +1 more source

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum

Cells
Fetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar weight, and cell death.
MaKenna Y. Cealie, James C. Douglas, Hannah K. Swan, Erik D. Vonkaenel, Matthew N. McCall, Paul D. Drew, Ania K. Majewska   +6 more
doaj   +1 more source