Results 51 to 60 of about 5,279,387 (270)

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates

Molecular Therapy: Methods & Clinical Development, 2017
Cell-type-specific promoters in combination with viral vectors and gene-editing technology permit efficient gene manipulation in specific cell populations. Cerebellar Purkinje cells play a pivotal role in cerebellar functions.
Keisuke Nitta, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai   +3 more
doaj   +1 more source

Purkinje cell models: past, present and future. [PDF]

Front Comput Neurosci
The investigation of the dynamics of Purkinje cell (PC) activity is crucial to unravel the role of the cerebellum in motor control, learning and cognitive processes. Within the cerebellar cortex (CC), these neurons receive all the incoming sensory and motor information, transform it and generate the entire cerebellar output.
Fernández Santoro EM, Karim A, Warnaar P, De Zeeuw CI, Badura A, Negrello M.   +5 more
europepmc   +6 more sources

AI‐Powered Smart Displays and AR Glasses: Perspectives and Challenges

Advanced Intelligent Systems, EarlyView.
This perspective examines how AI is reshaping smart displays and AR glasses. The latest in image‐quality enhancement, sensor‐integrated display optimization, and physiological sensing in display systems, followed by AI‐assisted AR technologies including waveguide optimization, image compensation, foveated rendering, and multimodal sensing, is discussed.
Luke Benoit, Yizhou Qian, Yi‐Chien Chen, Ziyang Shen, Po‐Sheng Chiu, Youngeon Lee, Cheng‐Han Ke, Chih‐Lung Lin, Shin‐Tson Wu   +8 more
wiley   +1 more source

Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum

Cells
Fetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar weight, and cell death.
MaKenna Y. Cealie, James C. Douglas, Hannah K. Swan, Erik D. Vonkaenel, Matthew N. McCall, Paul D. Drew, Ania K. Majewska   +6 more
doaj   +1 more source

Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells

FASEB BioAdvances, 2020
The brain produces steroids de novo from cholesterol, so‐called “neurosteroids.” The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from cholesterol in
Kazuyoshi Tsutsui, Shogo Haraguchi
doaj   +1 more source

Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan Sulfate Ndst Gene Function

Journal of Developmental Biology, 2020
Disruption of the Heparan sulfate (HS)-biosynthetic gene N-acetylglucosamine N-Deacetylase/N-sulfotransferase 1 (Ndst1) during nervous system development causes malformations that are composites of those caused by mutations of multiple HS binding growth ...
Lars Lewejohann, Srinivas R. Pallerla, Rebecca S. Schreiber, Joanna Gerula, Kay Grobe   +4 more
doaj   +1 more source

Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

eLife, 2021
Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially vulnerable and likely instigate disease by impairing the function ...
Meike E van der Heijden, Elizabeth P Lackey, Ross Perez, Fatma S Ișleyen, Amanda M Brown, Sarah G Donofrio, Tao Lin, Huda Y Zoghbi, Roy V Sillitoe   +8 more
doaj   +1 more source

Dendritic spikes control synaptic plasticity and somatic output in cerebellar Purkinje cells. [PDF]

, 2007
Neurons receive the vast majority of their input onto their dendrites. Dendrites express a plethora of voltage-gated channels. Regenerative, local events in dendrites and their role in the information transformation in single neurons are, however, poorly
Rancz, E.A., Rancz, Ede Attila
core  

Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf, Andrea Accogli, Fadi F. Hamdan, Francesca Nardecchia, Toshiyuki Itai, Kenneth A. Myers, Christine Saint Martin, Myriam Srour   +7 more
wiley   +1 more source