Results 41 to 50 of about 48,590 (271)

Purkinje Cell Conditioned Pause Parameters [PDF]

, 2021
Trial-by-trial analysis of the conditional pause in the spontaneous firing of the Purkinje cell; data from Hesslow ...
Charles Randy Gallistel
core   +4 more sources

Studying cerebellar circuits by remote control of selected neuronal types with GABA-A receptors

Frontiers in Molecular Neuroscience, 2009
Although GABA-A receptor-mediated inhibition of cerebellar Purkinje cells by molecular layer interneurons (MLIs) has been studied intensely on the cellular level, it has remained unclear how this inhibition regulates cerebellum-dependent behaviour.
William Wisden, Andrew J Murray, Christina J McClure, Peer Wulff   +3 more
doaj   +1 more source

Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration

Neurobiology of Disease, 2011
Tuberous sclerosis complex (TSC) is a neurogenetic disorder that often causes brain abnormalities leading to epilepsy, developmental delay, and autism.
R. Michelle Reith, Sharon Way, James McKenna, III, Katherine Haines, Michael J. Gambello   +4 more
doaj   +1 more source

Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration

Neurobiology of Disease, 2011
Alteration in mitochondrial dynamics has been implicated in many neurodegenerative diseases. Mitochondrial apoptosis inducing factor (AIF) plays a key role in multiple cellular and disease processes.
Seung-Hyuk Chung, Marco Calafiore, Jennifer M. Plane, David E. Pleasure, Wenbin Deng   +4 more
doaj   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Microglia promote the death of developing Purkinje cells [PDF]

, 2004
The loss of neuronal cells, a prominent event in the development of the nervous system, involves regulated triggering of programmed cell death, followed by efficient removal of cell corpses.
Colin, C, Marin-Teva, JL, van Rooijen, Nico, van Rooijen, N., Dusart, I, Mallat, M, Rooijen, N. van, Colin, Catherine, Garvais, A, Dusart, Isabelle, Mallat, Michel, Luis Marín-Teva, José, Marı́n-Teva, José Luis, Gervais, Annie   +13 more
core   +1 more source

scTIDE: Deciphering Critical Transitions Through Cell‐Perturbed Manifold Graphs and Optimal Transport Conditional Flow Matching

Advanced Science, EarlyView.
scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong, Bowen Niu, Yongbo Yu, Shiyang Nie, Xuerong Gu, Pei Chen, Rui Liu   +6 more
wiley   +1 more source

Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum

Brain Sciences, 2020
Human cerebellar development occurs late in gestation and is hindered by preterm birth. The fetal development of Purkinje cells, the primary output cells of the cerebellar cortex, is crucial for the structure and function of the cerebellum.
Tara Barron, Jun Hee Kim
doaj   +1 more source

Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells. [PDF]

PLoS ONE, 2014
Nuclear receptors and their coregulators play a critical role in brain development by regulating the spatiotemporal expression of their target genes.
Bum Jun Kim, Daryl A Scott
doaj   +1 more source