Results 71 to 80 of about 5,279,387 (270)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

eLife, 2020
Mutations in KCNC3, which encodes the Kv3.3 K+ channel, cause spinocerebellar ataxia 13 (SCA13). SCA13 exists in distinct forms with onset in infancy or adulthood.
Jui-Yi Hsieh, Brittany N Ulrich, Fadi A Issa, Meng-chin A Lin, Brandon Brown, Diane M Papazian   +5 more
doaj   +1 more source

The ducky^{2J} Mutation in Cacna2d2 Results in Reduced Spontaneous Purkinje Cell Activity and Altered Gene Expression [PDF]

, 2006
The mouse mutant ducky and its allele ducky^{2J} represent a model for absence epilepsy characterized by spike-wave seizures and cerebellar ataxia. These mice have mutations in Cacna2d2, which encodes the α₂δ-2 calcium channel subunit.
Davies, A, Wilkinson, T, Page, KM, Foucault, I, Rees, M, Dolphin, AC, Koch, D, Donato, R, Nieto-Rostro, M, Edwards, FA   +9 more
core  

Cell-Wide DNA De-Methylation and Re-Methylation of Purkinje Neurons in the Developing Cerebellum. [PDF]

, 2016
Global DNA de-methylation is thought to occur only during pre-implantation and gametogenesis in mammals. Scalable, cell-wide de-methylation has not been demonstrated beyond totipotent stages.
Chiao-Ling Lo (401925), Zhou, Feng C., Marisol Resendiz (3094887), Lo, Chiao-Ling, Feng C Zhou, Yuanyuan Chen, Chiao-Ling Lo, Feng C. Zhou (394998), Resendiz, Marisol, Chen, Yuanyuan, Marisol Resendiz, Yuanyuan Chen (165812)   +11 more
core   +2 more sources

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Human aldolase C: gene transcriptional regulation and protein functional role [PDF]

, 2011
Aldolase C is the brain-specific aldolase isoenzyme. In the human brain, aldolase C messenger and protein are expressed in a stripe-like pattern in the Purkinje cells of the cerebellum, in the inferior olives and in the Goll and Burdach nuclei of the ...
Serio, Laura
core   +1 more source

Purkinje cells in eyeblink conditioning: a systematic review of methodological approaches in animal studies

Frontiers in Synaptic Neuroscience
BackgroundEyeblink conditioning is a canonical model of associative motor learning and has played a central role in theories of cerebellar plasticity.
Artem Gornov, Thiago C. Moulin, Thiago C. Moulin, Thiago C. Moulin, Anders Rasmussen, Fredrik Johansson   +5 more
doaj   +1 more source

Mild Cerebellar Neurodegeneration of Aged Heterozygous PCD Mice Increases Cell Fusion of Purkinje and Bone Marrow-Derived Cells

Cell Transplantation, 2012
Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury.
David Díaz, Javier S. Recio, Eduardo Weruaga, Jose R. Alonso   +3 more
doaj   +1 more source

Modulation, plasticity and pathophysiology of the parallel fiber-Purkinje cell synapse

Frontiers in Synaptic Neuroscience, 2016
The parallel fiber-Purkinje cell synapse represents the point of maximal signal divergence in the cerebellar cortex with an estimated number of about 60 billion synaptic contacts in the rat and 100,000 billions in humans.
Eriola Hoxha, Filippo Tempia, Pellegrino Lippiello, Maria Concetta Miniaci   +3 more
doaj   +1 more source

Firing Dynamics of Cerebellar Purkinje Cells [PDF]

Journal of Neurophysiology, 2007
Knowledge of intrinsic neuronal firing dynamics is a critical first step to establishing an accurate biophysical model of any neuron. In this study we examined cerebellar Purkinje cells to determine the bifurcations likely to underlie firing dynamics within a biophysically realistic and experimentally supported model.
Fernando R, Fernandez, Jordan D T, Engbers, Ray W, Turner   +2 more
openaire   +2 more sources