Results 71 to 80 of about 48,590 (271)

The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum. [PDF]

PLoS ONE, 2008
The adult cerebellar cortex is comprised of reproducible arrays of transverse zones and parasagittal stripes of Purkinje cells. Adult stripes are created through the perinatal rostrocaudal dispersion of embryonic Purkinje cell clusters, triggered by ...
Matt Larouche, Uwe Beffert, Joachim Herz, Richard Hawkes   +3 more
doaj   +1 more source

Cardiac morphological and morphometric analysis of Ardea alba

The Anatomical Record, EarlyView.
Abstract Ardea alba (Linnaeus, 1758) is a widely distributed heron species whose cardiovascular morphology remains poorly described. This study aimed to characterize the cardiac morphology and morphometry of adult A. alba. Ten specimens were analyzed using radiographic, morphometric, histological, scanning electron microscopy, and three‐dimensional ...
Julia Vaz Feio, Max Alex Santos Ferreira, Elane Guerreiro Giese, Érika Branco, Antônio Basílio Guerreiro Junior, Ana Rita de Lima   +5 more
wiley   +1 more source

Cell-Wide DNA De-Methylation and Re-Methylation of Purkinje Neurons in the Developing Cerebellum. [PDF]

, 2016
Global DNA de-methylation is thought to occur only during pre-implantation and gametogenesis in mammals. Scalable, cell-wide de-methylation has not been demonstrated beyond totipotent stages.
Chiao-Ling Lo (401925), Zhou, Feng C., Marisol Resendiz (3094887), Lo, Chiao-Ling, Feng C Zhou, Yuanyuan Chen, Chiao-Ling Lo, Feng C. Zhou (394998), Resendiz, Marisol, Chen, Yuanyuan, Marisol Resendiz, Yuanyuan Chen (165812)   +11 more
core   +2 more sources

Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

eLife, 2020
Mutations in KCNC3, which encodes the Kv3.3 K+ channel, cause spinocerebellar ataxia 13 (SCA13). SCA13 exists in distinct forms with onset in infancy or adulthood.
Jui-Yi Hsieh, Brittany N Ulrich, Fadi A Issa, Meng-chin A Lin, Brandon Brown, Diane M Papazian   +5 more
doaj   +1 more source

Purkinje Cells Pathology in Alzheimer’s Disease [PDF]

American Journal of Alzheimer's Disease & Other Dementias®, 2019
Alzheimer’s disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic, limbic,
Ioannis Mavroudis, Foivos Petridis, Dimitrios Kazis, Samuel N. Njau, Vasiliki Costa, Stavros J. Baloyannis   +5 more
openaire   +2 more sources

Clinical Anatomy of the Left and Right Atrial Appendages in Humans: Comparative and Developmental Perspective

Clinical Anatomy, EarlyView.
ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová, Caroline Neradilová, Jan Kovanda, Jan Burkert, Jiří Beneš Jr., Martin Bartos, Theodor Adla, Vojtech Melenovsky, Alena Kvasilova, Ondrej Fabian, Ondrej Naňka, David Sedmera   +11 more
wiley   +1 more source

The ducky^{2J} Mutation in Cacna2d2 Results in Reduced Spontaneous Purkinje Cell Activity and Altered Gene Expression [PDF]

, 2006
The mouse mutant ducky and its allele ducky^{2J} represent a model for absence epilepsy characterized by spike-wave seizures and cerebellar ataxia. These mice have mutations in Cacna2d2, which encodes the α₂δ-2 calcium channel subunit.
Davies, A, Wilkinson, T, Page, KM, Foucault, I, Rees, M, Dolphin, AC, Koch, D, Donato, R, Nieto-Rostro, M, Edwards, FA   +9 more
core  

Deletion of the GluR delta 2 Receptor in the Hotfoot Mouse Mutant Causes Granule Cell Loss, Delayed Purkinje Cell Death, and Reductions in Purkinje Cell Dendritic Tree Area [PDF]

, 2016
International audienceRecent studies have found that in the cerebellum, the delta 2 glutamate receptor (GluR delta 2) plays a key role in regulating the differentiation of parallel fiber-Purkinje synapses and mediating key physiological functions in the ...
Vogel, Michael W., Mariani, Jean, Zanjani, Hadi S.   +2 more
core   +1 more source

Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42

Neurobiology of Disease, 2019
Spinocerebellar ataxia 42 (SCA42) is a neurodegenerative disorder recently shown to be caused by c.5144G > A (p.Arg1715His) mutation in CACNA1G, which encodes the T-type voltage-gated calcium channel CaV3.1. Here, we describe a large Japanese family with
Shunta Hashiguchi, Hiroshi Doi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Shigeru Koyano, Masaki Okubo, Hitaru Kishida, Masaaki Shiina, Kazuhiro Ogata, Fumiko Hirashima, Yukichi Inoue, Shun Kubota, Noriko Hayashi, Haruko Nakamura, Keita Takahashi, Atsuko Katsumoto, Mikiko Tada, Kenichi Tanaka, Toshikuni Sasaoka, Satoko Miyatake, Noriko Miyake, Hirotomo Saitsu, Nozomu Sato, Kokoro Ozaki, Kiyobumi Ohta, Takanori Yokota, Hidehiro Mizusawa, Jun Mitsui, Hiroyuki Ishiura, Jun Yoshimura, Shinichi Morishita, Shoji Tsuji, Hideyuki Takeuchi, Kinya Ishikawa, Naomichi Matsumoto, Taro Ishikawa, Fumiaki Tanaka   +38 more
doaj   +1 more source

Encoding of action by the Purkinje cells of the cerebellum [PDF]

Nature, 2015
Execution of accurate eye movements depends critically on the cerebellum, suggesting that the major output neurons of the cerebellum, Purkinje cells, may predict motion of the eye. However, this encoding of action for rapid eye movements (saccades) has remained unclear: Purkinje cells show little consistent modulation with respect to saccade amplitude ...
David J. Herzfeld, Yoshiko Kojima, Robijanto Soetedjo, Reza Shadmehr   +3 more
openaire   +2 more sources