Results 71 to 80 of about 12,040,588 (301)
Equine models in translational medicine: A comparative approach to human health
Animal Models and Experimental Medicine, EarlyView.This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh +1 more
wiley +1 more source
Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells
FASEB BioAdvances, 2020 The brain produces steroids de novo from cholesterol, so‐called “neurosteroids.” The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from cholesterol in
Kazuyoshi Tsutsui, Shogo Haraguchi
doaj +1 more source
Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan Sulfate Ndst Gene Function
Journal of Developmental Biology, 2020 Disruption of the Heparan sulfate (HS)-biosynthetic gene N-acetylglucosamine N-Deacetylase/N-sulfotransferase 1 (Ndst1) during nervous system development causes malformations that are composites of those caused by mutations of multiple HS binding growth ...
Lars Lewejohann +4 more
doaj +1 more source
Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons
eLife, 2021 Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially vulnerable and likely instigate disease by impairing the function ...
Meike E van der Heijden +8 more
doaj +1 more source
Experimentally-calibrated population of models predicts and explains inter-subject variability in cardiac cellular\ud electrophysiology [PDF]
, 2013 Cellular and ionic causes of variability in the electrophysiological activity of hearts from individuals of the same species are unknown. However, improved understanding of this variability is key to enable prediction of the response of specific hearts ...
Britton, O.J. +6 more
core +1 more source
Journal of Neurology Neurosurgery & Psychiatry, 2014 The spinocerebellar ataxias are a genetically heterogeneous group of disorders with clinically overlapping phenotypes arising from Purkinje cell degeneration, cerebellar atrophy and varying degrees of degeneration of other grey matter regions.
K. Hekman, C. Gomez
semanticscholar +1 more source
Cardiac morphological and morphometric analysis of Ardea alba
The Anatomical Record, EarlyView.Abstract Ardea alba (Linnaeus, 1758) is a widely distributed heron species whose cardiovascular morphology remains poorly described. This study aimed to characterize the cardiac morphology and morphometry of adult A. alba. Ten specimens were analyzed using radiographic, morphometric, histological, scanning electron microscopy, and three‐dimensional ...
Julia Vaz Feio +5 more
wiley +1 more source
CellsFetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar weight, and cell death.
MaKenna Y. Cealie +6 more
doaj +1 more source
The Marr and Albus Theories of the Cerebellum: Two Eary Models of Associative Memory [PDF]
, 1989 The Marr and Albus theories of the cerebellum are compared and contrasted. They are shown to be similar in their analysis of the function of the mossy fibers, granule cells, Golgi cells, and Purkinje cells.
Albus, James S.
core +1 more source
Developmental Dynamics, EarlyView.Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee +6 more
wiley +1 more source