Results 81 to 90 of about 12,040,588 (301)

Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells

iScience, 2022
Summary: Currently, there are no treatments that ameliorate cardiac cell death, the underlying basis of cardiovascular disease. An unexplored cell type in cardiac regeneration is cardiac Purkinje cells; specialized cells from the cardiac conduction ...
Nicole Prodan, Faheem Ershad, Arfaxad Reyes-Alcaraz, Luge Li, Brandon Mistretta, Lei Gonzalez, Zhoulyu Rao, Cunjiang Yu, Preethi H. Gunaratne, Na Li, Robert J. Schwartz, Bradley K. McConnell   +11 more
doaj   +1 more source

Proceedings of Abstracts Engineering and Computer Science Research Conference 2019 [PDF]

, 2019
© 2019 The Author(s). This is an open-access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Adams, Roderick, Amafabia, Daerefa-a, Barker, Trevor, Beka, Nathan, Bhavsar, Ronakben, Bonivart, Agnes, Canoville, Paul, Cañamero, Lola, CHEN, Yong Kang, CHEN, Yong Kang, Chrysanthou, Andreas, Counsell, Nathan, Crook, Brian, Davey, Neil, David-West, Opukuro, Denai, Mouloud, Dhakal, Hom, Drix, Damien, Goncharenko, Julia, Grasso, Marzio, Hafner, Verena Vanessa, Hall, Samantha, Haritos, George, Hassan, Eheda, Helian, Na, Herfatmanesh, Mohammad Reza, Ismail, Sikiru O., Johnston, Ian, Johnston, Ian, Kadir, Shabnam, Kaye, Richard, Khan, Imran, Kirner, Raimund, Kirner, Raimund, Klaholz, Ingo, Klusak, Jan, Kourtessis, Pandelis, Lane, Peter, Lekkala, Himayasri Rao, Lilley, Mariana, Mayor, David, McCluskey, Daniel, McCluskey, Daniel, Menon, Catherine, Metzner, Christoph, Miko, Rebecca, Montalvão, Diogo, Mporas, Iosif, Munro, Ian, Nehaniv, Chrystopher, Newman, James, Nwawe, Richard, Panday, Deepak, Partou, Helen, Pissanidis, Georgios, Polani, Daniel, Ren, Guogang, Robinson, Matthew, Rosiello, Vincenzo, Sayers, Paul, Schilstra, Maria, Schirmer, Pascal, Schmuker, Michael, Siadati, Rana, Sinha, Ankur, Skaltsas, Grigorios, Steffert, Tony, Steuber, Volker, Steuber, Volker, Suckow, Bjorn, Sun, Yi, Sun, Yichuang, Sunmola, Funlade, Sutton, Samuel, te Boekhorst, Rene, Toffe, Gilles, Tracey, Mark, Tveretina, Olga, Veneziano, Vito, Verma, Alok, Wang, Yuan, Wernick, Paul   +81 more
core   +2 more sources

Precise Control of Movement Kinematics by Optogenetic Inhibition of Purkinje Cell Activity

Journal of Neuroscience, 2014
Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking. We used an optogenetic approach in
Shane A. Heiney, Jinsook Kim, G. Augustine, J. Medina   +3 more
semanticscholar   +1 more source

Firing Dynamics of Cerebellar Purkinje Cells [PDF]

Journal of Neurophysiology, 2007
Knowledge of intrinsic neuronal firing dynamics is a critical first step to establishing an accurate biophysical model of any neuron. In this study we examined cerebellar Purkinje cells to determine the bifurcations likely to underlie firing dynamics within a biophysically realistic and experimentally supported model.
Fernando R, Fernandez, Jordan D T, Engbers, Ray W, Turner   +2 more
openaire   +2 more sources

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42

Neurobiology of Disease, 2019
Spinocerebellar ataxia 42 (SCA42) is a neurodegenerative disorder recently shown to be caused by c.5144G > A (p.Arg1715His) mutation in CACNA1G, which encodes the T-type voltage-gated calcium channel CaV3.1. Here, we describe a large Japanese family with
Shunta Hashiguchi, Hiroshi Doi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Shigeru Koyano, Masaki Okubo, Hitaru Kishida, Masaaki Shiina, Kazuhiro Ogata, Fumiko Hirashima, Yukichi Inoue, Shun Kubota, Noriko Hayashi, Haruko Nakamura, Keita Takahashi, Atsuko Katsumoto, Mikiko Tada, Kenichi Tanaka, Toshikuni Sasaoka, Satoko Miyatake, Noriko Miyake, Hirotomo Saitsu, Nozomu Sato, Kokoro Ozaki, Kiyobumi Ohta, Takanori Yokota, Hidehiro Mizusawa, Jun Mitsui, Hiroyuki Ishiura, Jun Yoshimura, Shinichi Morishita, Shoji Tsuji, Hideyuki Takeuchi, Kinya Ishikawa, Naomichi Matsumoto, Taro Ishikawa, Fumiaki Tanaka   +38 more
doaj   +1 more source

Effect of intrauterine morphine sulfate exposure on cerebellar histomorphological changes in neonatal mice [PDF]

, 2011
Neurotoxic effects of morphine sulfate in adult cerebellar cortex and neonatal cerebral cortex have been studied in animal models. This study was done to determine the neurotoxic effects of prenatal morphine exposure on the histo morphological changes of
Ghafari, S., Golalipour, M.J., Roshandel, D.   +2 more
core  

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

eLife, 2020
Mutations in KCNC3, which encodes the Kv3.3 K+ channel, cause spinocerebellar ataxia 13 (SCA13). SCA13 exists in distinct forms with onset in infancy or adulthood.
Jui-Yi Hsieh, Brittany N Ulrich, Fadi A Issa, Meng-chin A Lin, Brandon Brown, Diane M Papazian   +5 more
doaj   +1 more source

The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum. [PDF]

PLoS ONE, 2008
The adult cerebellar cortex is comprised of reproducible arrays of transverse zones and parasagittal stripes of Purkinje cells. Adult stripes are created through the perinatal rostrocaudal dispersion of embryonic Purkinje cell clusters, triggered by ...
Matt Larouche, Uwe Beffert, Joachim Herz, Richard Hawkes   +3 more
doaj   +1 more source