Results 101 to 110 of about 5,279,387 (270)
Transient developmental Purkinje cell axonal torpedoes in healthy and ataxic mouse cerebellum
Frontiers in Cellular Neuroscience, 2016 Information is carried out of the cerebellar cortical microcircuit via action potentials propagated along Purkinje cell axons. In several human neurodegenerative diseases, focal axonal swellings on Purkinje cells – known as torpedoes – have been ...
Lovisa Ljungberg +5 more
doaj +1 more source
The FEBS Journal, EarlyView.As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley +1 more source
Altered dendritic morphology of Purkinje cells in Dyt1 ΔGAG knock-in and purkinje cell-specific Dyt1 conditional knockout mice. [PDF]
, 2011 DYT1 early-onset generalized dystonia is a neurological movement disorder characterized by involuntary muscle contractions. It is caused by a trinucleotide deletion of a GAG (ΔGAG) in the DYT1 (TOR1A) gene encoding torsinA; the mouse homolog of this gene
David G Standaert +15 more
core +1 more source
Safety of Pulsed Field Ablation: Established Evidence, Emerging Risks, and Knowledge Gaps
Pacing and Clinical Electrophysiology, EarlyView.Overview of the safety profile of pulsed field ablation (PFA), highlighting established safety advantages, procedure‐related complications, electroporation‐specific effects, and key areas of ongoing uncertainty, particularly for ventricular applications.
Dakota de Cecco +3 more
wiley +1 more source
Cerebrovascular regulation during heat stress
Experimental Physiology, EarlyView.Abstract Given that the brain is a highly metabolic organ and is enclosed by the skull, effective regulation of cerebral blood flow (CBF), not only for oxygen and nutrients supply but also as a means of convective heat exchange, is critical for preventing excessive elevations in brain temperature.
Kanoko Ito, Manabu Shibasaki
wiley +1 more source
Biosynthesis, mode of action and functional significance of neurosteroids in the Purkinje cell
Frontiers in Endocrinology, 2011 The brain has traditionally been considered to be a target site of peripheral steroid hormones. In addition to this classical concept, we now know that the brain has the capacity to synthesize steroids de novo from cholesterol, the so-called ...
Kazuyoshi eTsutsui +4 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source