Results 121 to 130 of about 5,279,387 (270)

GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function

, 2017
Summary: During embryonic development of the cerebellum, Purkinje cells (PCs) migrate away from the ventricular zone to form the PC plate. The mechanisms that regulate PC migration are incompletely understood.
Carlos F. Ibáñez, Sergaki, MC, Maria Christina Sergaki, Ibáñez, CF   +3 more
core   +1 more source

The ultrarapid delayed rectifier potassium current has important functional role in the repolarization reserve of canine and human ventricular muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial‐specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we challenged this prevailing concept and investigated the potential role of IKur in ventricular ...
Alaa Amin E. Abdelmagid, Aiman Saleh A. Mohammed, Gábor Mohácsi, Benjámin Paskuj, Gergő Bitay, Jakub Tomek, Sahil Dalal, Tamás Árpádffy‐Lovas, Vivien Demeter‐Haludka, István Koncz, Muhammad Naveed, László Virág, Norbert Nagy, András Varró, István Baczkó, Norbert Jost, Zsófia Kohajda, Leila Topal   +17 more
wiley   +1 more source

Electrophysiological properties of mesodiencephalic junction neurons projecting to the inferior olive

The Journal of Physiology, EarlyView.
Abstract figure legend Highlights of the main electrophysiological differences between MDJ neurons that project to the IO and those that do not. IO‐projecting neurons fire rebound spikes and are spontaneously active at higher frequencies. The bottom panel shows the anatomical connectivity of the MDJ with both excitatory and newly discovered inhibitory ...
Stijn Voerman, Xiang Wang, Xiaolu Wang, Laurens W. J. Bosman, Robin Broersen, Chris I. De Zeeuw   +5 more
wiley   +1 more source

Dyssynchrony without dysfunction: Left bundle branch block does not acutely reduce cardiac output

The Journal of Physiology, EarlyView.
Abstract figure legend Six electromechanical in silico heart models were simulated under healthy and pure acute left bundle branch block (LBBB) conditions. LBBB induced electrical dyssynchrony and increased left ventricular free wall strain, while the right and left ventricular ejection fraction remained relatively unchanged.
Carola Kruthoff, Jonathan Krauß, Jorge Sánchez, Tobias Gerach, Cristian Barrios Espinosa, Jan‐Erik Duhme, Axel Loewe   +6 more
wiley   +1 more source

Multi‐Organ Inflammatory and Endocrine Crosstalk Shapes the Early Brain Response to Combined Burn and Blast Injury

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Concomitant burn injury and blast‐induced mild TBI lead to a magnified neuroimmune response shaped by endocrine stress‐related pathways and IL‐1R1‐dependent inflammatory signals, which also produce cytokine‐mediated impairment of erythropoiesis. These integrated systemic and CNS responses illustrate how inflammation, hematopoietic adaptation, and early
Hana C. Schwierling, Satarupa Sengupta, John G. Noel, Christopher J. O'Connell, Andrew S. Potter, Mike Adam, Matthew J. Robson, Jason C. Gardner   +7 more
wiley   +1 more source

SYNAPSES ON THE PURKINJE CELLS OF THE FROG [PDF]

Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1958
P, GLEES, C, PEARSON, A G, SMITH
openaire   +2 more sources

Comparison of Purkinje cell cytotoxicity produced by anti-Yo antibodies with cytotoxicity produced by commercial and patient antibodies reactive with other Purkinje cell cytoplasmic proteins.

, 2015
Rat cerebellar slice cultures were incubated for 72 hours with either 1) sera from patients with anti-Yo antibodies; 2) commercial antibodies to calbindin, calmodulin, or PCP-2/L7; 3) anti-Purkinje cells antibodies from the three neurologically normal ...
Kenneth E. Hill (725581), Ikuo Tsunoda (725584), Susan A. Clawson (725580), Blair Wood (725582), Noel G. Carlson (725585), Stacey L. Clardy (725583), John E. Greenlee (725579)   +6 more
core   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, Volume 100, Issue 5, Page 915-930, November 2026.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

Analysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi, Jacob T. Theismann, Michael A. Johnson   +2 more
wiley   +1 more source

Modulation, plasticity, and pathophysiology of the cerebellar parallel fiber-Purkinje cell synapse [PDF]

, 2016
An overview of the modulation, plasticity, and pathophysiology of the cerebellar parallel fiber-Purkinje cell ...
MINIACI, MARIA
core