Results 131 to 140 of about 5,279,387 (270)

Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant

, 2003
Heterokaryons are the product of cell fusion without subsequent nuclear or chromosome loss. Decades of research using Sendai-virus or polyethylene glycol (PEG)-mediated fusion in tissue culture showed that the terminally differentiated state of a cell ...
James M. Weimann, Clas B. Johansson, Helen M. Blau, Johansson, CB, Trejo, A, Angelica Trejo, Weimann, JM, Blau, HM   +7 more
core   +1 more source

Intrinsic Activity Reductions and Cerebello‐Cortical Diaschisis‐Like Mechanism in Friedreich Ataxia: An fALFF Resting‐State fMRI Study

Brain and Behavior, Volume 16, Issue 11, November 2026.
Abstract Background Friedreich ataxia (FA) is characterized by progressive degeneration of the cerebellum and its output pathways, particularly the dentato–thalamo–cortical system, leading to motor impairment and the cerebellar cognitive affective syndrome (CCAS).
Naeije Gilles, Trotta Nicola, Rovai Antonin   +2 more
wiley   +1 more source

Toward Cell‐Specific Molecular MRI: Modulating Chemical Exchange Saturation Transfer Contrast With Manganese

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
Manganese‐modulated chemical exchange saturation transfer (CEST) MRI, Manga CEST, leverages intracellular Mn2+ uptake to selectively perturb CEST contrast. Comparing Z‐spectra before and after Mn reveals compartment‐specific contributions. In vivo, neuron‐enriched Mn accumulation induces frequency‐dependent attenuation (3–4 ppm), enabling cell‐weighted
Eleonora Cavallari, Valeria Bitonto, Morgana Giachello, Angelo Bifone   +3 more
wiley   +2 more sources

Possible Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS) Presenting in Late Adolescence and Early Adulthood: A Case Series

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT PANDAS‐like syndromes may rarely occur beyond childhood. Although these patients may meet criteria for PANS, recognizing a possible streptococcal‐triggered subgroup remains important for diagnosis, future biomarker discovery, and refinement of disease classification.
Tariq A. Madani, Fahd S. Alsallum, Ola H. Abudaowd, Salman T. Madani   +3 more
wiley   +1 more source

Müller Glia Subtypes Define Neuro‐Glial Associations and Spatial Morphogen Axes in the Zebrafish Retina

Glia, Volume 74, Issue 11, November 2026.
Zebrafish Müller glia are heterogeneous in the early larval retina. Zebrafish Müller glia subtypes define a spatial axis of retinoic acid metabolism. Neuron‐associated glial programs identified in Zebrafish Müller glia are evolutionarily conserved in mammals. ABSTRACT Müller glia are instrumental macroglia of the vertebrate retina, once thought to be a
Samuel S. Storey, Carrie L. Hehr, Shaelene Standing, Sarah McFarlane   +3 more
wiley   +1 more source

Development of adenosine signalling in the cerebellum [PDF]

The release and clearance of adenosine are reasonably well-documented in the mature CNS but relatively little is known about how adenosine signalling changes during postnatal development.
Atterbury, Alison
core  

Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia

MedComm, Volume 7, Issue 11, November 2026.
Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song, Li‐Rong Zhang, Yun‐Mei Wang, Yan Hu, Qing Li, Ren‐Rong Tian, Liu‐Meng Yang, Si‐Dong Xiong, Dong‐Dong Wu, Yong‐Tang Zheng   +9 more
wiley   +1 more source

Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation

, 1993
Thyroid hormones play an important role in brain development, but the mechanism(s) by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood. Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3 (NT-3),
H Thoenen, Lindholm, D, Parada, L F, Kolbeck, R, Heisenberg, C P, A Leingärtner, D Lindholm, R Kolbeck, M da P Berzaghi, Berzaghi, M da P, Tessarollo, L, CP Heisenberg, Tsoulfas, P, Thoenen, H, Leingärtner, A, L Tesarollo, L Tessarollo, Castrén, E, E Castrén, LF Parada, P Tsoulfas, Tesarollo, L   +21 more
core   +1 more source

Pitfalls in diagnosing and long‐term management of ceroid lipofuscinosis NCL4A in a mixed‐breed dog

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract An 8‐year‐old, spayed, female, mixed‐breed dog was presented with a 9‐month history of occasionally stumbling on walks, having difficulty navigating stairs and jumping into the car. A prior computed tomography scan of the head revealed mild leptomeningeal enhancement and suggested meningoencephalitis.
Ingeborg Hein, Ines Heinreich, Florian Willmitzer, Marion Mucha   +3 more
wiley   +1 more source

Purkinje cell models

Frontiers in Computational Neuroscience
The investigation of the dynamics of Purkinje cell (PC) activity is crucial to unravel the role of the cerebellum in motor control, learning and cognitive processes. Within the cerebellar cortex (CC), these neurons receive all the incoming sensory and motor information, transform it and generate the entire cerebellar output.
Fernández Santoro, Elías Mateo, Karim, Arun, Warnaar, Pascal, De Zeeuw, Chris I., Badura, Aleksandra, Negrello, Mario   +5 more
openaire   +1 more source