Results 151 to 160 of about 5,279,387 (270)

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction. [PDF]

Brain
Ibrahim MF, Boyanova S, Cheng YC, Ligneul C, Bains RS, Johnpulle TC, Lerch JP, Mann EO, Oliver PL, Becker EBE.   +9 more
europepmc   +2 more sources

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1964-1981, October 2026.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Purkinje cell arrival at the Purkinje cell layer orchestrates cerebellar foliation and its temporal sequence. [PDF]

iScience
Uchi R, Honda T, Kasai T, Hirota Y, Nakajima K.   +4 more
europepmc   +1 more source

Purkinje cell intrinsic activity shapes cerebellar development and function. [PDF]

Nat Commun
Osório C, White JJ, Torrents-Solé P, Yang J, Mandemaker N, Olivero F, Kirwan F, Post L, Hemmat Z, de Winter F, Regolo E, Fiocchi FR, Serra I, Tjon S, Ozgur Z, van den Hout MCGN, van IJcken WFJ, López-Bendito G, Badura A, Lim L, van Woerden GM, Schonewille M.   +21 more
europepmc   +2 more sources

Roles of Molecular Layer Interneurons in Shaping Purkinje Cell Output

, 2011
The cerebellum is an ideal structure to understand how nervous systems process information. Sensory and cortical information to the cerebellum come through mossy fibers and are relayed through granule cells.
Park, Sung-Min
core  

Gephyrin Neurological Autoimmunity

Annals of Neurology, Volume 100, Issue 4, Page 781-787, October 2026.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

Annals of Neurology, Volume 100, Issue 4, Page 850-866, October 2026.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto, Michael Bonomo, Brianna S. Nelthrope, Benjamin D. Carr, Emma Palmer, Mariana Sierra, Ilkim Erturk, David Peppercorn, Eleonor Cox, Tiare K. Vasconcellos, Henry L. Paulson, Hannah K. Shorrock, Sharan R. Srinivasan   +12 more
wiley   +1 more source

Modulation of mGluR1 signaling improves Purkinje cell dysfunction associated with spinocerebellar ataxia 14. [PDF]

iScience
Sziber Z, Tang S, Torrents-Solé P, Kovacevic A, Kapfhammer JP.   +4 more
europepmc   +1 more source