Results 151 to 160 of about 48,590 (271)
A model of intracellular signalling can implement Radial Basis Function learning in cerebellar Purkinje cells [PDF]
, 2008 It has been suggested that information in the brain is encoded in temporal spike patterns which are decoded by `Radial Basis Function' (RBF) neurons using time delays and coincidence detection.
Volker Steuber +2 more
core
In this note, the author provides a surprising path to potentially validating the ephaptic coupling model presented in the author’s doctoral dissertation and showing its predictive potential.
openaire +2 more sources
Journal of Comparative Neurology, Volume 534, Issue 7, July 2026.1. We investigated two skink species differing primarily in social ecology. 2. Using immunohistochemistry, we investigated the distribution of four neurotransmitters known to play a role in vertebrate social behavior. 3. We generally found these transmitters in more brain regions in the family‐living species.
Jai Lake +5 more
wiley +1 more source
Mesenchymal Stem Cell‐Based Therapy for Cerebellar Ataxia: From Bench to Bedside
CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.Allogeneic hMSCs transplanted across LPS, Ara‐C, and SCA2 cerebellar ataxia (CA) models suppress neuroinflammation and restore the neurotrophin axis, collectively preserving Purkinje cell integrity. These preclinical findings are being translated clinically, from a first‐in‐human case report to an ongoing Phase II/III randomized trial (NCT02540655 ...
Kyoungho Suk +2 more
wiley +1 more source
Frontiers in Computational NeuroscienceThe investigation of the dynamics of Purkinje cell (PC) activity is crucial to unravel the role of the cerebellum in motor control, learning and cognitive processes. Within the cerebellar cortex (CC), these neurons receive all the incoming sensory and motor information, transform it and generate the entire cerebellar output.
Fernández Santoro, Elías Mateo +5 more
openaire +1 more source
Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management
MedComm, Volume 7, Issue 7, July 2026.Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu +8 more
wiley +1 more source
Hyaluronan (HA) Receptors: Discovery, Function & Pathology
Proteoglycan Research, Volume 4, Issue 3, July 2026.ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp +8 more
wiley +1 more source
Experience-dependent Selection of Purkinje Cell Targets [PDF]
Senior Honors Thesis, Department of Integrative Biology, University of Wisconsin-MadisonNeuroplasticity refers to the formation of new neuronal connections and the reorganization of existing ones based on experiences and environmental demands.
Jain, Sania
core
British Journal of Pharmacology, Volume 183, Issue 13, Page 3685-3705, July 2026.Abstract Background and Purpose Between‐cell differences in ventricular cardiomyocyte action potential duration (APD) and responses to ion channel block may contribute to pro‐arrhythmic dispersion of myocardial repolarisation. This study quantifies between‐cell physiological and pharmacological variability in the rabbit left ventricle (LV) and uses ...
Rebecca J. Gilchrist +5 more
wiley +1 more source