Results 161 to 170 of about 12,040,588 (301)

Structural Characterization of Cardiac Free‐Running Purkinje Fibers Using Inhomogeneous Magnetization Transfer (ihMT): A Proof of Concept MRI‐Histology Approach

NMR in Biomedicine, Volume 39, Issue 6, June 2026.
The cardiac Purkinje network is essential for synchronized ventricular activation but remains difficult to visualize with conventional MRI due to limited structural contrast. This study demonstrates that inhomogeneous magnetization transfer imaging provides enhanced contrast that differentiates free‐running Purkinje fibers, Purkinje‐Myocardial Junction,
Arash Forodighasemabadi, Evgenios N. Kornaropoulos, Marion Constantin, Lucas Soustelle, Fanny Vaillant, Jude Leury, Richard Walton, Olivier Bernus, Bruno Quesson, Olivier M. Girard, Guillaume Duhamel, Julie Magat   +11 more
wiley   +1 more source

Purkinje cell intrinsic activity shapes cerebellar development and function. [PDF]

Nat Commun
Osório C, White JJ, Torrents-Solé P, Yang J, Mandemaker N, Olivero F, Kirwan F, Post L, Hemmat Z, de Winter F, Regolo E, Fiocchi FR, Serra I, Tjon S, Ozgur Z, van den Hout MCGN, van IJcken WFJ, López-Bendito G, Badura A, Lim L, van Woerden GM, Schonewille M.   +21 more
europepmc   +2 more sources

Combination Versus Monotherapy in Acute Anti‐LGI1 Encephalitis: A Real‐World Dose Optimization Analysis

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Combined IVIg and 500 mg/day IVMP achieve superior efficacy over monotherapies in anti‐LGI1 encephalitis, with optimal safety. Higher‐dose IVMP (1000 mg) accelerates response but increases adverse events, particularly in diabetic patients. Cognitive deficits persist post‐treatment, necessitating long‐term management.
Yao Tan, Ming Sun, Qinqin Liu, Beibei Huang, Chao Wu, Jie Lu, Donglin Zhu   +6 more
wiley   +1 more source

Transcranial Calcium Macro‐Imaging From the Auditory Cortex of Thy1‐Cre‐Driven GCaMP8 Transgenic Rats

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We generated Thy1‐Cre–driven GCaMP8 transgenic rats by mating Thy1‐Cre rats with knock‐in rats carrying a floxed GCaMP8‐STOP cassette in the β‐actin locus. Robust neuronal GCaMP8 expression enabled transcranial calcium imaging of the auditory cortex, establishing this model as a powerful tool for minimally invasive cortical macro‐imaging and functional
Manavu Tohmi, Hisaaki Namba, Meiko Kawamura, Ryuichi Hishida, Shota Iguchi, Kazuto Kobayashi, Natsuki Matsushita, Tomoji Mashimo, Rie Natsume, Kenji Sakimura, Hiroyuki Nawa   +10 more
wiley   +1 more source

In vivo analysis of Purkinje cell firing properties during postnatal mouse development.

Journal of Neurophysiology, 2015
M. Arancillo, Joshua J. White, Tao Lin, Trace L. Stay, R. Sillitoe   +4 more
semanticscholar   +1 more source

Dystrophinopathy with a DMD exon 49–50 deletion in a female patient who developed schizophrenia: An autopsy case

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Mutations in DMD affect not only muscles but also the brain. Cases of schizophrenia with DMD mutations have been described previously. Although female dystrophinopathy often has a milder phenotype, some affected females also have intellectual disabilities and psychiatric disorders.
Shusei Arafuka, Youta Torii, Ayako Miwa, Itaru Kushima, Hirotaka Sekiguchi, Hiroshige Fujishiro, Chikako Habuchi, Hiroaki Miyahara, Yosuke Kawai, Ran Wei, Katsushi Tokunaga, Norio Ozaki, Mari Yoshida, Shuji Iritani, Yasushi Iwasaki, Masashi Ikeda   +15 more
wiley   +1 more source

DENs of Purkinje Cells

In this note, the author provides a surprising path to potentially validating the ephaptic coupling model presented in the author’s doctoral dissertation and showing its predictive potential.
openaire   +2 more sources

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency.

Brain : a journal of neurology, 2015
Dewei Jiang, Ying Zhang, R. Hart, Jianmin Chen, K. Herrup, Jiali Li   +5 more
semanticscholar   +1 more source

Uncertainty should be the rule, not the exception: Integrating fibre orientation variability in cardiac electrophysiology modelling

The Journal of Physiology, EarlyView.
Ovais Ahmed Jaffery, Caroline Helen Roney   +1 more
wiley   +1 more source