Results 161 to 170 of about 5,279,387 (270)

Inhibition of Cerebellar Dentate Nucleus‐Zona Incerta Glutamatergic Circuit Improves Sleep Disturbances in Chronic Temporal Lobe Epilepsy Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Mice with TLE exhibit significant sleep fragmentation and reduced sleep duration, particularly during non‐rapid eye movement sleep. By employing optogenetic and chemogenetic methods to target CDN glutamatergic neurons, we observed a decrease in sleep fragmentation, an increase in overall sleep duration, and an enhancement in sleep quality among TLE ...
Liang Xia, Xuan Wang, Yingchi Zhang, Jianmin Hao, Dan Mi, Changgeng Song, Wen Jiang   +6 more
wiley   +1 more source

Behavioral correlates of Purkinje cell ensemble covariance. [PDF]

Nat Commun
Nashef A, Spindle MS, Calame DJ, Person AL.   +3 more
europepmc   +1 more source

Frequency of anti‐neural antibodies and autoimmune epilepsy in focal epilepsy of unknown etiology: An observational study in a Singaporean cohort

Epilepsia Open, Volume 11, Issue 5, Page 1677-1691, October 2026.
Abstract Objective Autoimmune epilepsy (AES) is increasingly recognized as a condition in patients with epilepsy of unknown etiology. Early immunotherapy improves outcomes; however, data on its prevalence and the frequency of anti‐neural/neuronal antibodies in Asian populations remain scarce.
Seong Jin Park, Jeanne May May Tan, Xuejuan Peng, Patricia Yut Wan Wong, Karine Su Shan Tay, Angelia Swee Hoon Koe, Janis Siew Noi Tye, Josiah Yui Huei Chai, Pei Xuan Koh, Yee Leng Tan, Sheila Srinivasan, Ngai Kun Loh, Nigel Choon Kiat Tan, Kevin Tan, Tianrong Yeo   +14 more
wiley   +1 more source

A Streamlined Workflow for Purkinje Cell Labeling and High-Resolution Analyses of Dendrites and Spines in Mice. [PDF]

eNeuro
Tan X, Niu S, Bai M, Megagiannis P, Suresh R, Pilianidis E, Niibori Y, Hampson DR, Durcan TM, Zhou Y.   +9 more
europepmc   +1 more source

Astrocyte‐enriched and cilia‐related genetic signatures in dementia: A whole‐exome sequencing study

General Psychiatry, Volume 39, Issue 5, October 2026.
ABSTRACT Background Alzheimer's disease (AD), the most prevalent form of dementia, is highly heritable, yet much of its genetic basis remains unexplained. Most genetic studies have focused on European populations, with limited data from under‐represented groups.
Miaohan Deng, Yucan Chen, Lu Zhao, Weichen Song, Qi Qiu, Lin Sun, Xiang Lin, Weidi Wang, Guan Ning Lin, Xia Li   +9 more
wiley   +1 more source

Purkinje cell development and degeneration in the spastic Han-Wistar rat model of ataxia. [PDF]

Sci Rep
Bellafard H, Pelayo T, Aghopoo M, Sarhangnejad D, Gaft S, Radionov G, Hosseini Y, Zuccherato LW, Amorim CEG, de Bellard ME.   +9 more
europepmc   +1 more source

MRI Characterization of Structural Brain Abnormalities in NGLY1 Deficiency

International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.
Structural MRI from 11 patients with NGLY1 deficiency, an ultrarare neurodevelopmental disorder, revealed reduced subcortical volume (thalamus and putamen) across ages and reduced cortical surface area in younger patients. These measures tracked with clinical features such as seizures and gait disturbance, supporting brain imaging as a candidate ...
Emily L. Dennis, Lei Zhu, William F. Mueller, Jennifer W. Cook, Gracie Morrison, Matt Wilsey, Ryan Dant, Selina Dwight, Kevin J. Lee   +8 more
wiley   +1 more source

Cardiac Resynchronization as an Enabler of ARNI Efficacy: Insights From a Real‐World Cohort

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
CRT provides the mechanical substrate that enables sacubitril/valsartan to maximize reverse remodeling. In this real‐world cohort, ARNI therapy was associated with greater improvement in left ventricular function and fewer clinically validated device‐detected HF events, particularly among CRT responders, supporting a synergistic interaction between ...
Amato Santoro, Laura Spaccaterra, Maurizio Collantoni, Claudia Baiocchi, Benedetta Maria Natali, Stefano Lunghetti, Antonio Pagliaro, Niccolò Manetti, Francesco Morrone, Massimo Fineschi, Alberto Palazzuoli   +10 more
wiley   +1 more source

A model of free sialic acid storage disorder reveals hypomyelinating leukodystrophy and Purkinje cell degeneration. [PDF]

Dis Model Mech
Hackbarth ME, Hossain MS, Sabir MS, Leoyklang P, Dorward H, Burke JD, Elliot G, Garrett L, Zerfas P, Springer DA, Pollard L, Wincovitch S, Huizing M, Gahl WA, Malicdan MCV.   +14 more
europepmc   +1 more source

Conduction System Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
Current randomized evidence does not demonstrate statistically significant superiority of CSP over BVP for CRT. Exploratory analyses suggest benefit may be greatest among patients with true LBBB receiving dedicated LBBAP/LBBP. ABSTRACT Background Conduction system pacing (CSP) is an emerging alternative to biventricular pacing (BVP) for cardiac ...
Shreyas Singireddy, Sami Shoura, Darshine Venugopal, Ragavendar Saravanabavanandan, Kyle Coombes, Timir Baman, Siddharth Shah   +6 more
wiley   +1 more source