Results 161 to 170 of about 48,590 (271)

In Silico Drug Repositioning Identifies SYK Kinase Inhibitors as Potential Neuroprotective Agents for Ataxia–Telangiectasia

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Repositioning of vemurafenib and palbociclib as spleen tyrosine kinase inhibitors for the treatment of neuroinflammation in Ataxia–Telangiectasia. ABSTRACT Ataxia–Telangiectasia (AT) is a rare neurodegenerative disorder characterized by progressive neuronal loss and chronic neuroinflammation.
Alessia Romano, Rocco Buccheri, Chiara Zagni, Antonio Rescifina   +3 more
wiley   +1 more source

Cognitive and neurodevelopmental disorders in spinal muscular atrophy type I at the time of disease‐modifying therapies

Developmental Medicine &Child Neurology, Volume 68, Issue 7, Page 909-915, July 2026.
Abstract After treatment with new disease‐modifying therapies, cognitive and neurodevelopmental aspects have been observed in individuals with spinal muscular atrophy (SMA). Emerging evidence suggests that children with SMA type 1 may experience cognitive, language, and behavioural delays, with reported rates of neurodevelopmental difficulties ranging ...
Giorgia Coratti, Bianca Buchignani, Eugenio Mercuri   +2 more
wiley   +1 more source

Steady-state Purkinje cell activity has limited predictive power for cerebellar output in disease. [PDF]

J Physiol
Lyon AM, Hernandez-Castanon V, van der Heijden ME.   +2 more
europepmc   +1 more source

A Novel RORA Hinge‐Region Variant in Adult IDDECA With Cerebellar Atrophy and Marked Response to Valproate

European Journal of Neurology, Volume 33, Issue 7, July 2026.
ABSTRACT Objectives To expand the RORA mutational and clinical spectrum by reporting a novel hinge‐region variant associated with an adult progressive phenotype and a marked therapeutic response to valproate. Methods We describe a 61‐year‐old woman with lifelong intellectual disability who developed subacute severe motor deterioration in adulthood ...
V. Busco, G. Di Lazzaro, A. T. Cimmino, F. Bove, L. Saccinto, G. Silvestri, A. R. Bentivoglio   +6 more
wiley   +1 more source

Climbing fibres recruit disinhibition to enhance Purkinje cell calcium signals. [PDF]

Nature
Santos-Valencia F, Lackey EP, Norton A, Wardak A, Gaynor CS, Ediger S, Hemelt ME, Nguyen TM, Lee WA, Brunel N, Hull CA, Regehr WG.   +11 more
europepmc   +1 more source

Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells

The FEBS Journal, Volume 293, Issue 14, Page 4358-4373, July 2026.
D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono, Yuji Shishido, Toshiyuki Yamagishi, Kiyoshi Fukui   +3 more
wiley   +1 more source

Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1. [PDF]

J Clin Invest
Lee C, Grijalva RM, Tejwani L, Bae E, Chase A, Ro H, Kim H, Olmos V, Orengo JP, Lim J.   +9 more
europepmc   +1 more source

Splice Type‐Specific Effects of Gαo Subunits on Cerebellar Anatomy and Synapse Formation

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Heterotrimeric Go alpha subunits are widely expressed in the brain to act as molecular switches. In this study we show that Gαo1 and Gαo2 affect cerebellar morphology and synapse formation in an opposite manner. While knockout of Gαo1 results in cerebellar hypoplasia and reduced synaptic input to Purkinje cells by VGLUT2‐positive brainstem climbing ...
Markus Höltje, Anton Wolkowicz, Gudrun Ahnert‐Hilger   +2 more
wiley   +1 more source

Pregabalin Depresses Cerebellar Parallel Fiber-Purkinje Cell Synaptic Transmission by Modulating Glun2a-Containing Nmda Receptors in Mice In Vitro. [PDF]

Int J Mol Sci
Li MR, Zhang XD, Chen L, Zhang YD, Wang CY, Zhao ZY, Zhou M, Chu CP, Qiu DL.   +8 more
europepmc   +1 more source

Regeneration of the lizard heart after cryoinjury

Experimental Physiology, Volume 111, Issue 7, Page 3310-3321, 1 July 2026.
Abstract Lizards are renowned for their tremendous potential to heal tissues and organs after injury, but little is known about myocardial regeneration in reptiles generally. Here, we study cardiac regeneration in the leopard gecko (Eublepharis macularius) to fill the knowledge gap between traditional models of poikilothermic (zebrafish) and ...
Martina Gregorovicova, Barbora Sankova, Martin Bartos, Bjarke Jensen, Tobias Wang, David Sedmera   +5 more
wiley   +1 more source