Results 181 to 190 of about 48,590 (271)

Subtle changes in Purkinje cell firing in Purkinje cell-specific <i>Dyt1 ΔGAG</i> knock-in mice. [PDF]

Dystonia
Xing H, Girdhar P, Liu Y, Yokoi F, Vaillancourt DE, Li Y.   +5 more
europepmc   +1 more source

A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes

The Journal of Physiology, Volume 604, Issue 13, Page 5561-5584, 1 July 2026.
Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner, Fabio Frangiamore, Frédéric Sonak, Josef Madl, Thomas Seidel, Peter Kohl, Eva A. Rog‐Zielinska   +6 more
wiley   +1 more source

A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion of <i>Scn1b</i>. [PDF]

J Neurosci
Guillén FI, Geist MA, Cheng SY, Harris AM, Treviño ME, Nishiyama H, Brumback AC, Howard MA.   +7 more
europepmc   +1 more source

In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models

The Journal of Physiology, Volume 604, Issue 13, Page 5585-5609, 1 July 2026.
Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero, Jairo Rodríguez Padilla, Nicolas Cedilnik, Buntheng Ly, Juan F. Gomez, Maxime Sermesant, Mihaela Pop, Beatriz Trenor   +7 more
wiley   +1 more source

FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis. [PDF]

Nat Neurosci
Khouri-Farah N, Guo Q, Perry TA, Dussault R, Li JYH.   +4 more
europepmc   +1 more source

Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss. [PDF]

Front Mol Neurosci, 2023
Kapfhammer JP, Shimobayashi E.
europepmc   +1 more source

Temporal dynamics of Purkinje cell-intrinsic excitability governs cerebellar systems consolidation. [PDF]

iScience
Seo J, Kim YG, Lee YS, Kim SJ.
europepmc   +1 more source

Update of the risk assessment on emerging and novel brominated flame retardants in food

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The European Commission asked EFSA to update its 2012 risk assessment on Emerging and Novel brominated flame retardants (BFRs) in food. Since the previous Opinion, further information was collected for a total of 27 BFRs. The CONTAM Panel concluded that TDBPP, DBPNG and TBNPA are considered genotoxic and carcinogenic.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Emilio Benfenati, Diane Benford, Andy Hart, Martin Rose, Henri Schroeder, Christiane Vleminckx, Martine Vrijheid, Edoardo Carnesecchi, Violetta Costanzo, Andrea Gissi, Eirini Kouloura, Luisa Ramos Bordajandi, Francesca Riolo, Christer Hogstrand   +33 more
wiley   +1 more source

The ER/Golgi Protein FNDC3B Facilitates Climbing Fibre to Purkinje Cell Synapse Elimination in the Developing Mouse Cerebellum. [PDF]

Eur J Neurosci
Mercier CL, Watanabe T, Okuno Y, Matsuyama K, Kushibe K, Denny H, Miyazaki T, Yamasaki M, Kawamura M, Abe M, Sakimura K, Watanabe M, Uesaka N, Kano M.   +13 more
europepmc   +1 more source

Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice. [PDF]

Elife
Donofrio SG, Brandenburg C, Brown AM, Lin T, Lu HC, Sillitoe RV.   +5 more
europepmc   +1 more source