Results 171 to 180 of about 12,040,588 (301)

FTLD‐TDP‐43 With Motor Neuron Disease Pathology in an Autopsied Patient With Spastic Paraplegia‐30B Harbouring a Homozygous KIF1A Variant

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
KIF1A‐associated neurological disorder (KAND) is a rare hereditary condition caused by KIF1A variants, affecting axonal transport and presenting with a wide clinical spectrum, including hereditary spastic paraplegia. This case of childhood‐onset KAND reveals FTLD‐TDP43 with motor neuron disease pathology emerging late in the disease course, suggesting ...
Rie Saito, Arika Hasegawa, Tetsuya Takahashi, Ryoko Koike, Norikazu Hara, Ramil Gabdulkhaev, Kishin Koh, Akio Kawakami, Yoshihisa Takiyama, Takeshi Ikeuchi, Akiyoshi Kakita   +10 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Temporal learning in the cerebellum: The microcircuit model [PDF]

The cerebellum is that part of the brain which coordinates motor reflex behavior. To perform effectively, it must learn to generate specific motor commands at the proper times.
Miles, Coe F., Rogers, David
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, Volume 13, Issue 5, Page 1005-1019, May 2026.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Hominoid‐specific calretinin‐immunopositivity of the optic radiation (geniculocalcarine tract)

The Anatomical Record, Volume 309, Issue 5, Page 1343-1367, May 2026.
Calretinin‐immunostained coronal section through the primary (V1) and extrastriate (ExSt) cortex of the lar gibbon. Note that the optic radiation (OR) is strongly calretinin‐immunoreactive. This calretinin‐immunopositivity of the OR distinguishes the Hominoidea from other primates in terms of the neurochemistry of the OR.
Nelyane N. M. Santana, Jordan Swiegers, Mads F. Bertelsen, Chet C. Sherwood, José R. L. P. Cavalcanti, Paul R. Manger   +5 more
wiley   +1 more source

Mutation in RNF170 Causes Unsteady Gait with Hypertrophic Olivary Degeneration

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Hypertrophic olivary degeneration (HOD) is a rare form of transsynaptic degeneration resulting from disruption of the Guillain–Mollaret triangle, typically presenting with palatal tremor, ataxia, and nystagmus. Mutations in the Ring Finger Protein 170 (RNF170) gene have been associated with autosomal dominant sensory ataxia.
Change Wang
wiley   +1 more source

Age‐Related Low Frequency Amplitude Differences in Resting‐State Blood Oxygenation Level‐Dependent Signal in the Cerebellum

Human Brain Mapping, Volume 47, Issue 7, May 2026.
This study found that fractional amplitude of low frequency fluctuations in cerebellar Crus I/II is significantly greater in older adults as compared to younger adults. The higher amplitude in this region is associated with increased connectivity to cortical regions, and may be characteristic of healthy aging.
Jessica A. Korte, Christopher J. Steele, Wilsaan M. Joiner, Audrey P. Fan   +3 more
wiley   +1 more source

Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia. [PDF]

Front Cell Neurosci
Shi Q, Taylor AM, Sell LB, Bhat MA.
europepmc   +1 more source

Purkinje cell models

Frontiers in Computational Neuroscience
The investigation of the dynamics of Purkinje cell (PC) activity is crucial to unravel the role of the cerebellum in motor control, learning and cognitive processes. Within the cerebellar cortex (CC), these neurons receive all the incoming sensory and motor information, transform it and generate the entire cerebellar output.
Fernández Santoro, Elías Mateo, Karim, Arun, Warnaar, Pascal, De Zeeuw, Chris I., Badura, Aleksandra, Negrello, Mario   +5 more
openaire   +1 more source

Cerebellar purkinje cell dysfunction contributes to gait impairments in Shank3-mutant mice. [PDF]

Mol Autism
Liu H, Huang X, Ma G, Zhao X, Xia R, Li Z, Guo B, Wu S, Wang W.   +8 more
europepmc   +1 more source