Results 171 to 180 of about 5,279,387 (270)

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai, Mengquan Tan, Man Yuan, Huixian Zhou, Qin Xie, Jiling Zeng, Yixin Yang, Xinran He, Siyuan Song   +8 more
wiley   +1 more source

Steady-state Purkinje cell activity has limited predictive power for cerebellar output in disease. [PDF]

J Physiol
Lyon AM, Hernandez-Castanon V, van der Heijden ME.   +2 more
europepmc   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2405-2418, October 2026.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Purkinje Cell Collaterals Preferentially Target a Subtype of Molecular Layer Interneuron. [PDF]

J Neurosci
Lackey EP, Norton A, Moreira L, Gaynor CS, Lee WA, Regehr WG.   +5 more
europepmc   +1 more source

Driving Cerebellar Theta Oscillations Interferes With Voluntary Neck Movements in Cervical Dystonia

Movement Disorders, Volume 41, Issue 10, Page 2688-2698, October 2026.
Abstract Background Cervical dystonia (CD) is a movement disorder with a complex pathophysiology, including cerebellar abnormalities. Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique capable of entraining brain oscillations, can transiently modulate neuronal activity and enhance resonant rhythms.
Davide Costa, Andrea Guerra, Daniele Birreci, Massimiliano Passaretti, Martina De Riggi, Anna Sofia Grandolfo, Valentina D'Onofrio, Luca Angelini, Giulia Paparella, Matteo Bologna   +9 more
wiley   +1 more source

Purkinje Cell Loss and Changes in Basket Cell Morphology in Essential Tremor and Other Cerebellar Degenerative Diseases: A Postmortem Study of 332 Brains. [PDF]

Cerebellum
Wainman E, Guy TO, Hernandez N, Faust PL, Louis ED.   +4 more
europepmc   +1 more source

The Role of Dendritic Spines in Water Exchange Measurements With Diffusion MRI: Time‐Dependent Single Diffusion Encoding MRI

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Geometric exchange between dendritic spines and shafts is often neglected, yet it exhibits the same signature as permeative exchange, biasing NEXI/SMEX measurements. We propose two models: an extended three‐compartment Kärger model that resolves spine–shaft exchange explicitly, and a coarse‐grained Kärger model that absorbs spines into an effective ...
Kadir Şimşek, Arthur Chakwizira, Markus Nilsson, Marco Palombo   +3 more
wiley   +1 more source

Climbing fibres recruit disinhibition to enhance Purkinje cell calcium signals. [PDF]

Nature
Santos-Valencia F, Lackey EP, Norton A, Wardak A, Gaynor CS, Ediger S, Hemelt ME, Nguyen TM, Lee WA, Brunel N, Hull CA, Regehr WG.   +11 more
europepmc   +1 more source

Dizziness, Lower Limb Weakness, and Falls in COPD: A Prospective Longitudinal Pilot Study Using Monthly Home Diaries

Physiotherapy Research International, Volume 31, Issue 4, October 2026.
ABSTRACT Background and Purpose Falls affect approximately half of individuals with chronic obstructive pulmonary disease (COPD) and are associated with hospitalization, accelerated functional decline, and early institutionalization. Existing evidence suggests that single‐visit assessments have limited and inconsistent ability to predict the future ...
Danielle Ferreira de Santana Silva, Bianca Maria Santos Alcântara, Jefferson Ricardo Santos da Silva, Rafaela Pedrosa, Eduardo Eriko Tenório de França, José Heriston de Morais Lima   +5 more
wiley   +1 more source

Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1. [PDF]

J Clin Invest
Lee C, Grijalva RM, Tejwani L, Bae E, Chase A, Ro H, Kim H, Olmos V, Orengo JP, Lim J.   +9 more
europepmc   +1 more source