Results 171 to 180 of about 48,590 (271)

Purkinje cell-specific loss of Neurofascin and Ankyrin G causes disruption of axon initial segments, neurodegeneration, and cerebellar ataxia. [PDF]

Front Cell Neurosci
Shi Q, Taylor AM, Sell LB, Bhat MA.
europepmc   +1 more source

The cardiac pacemakers: A paradigm of robustness in evolutionary biology

The Journal of Physiology, Volume 604, Issue 13, Page 5159-5169, 1 July 2026.
Abstract figure legend Functional networks in living systems are formed by many thousands of gene products. In association with those networks, several genes (four in this diagram) may be sufficient, each on its own, to ensure that the function occurs. Any one of these may be removed or blocked while leaving the others to continue functioning.
Denis Noble
wiley   +1 more source

Cerebellar purkinje cell dysfunction contributes to gait impairments in Shank3-mutant mice. [PDF]

Mol Autism
Liu H, Huang X, Ma G, Zhao X, Xia R, Li Z, Guo B, Wu S, Wang W.   +8 more
europepmc   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, Volume 604, Issue 13, Page 5170-5199, 1 July 2026.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Cerebellar Purkinje cell firing reduction contributes to aging-related declining motor coordination in mice. [PDF]

Proc Natl Acad Sci U S A
Fields E, Rogers BC, Leung TCS, Huang A, Kern M, Kontowicz N, Dolin H, Watt AJ.   +7 more
europepmc   +1 more source

Uncertainty quantification via polynomial chaos expansion of myocardial fibre orientation and cardiac activation patterns

The Journal of Physiology, Volume 604, Issue 13, Page 5440-5457, 1 July 2026.
Abstract figure legend Graphical representation of methods. We implemented three biventricular geometric models (Zenger et al., 2020) with rule‐based myocardial fibre orientations (Bayer et al., 2018). We evaluated variability in the fibre orientation via four sets of parameter distributions to determine the role of the primary and imbrication angles ...
Lindsay C. R. Tanner, Anna Busatto, Jake A. Bergquist, Wilson W. Good, Brian Zenger, Gernot Plank, Akil Narayan, Karli Gillette, Rob S. MacLeod   +8 more
wiley   +1 more source

Purkinje cell activity changes in cerebellar subregions during fear conditioning. [PDF]

Front Behav Neurosci
Pakusch J, Nair T, Grosch T, Mark MD.
europepmc   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, Volume 604, Issue 13, Page 5276-5295, 1 July 2026.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source

E3 ligase AREL1 controls perinuclear localization of lysosomes and supports Purkinje cell survival. [PDF]

EMBO J
Jiang L, Tang J, Zhang YF, Zou WX, Deng G, Tian N, Zhao X, Han L, Liu K, Song BL, Luo J.   +10 more
europepmc   +1 more source

The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability

The Journal of Physiology, Volume 604, Issue 13, Page 5260-5275, 1 July 2026.
Abstract figure legend We investigated the age‐ and sex‐related differences in the apicobasal repolarization gradient (ABRG) and evaluated their possible role inventricular arrhythmia vulnerability. Electrocardiographic imaging (ECGI) was performed in healthy subjects during sinus rhythm, and the average recovery time (RT) and activation–recovery ...
Vladimír Sobota, Job Stoks, Kiran Haresh Kumar Patel, Roshni Shetty, Haibo Ni, Eleonora Grandi, Fu Siong Ng, Paul G. A. Volders, Matthijs J. M. Cluitmans, Jason D. Bayer   +9 more
wiley   +1 more source