Results 111 to 120 of about 48,590 (271)

Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival [PDF]

, 2011
A major problem of ageing is progressive impairment of neuronal function and ultimately cell death. Since sex steroids are neuroprotective, their decrease with age may underlie age-related neuronal degeneration.
Bakouche, Joelle, Janmaat, Sonja, Janmaat, Sonja,, Sherrard, Rachel M.,, Yvette Akwa, Mariani, Jean, Pianos, Antoine,, Frédéric, Florence,, Joëlle Bakouche, Jean Mariani, Liere, Philippe,, Sonja Janmaat, Antoine Pianos, Baulieu, Etienne-Emile,, Philippe Liere, Groothuis, Ton,, Florence Frédéric, Akwa, Yvette,, Bernard Eychenne, Luiten, Paul,, Paul Luiten, Liere, Philippe, Bakouche, Joëlle,, Vanessa Gautheron, Gautheron, Vanessa,, Frederic, Florence, Akwa, Yvette, Baulieu, Etienne-Emile, Eychenne, Bernard, Doulazmi, Mohamed,, Mohamed Doulazmi, Pianos, Antoine, Groothuis, Ton, Sherrard, Rachel M, Mariani, Jean,, Etienne-Emile Baulieu, Rachel M. Sherrard, Doulazmi, Mohamed, Ton Groothuis, Eychenne, Bernard,, Sherrard, Rachel M., Gautheron, Vanessa, Luiten, Paul   +42 more
core   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cell differentiation [PDF]

, 2022
Pontocerebellar hypoplasias (PCHs) are congenital disorders characterized by hypoplasia or early atrophy of the cerebellum and brainstem, leading to a very limited motor and cognitive development.
Moutton, Sebastien, Cantagrel, Vincent, Moreno, Nadjeda, Barcia, Giulia, Altin, Nami, Al-Thihli, Khalid, Baptista, Julia, Rausell, Antonio, Rajamani, Karthyayani, Lombardi, Emilia Puig, Yvert, Marianne, Boddaert, Nathalie, Gelot, Antoinette, Afenjar, Alexandra, Al-Maawali, Almundher, Garel, Catherine, Siquier-Pernet, Karine, De Villemeur, Thierry Billette, Legendre, Marine, Beleza-Meireles, Ana, Burglen, Lydie, Nitschke, Patrick, Pereira, Eva, Laquerriere, Annie, Coolen, Marion, Razavi, Ferechte, Pouliet, Aurore   +26 more
core  

Biosynthesis, mode of action and functional significance of neurosteroids in the Purkinje cell

Frontiers in Endocrinology, 2011
The brain has traditionally been considered to be a target site of peripheral steroid hormones. In addition to this classical concept, we now know that the brain has the capacity to synthesize steroids de novo from cholesterol, the so-called ...
Kazuyoshi eTsutsui, Kazuyoshi eUkena, Hirotaka eSakamoto, Shin-ichiro eOkuyama, Shogo eHaraguchi   +4 more
doaj   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Decoding of Purkinje cell pauses by deep cerebellar nucleus neurons [PDF]

, 2009
The recognition of parallel fibre (PF) input patterns by Purkinje cells has been suggested to underlie cerebellar learning [1,2]. A candidate mechanism for the recognition of PF patterns is the long-term depression (LTD) of the PF synapses that is ...
Davey, N., Maex, Reinoud, Steuber, Volker, Luthman, Johannes, Adams, Roderick   +4 more
core   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

Brain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich, David S. Priemer, Charles Harker Rhodes, Daniel P. Perl, Kurenai Tanji, James E. Goldman   +5 more
wiley   +1 more source

A new approach for determining phase response curves reveals that Purkinje cells can act as perfect integrators.

PLoS Computational Biology, 2010
Cerebellar Purkinje cells display complex intrinsic dynamics. They fire spontaneously, exhibit bistability, and via mutual network interactions are involved in the generation of high frequency oscillations and travelling waves of activity.
Elena Phoka, Hermann Cuntz, Arnd Roth, Michael Häusser   +3 more
doaj   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source