Results 91 to 100 of about 48,590 (271)
Human aldolase C: gene transcriptional regulation and protein functional role [PDF]
, 2011 Aldolase C is the brain-specific aldolase isoenzyme. In the human brain, aldolase C messenger and protein are expressed in a stripe-like pattern in the Purkinje cells of the cerebellum, in the inferior olives and in the Goll and Burdach nuclei of the ...
Serio, Laura
core
Purkinje cells and their trees
The Lancet Neurology, 2021 Zoghbi, Huda Y, Mehta, Arpan R
openaire +4 more sources
Journal of Intelligent Medicine, EarlyView.Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley +1 more source
Dendritic spike induction of postsynaptic cerebellar LTP [PDF]
, 2008 The architecture of parallel fiber (PF) axons contacting cerebellar Purkinje neurons (PNs) retains spatial information over long distances. PF synapses can trigger local dendritic calcium spikes, but whether and how this calcium signal leads to plastic ...
Marco Canepari, Kaspar E. Vogt
core +1 more source
Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant [PDF]
, 2003 Heterokaryons are the product of cell fusion without subsequent nuclear or chromosome loss. Decades of research using Sendai-virus or polyethylene glycol (PEG)-mediated fusion in tissue culture showed that the terminally differentiated state of a cell ...
James M. Weimann +7 more
core +1 more source
Recent Advances in Top‐Down Proteomics for Single‐Cell Research
Mass Spectrometry Reviews, EarlyView.ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley +1 more source
Regularity, variabilty and bi-stability in the activity of cerebellar Purkinje cells
Frontiers in Cellular Neuroscience, 2009 Recent studies have demonstrated that the membrane potential of Purkinje cells is bi-stable and that this phenomenon underlies bi-modal simple spike firing.
Dan Rokni +3 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Variants in AFG3‐Like Matrix AAA Peptidase, Subunit 2 (AFG3L2) gene are associated with diverse clinical phenotypes. Here, we describe phenotypic findings of two unrelated children with de novo heterozygous variant and one family with inherited heterozygous variant in AFG3L2 gene.
Sangeetha Yoganathan +14 more
wiley +1 more source
Neurosteroid Biosynthesis and Action in the Purkinje Cell
Journal of Experimental Neuroscience, 2009 It is now clearly established that steroids can be synthesized de novo by the vertebrate brain. Such steroids are called neurosteroids. To understand neurosteroid action in the brain, data on the regio- and temporal-specific synthesis of neurosteroids ...
Kazuyoshi Tsutsui
doaj +1 more source