Results 101 to 110 of about 5,862,696 (348)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Femininity Aspect as Reflected in Lisa See\u27s Snow Flower and the Secret Fan [PDF]

open access: yes, 2018
The purpose of this study is to describe forms opression faced by Chinese women in the nineteenth century as reflected in te novel “Snow Flower and the Secret Fan” written by Lisa See, then to find out the way of the Chinese women to minimize their ...
Rakhmyta, Y. A. (Yunie)
core  

Cosmopolitanism and Human Reason [PDF]

open access: yes, 2019
Over and above the modalities with which it is expressed in the domains of Kant’s system, the theme of cosmopolitanism embodies the meaning of a philosophy seen as a plan to build on the connection between man, polis and reason; an essential connection ...
cicatello a
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Prayer, personality and purpose in life : an empirical enquiry among adolescents in the UK [PDF]

open access: yes, 2016
The linkage between religion and purpose in life is a matter of theoretical interest within the two fields of empirical theology and psychology of religion.
Francis, Leslie J., Penny, Gemma
core  

Cosmic explosions, life in the Universe and the Cosmological Constant

open access: yes, 2016
Galactic Gamma-Ray Bursts (GRBs) are copious sources of gamma-rays that can pose a threat to complex life. Using recent determinations of their rate and the probability of GRBs causing massive extinction, we explore what type of universes are most likely
Cuesta, Antonio J.   +4 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Meaning in Life and Psychological Weil-Being in Spanish Emerging Adults

open access: yesActa Colombiana de Psicología
Experiencing meaning in life (MiL) and psychological well-being (PWB) is an important developmental task in emerging adulthood, perhaps more than in any other period in life due to its transitional character and to the nature of its features, in Western ...
Joaquín García-Alandete   +3 more
doaj   +1 more source

Meaning in Life of Medical Sciences Students During COVID-19 Outbreak: A Cross-sectional Study

open access: yesعلوم بهداشتی ایران, 2022
Background and Purpose: The outbreak of coronavirus and its subsequent conditions have affected the mental health of students. One of the variables related to mental health is “meaning in life.” It enables students to endure sorrows and hardships to ...
Seyyed Muhammad Mahdi Mahdavinoor   +2 more
doaj  

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