Results 181 to 190 of about 5,892,314 (307)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Relationships Between Religiosity, Self-Esteem, and Purpose in Life

Spirituality Studies
This exploratory study analyzes whether self-esteem and religiosity influence life purpose. A questionnaire was used in which there are three scales: Purpose of Life (García-Alandete, Martínez and Nohales 2013; PIL-10 with Cronbach’s alpha score=.904 ...
Carmen María Salvador-Ferrer
doaj  

Positive youth predictors of purpose in life in Peruvian university students. [PDF]

BMC Psychol
Rojas Zegarra ME, Pérez-Díaz PA, Yana Calla VR, Vilca-Pareja V, Ardiles-Irarrázabal RA, Muñoz-Del-Carpio-Toia A.   +5 more
europepmc   +1 more source

Sense of Purpose in Life and Beliefs and Knowledge of Alzheimer's Disease. [PDF]

Arch Clin Neuropsychol, 2023
Sutin AR, Stephan Y, Luchetti M, Aschwanden D, Sesker AA, Zhu X, Terracciano A.   +6 more
europepmc   +1 more source

HUMAN PURPOSE IN LIFE

Zygon: Journal of Religion and Science, 1966
openaire   +1 more source

Purposiveness in Nature and Life [PDF]

Monist, 1914
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Purpose in life and concurrent and incident fatigue. [PDF]

Psychol Health Med
Sutin AR, Hajek A, Luchetti M, Stephan Y, Terracciano A.   +4 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Purpose in Life and Estimated Type 2 Diabetes Risk: Cross-Sectional Associations Across Three Validated Risk Scores in 93,077 Spanish Working Adults. [PDF]

Med Sci (Basel)
García Pertegaz P, Tárraga López PJ, Coll Campayo I, Busquets-Cortés C, López-González ÁA, Ramírez-Manent JI.   +5 more
europepmc   +1 more source