Results 131 to 140 of about 167,574,678 (311)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

List of town school committees, boards of school visitors, boards of education; List of town school committees, boards of school visitors, boards of education, library directors; Directory of Connecticut public school officials

, 1951
Vols. for 19-44 issued as Connecticut school document.; Two vols. issued as 1909 ( Mar. 1909, Dec. 1909); no vol. 1908 published?; Vols.
Connecticut. State Department of Education.
core  

Influence of Baffle Location on the Diodicity of Tesla Valves

Applied Sciences
The Tesla valve (TV) is a valvular conduit that allows fluid to flow in one direction while restricting flow in the opposite direction, making it useful for enhancing fluid control in the field of microfluidics.
Shengyu Zhu, Pengfei Wang, Li Liu, Chuan Ding   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A superior education for Connecticut's 21st century learners : - five-year comprehensive plan, 2006-2011.

, 2007
"Adopted by the Connecticut State Board of Education on January 3, 2007"--Cover.; Previously published: Greater expectations : Connecticut's comprehensive plan for education, 2001-2005.
Connecticut. State Board of Education.
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Annual Report of the Department of Education

, 1953
Annual Report of the Department of Education, 1953-1955Letter of transmittal -- Personnel of department -- Part I annual report -- Statistical tables related to elementary and secondary education -- Public examinations -- Audio visual education ...
Newfoundland. Department of Education
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A Decrease in Branched-Chain Amino Acids after a Competitive Male Professional Volleyball Game—A Metabolomic-Based Approach

Metabolites
A competitive volleyball game is a highly metabolic and physically demanding event for professional players. This study aimed to investigate whether a single game at the end of a preseason promotes changes in the biochemical markers of physical exercise ...
Taillan Martins Oliveira, Tathiany Jéssica Ferreira, Paula Albuquerque Penna Franca, Rudson Ribeiro da Cruz, Mauricio Gattás Bara-Filho, Fábio Luiz Candido Cahuê, Ana Paula Valente, Anna Paola Trindade Rocha Pierucci   +7 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source