α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Prescription stimulant consumption in the United States compared with 35 other countries. [PDF]
Bachhuber MA, Jordan AE, Piper BJ.
europepmc +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
English for professional academic purposes: writing for scholarly publication
English is now unquestionably the language of international scholarship and an important medium of research communication for non-native English speaking academics around the world.
Hyland, Ken, Hyland, KL
core
Dual-use, quantum technologies, and responsible innovation: the challenges of responsible quantum in defence. [PDF]
Ten Holter C, Wolf-Bauwens M.
europepmc +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Terminological Recognition in French for Specific Purposes
Recognition of terminology is an essential cognitive activity for learners of languages for specific purposes and presents particular difficulties compared to general lexical recognition.
Matesanz del Barrio, María +1 more
core
Using Ultra-Abridged Individual Difference Scales for Personalization in Digital Mental Health to Improve Uptake, Engagement, and Experiences: Three-Tiered Decision Framework for Scale Shortening. [PDF]
Yeung SK, Tong ACY, Zhao H, Mak WWS.
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source

