Results 141 to 150 of about 130,655 (306)

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, Volume 100, Issue S4, Page 30-50, June 2025.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

PURPURA OF THE BLADDER [PDF]

, 1913
Frank Kidd
openalex   +1 more source

Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A

Applied Research, Volume 4, Issue 3, June 2025.
The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury, Alexander Röntgen, Matthew Greenig, Yanira Méndez Gómez, Sebastian P. Spiegel, Magdalena Nowinska, Aubin Ramon, Pietro Sormanni, Andrew Chan, Michele Vendruscolo   +9 more
wiley   +1 more source

Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures

Cell Reports
Summary: Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal circuit function is fine-tuned upon activity.
Kaoutsar Nasrallah, Coralie Berthoux, Yuki Hashimotodani, Andrés E. Chávez, Michelle C. Gulfo, Rafael Luján, Pablo E. Castillo   +6 more
doaj  

Regenerative fibroblasts derived from autologous skin tissue for the treatment of Sjögren’s syndrome: a case report

Frontiers in Immunology
BackgroundSjögren’s syndrome (SS) is a systemic autoimmune disease, with major symptoms including dry mouth and dry eyes, for which there is no effective treatment.
Zhao-Xia Ma, Xing-Fei Wu, Li Cao, Cheng-Yan Jiao, Dai-Ping Ma, Yun-Hui Zhao, Zhi-Xing Yang, Min Hu, Min Hu   +8 more
doaj   +1 more source

A Red Skin in the Setting of Chickenpox: A Rare Report of Eosin Toxicity

Clinical Case Reports, Volume 13, Issue 6, June 2025.
ABSTRACT Eosin Yellowish (Eosin‐Y) is an effective treatment option for a range of dermatological conditions. It is crucial to carefully identify patients presenting systemic adverse reactions related to topical aqueous Eosin‐Y overuse and to monitor them closely during short‐term use to prevent severe complications.
Bahareh Abtahi‐Naeini, Fereshte Rastegarnasab, Zahra Pourmoghaddas, Shadi Asad Samani, Saeed Yousefian, Zahra‐Sadat Mirian   +5 more
wiley   +1 more source

The Schonlein-Henoch Syndrome (Anaphylactoid Purpura) Compared with Certain Features of Nephritis and Rheumatism [PDF]

, 1955
Ian Lewis
openalex   +1 more source

Moisturizing Treatment Outcomes: A Comparative Study of Diabetic and Nondiabetic Skin, Associated With the Presence or Absence of Dermatoporosis

Dermatological Reviews, Volume 6, Issue 3, June 2025.
ABSTRACT Background Skin disorders are highly common in type 1 and 2 diabetes mellitus patients. This study assessed the effects of a moisturizing formulation on photoprotected (volar forearm) and photoexposed (dorsal hand) skin in diabetic and nondiabetic participants, with or without stage I dermatoporosis, comparing it to a reference product ...
Juliana Rodrigues Pinto, Silas Arandas Monteiro e Silva, Gislaine Ricci Leonardi   +2 more
wiley   +1 more source

Linking preclinical models to clinical realities: VEGF/VEGFR inhibitors and thrombotic microangiopathy in cancer therapy

iMetaOmics, Volume 2, Issue 2, June 2025.
This study investigates the risk of thrombotic microangiopathy (TMA) induced by vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) inhibitors in cancer therapy. Using data from the FDA Adverse Event Reporting System (FAERS), the WHO Global Database for Adverse Drug Reactions (Vigibase), and The Cancer ...
Aimin Jiang, Zhanzhi Li, Ying Liu, Junyi Shen, Quan Cheng, Anqi Lin, Peng Luo, Linhui Wang   +7 more
wiley   +1 more source

NOTE ON THE RELATION OF THE CAPILLARY BLOOD-VESSELS IN PURPURA. [PDF]

, 1909
William Osler
openalex   +1 more source