Results 41 to 50 of about 888,620 (301)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Oculomotor atypicalities in motor neurone disease: a systematic review

Frontiers in Neuroscience
IntroductionCognitive dysfunction is commonplace in Motor Neurone Disease (MND). However, due to the prominent motor symptoms in MND, assessing patients’ cognitive function through traditional cognitive assessments, which oftentimes require motoric ...
Megan Rose Readman, Megan Rose Readman, Megan Rose Readman, Megan Polden, Megan Polden, Megan Polden, Melissa C. Gibbs, Aisling Donohue, Suresh K. Chhetri, Trevor J. Crawford   +9 more
doaj   +1 more source

Effect of Prior Direction Expectation on the Accuracy and Precision of Smooth Pursuit Eye Movements

Frontiers in Systems Neuroscience, 2019
The integration of sensory with top–down cognitive signals for generating appropriate sensory–motor behaviors is an important issue in understanding the brain’s information processes.
Seolmin Kim, Seolmin Kim, Jeongjun Park, Jeongjun Park, Joonyeol Lee, Joonyeol Lee   +5 more
doaj   +1 more source

Smooth Pursuit Target Speeds and Trajectories [PDF]

Proceedings of the 17th International Conference on Mobile and Ubiquitous Multimedia, 2018
In this paper we present an investigation of how the speed and trajectory of smooth pursuits targets impact on detection rates in gaze interfaces. Previous work optimized these values for the specific application for which smooth pursuit eye movements were employed. However, this may not always be possible. For example UI designers may want to minimize
Heiko Drewes, Mohamed Khamis, Florian Alt   +2 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Vertical smooth pursuit as a diagnostic marker of traumatic brain injury

Concussion, 2020
Aim: Neural deficits were measured via the eye tracking of vertical smooth pursuit (VSP) as markers of traumatic brain injury (TBI).
Melissa Hunfalvay, Claire-Marie Roberts, Nicholas P Murray, Ankur Tyagi, Kyle W Barclay, Takumi Bolte, Hannah Kelly, Frederick R Carrick   +7 more
doaj   +1 more source

Emergence of Smooth Pursuit using Chaos [PDF]

First International Conference on Self-Adaptive and Self-Organizing Systems (SASO 2007), 2007
The task of tracking an object has been fully studied and many solutions presented before. However, it is a perfect test bed for the study of a novel model using Coupled Chaos Systems. Once an object appears in front of a camera, we demonstrate that the visual input is enough for the self-organization of the torques applied to each of the axes ...
B. DURAN, SANDINI, GIULIO, METTA, GIORGIO   +2 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Calibration-free gaze interfaces based on linear smooth pursuit

Journal of Eye Movement Research, 2020
Since smooth pursuit eye movements can be used without calibration in spontaneous gaze interaction, the intuitiveness of the gaze interface design has been a topic of great interest in the human-computer interaction field.
Zhe Zeng, Felix Wilhelm Siebert, Antje Christine Venjakob, Matthias Roetting   +3 more
doaj   +1 more source

Abnormalities of smooth pursuit in Parkinson’s disease: A systematic review

Clinical Parkinsonism & Related Disorders, 2021
Smooth pursuit eye movement (SPEM) abnormalities are commonly seen in Parkinson’s disease (PD). Both reduced speed and saccades seen during SPEM, also known as saccadic pursuit (SP), have been studied in PD.
Karen Frei
doaj   +1 more source