Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang +12 more
wiley +1 more source
Big Push versus Absorptive Capacity: How to Reconcile the Two Approaches [PDF]
In this paper we examine whether absorptive capacity can constitute sufficient justification for rejecting the proposal of a large aid increase to support the ?big push?.
Guillaumont, Patrick +1 more
core
Biomechanical assessment of polyaxial combination-hole locking plates for screw push-out strength and three-point bending. [PDF]
Losey B, Maritato K.
europepmc +1 more source
Understanding Operando Water Management in Hydroxide‐Exchange‐Membrane Fuel Cells
Effective water management is vital for high‐performance hydroxide‐exchange‐membrane fuel cells. Using a custom water‐flux station, this study quantifies how membrane thickness, microporous layers, and operating conditions dictate internal water transport.
Catherine M. Weiss +4 more
wiley +1 more source
Accentuated Eccentric Loading Increases Maximal Countermovement Jump Height Without Changes in Overall Lower Limb Kinetics and Energetics. [PDF]
Su EY +3 more
europepmc +1 more source
The article overviews past and current efforts on caloric materials and systems, highlighting the contributions of Ames National Laboratory to the field. Solid‐state caloric heat pumping is an innovative method that can be implemented in a wide range of cooling and heating applications.
Agata Czernuszewicz +5 more
wiley +1 more source
Clinical Decision-Making in Peptic Esophageal Stenosis: To PEG or Not to PEG? [PDF]
Cokovic JB, Prinz C, Fehring L.
europepmc +1 more source
Eutectic Gallium‐Indium as a Potential Non‐Toxic Replacement in Mercury Intrusion Porosimetry
A practical alternative to mercury intrusion porosimetry is presented using non‐oxidized eutectic gallium‐indium. An eGaIn Filling Station enables oxygen‐free preparation of standard penetrometers, and the resulting measurements faithfully reproduce pore‐size distributions and intrusion volumes measured with mercury across several standard reference ...
Denis Schuetz +8 more
wiley +1 more source
The reliability and measurement error of the movement quality assessment for athletes. [PDF]
Wijekulasuriya GA +3 more
europepmc +1 more source
3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi +4 more
wiley +1 more source

