Results 21 to 30 of about 194,643 (257)

Current management of generalized pustular psoriasis

Experimental Dermatology, 2023
Generalized pustular psoriasis (GPP) is a rare subset of psoriasis involving episodes of sterile pustules accompanied by inflammation and, often, systemic involvement.
N. Kodali, Isabella Blanchard, Sruthi Kunamneni, M. Lebwohl   +3 more
semanticscholar   +1 more source

“Autoinflammatory psoriasis”—genetics and biology of pustular psoriasis [PDF]

, 2021
Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations. Plaque psoriasis, which is the most common manifestation of psoriasis, is located on one end of the spectrum, dominated by adaptive immune ...
Ward, Nicole L, Harms, Paul W, Wang, Bo, Gudjonsson, Johann E, Maverakis, Emanual, Michelle Kahlenberg, J, Tsoi, Lam C, Billi, Allison C, Uppala, Ranjitha   +8 more
core   +1 more source

Imsidolimab, an Anti-IL-36 Receptor Monoclonal Antibody for the Treatment of Generalised Pustular Psoriasis: Results from the Phase 2 GALLOP Trial.

British Journal of Dermatology, 2023
BACKGROUND Generalised pustular psoriasis (GPP) is a systemic inflammatory disease that can be severe, debilitating, and life-threatening. Uncontrolled activation of interleukin-36 (IL-36) pro-inflammatory activity may underlie the pathogenesis of GPP ...
R. Warren, A. Reich, A. Kaszuba, W. Placek, C. Griffiths, Jihao Zhou, B. Randazzo, P. Lizzul, J. E. Gudjonsson   +8 more
semanticscholar   +1 more source

Spesolimab for the Treatment of Generalized Pustular Psoriasis

Drugs, 2023
Generalized pustular psoriasis (GPP) is a rare but severe skin inflammatory disorder characterized by the eruption of widespread sterile neutrophilic pustules, often accompanied by systemic inflammation. Given its life-threatening potential, GPP requires
Diana Bernardo, D. Thaçi, T. Torres
semanticscholar   +1 more source

Clinical Course and Characteristics of Generalized Pustular Psoriasis

American Journal of Clinical Dermatology, 2022
Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening disease characterized by episodes of widespread sterile macroscopic pustules, with or without systemic inflammation and/or plaque psoriasis.
S. Choon, A. Navarini, A. Pinter
semanticscholar   +1 more source

Rapid and sustained improvements in GPPGA scores with spesolimab for treatment of generalized pustular psoriasis flares in the randomized, placebo-controlled Effisayil 1 study.

Journal of American Academy of Dermatology, 2023
BACKGROUND Effisayil 1 was a randomized, placebo-controlled study of spesolimab, an anti-IL-36 receptor antibody, in patients presenting with a generalized pustular psoriasis (GPP) flare.
B. Elewski, M. Lebwohl, M. Anadkat, Jonathan Barker, K. Ghoreschi, S. Imafuku, U. Mrowietz, Ling Li, M. Quaresma, C. Thoma, H. Bachelez   +10 more
semanticscholar   +1 more source

Treatment Options and Goals for Patients with Generalized Pustular Psoriasis

American Journal of Clinical Dermatology, 2022
Generalized pustular psoriasis (GPP) is a rare, severe neutrophilic skin disorder characterized by sudden widespread eruption of superficial sterile pustules with or without systemic inflammation.
J. Krueger, L. Puig, D. Thaçi
semanticscholar   +1 more source

Efficacy of spesolimab for the treatment of generalized pustular psoriasis flares across pre‐specified patient subgroups in the Effisayil 1 study

Experimental Dermatology, 2023
Effisayil 1 was a multicentre, randomized, double‐blind, placebo‐controlled study of the anti‐interleukin (IL)‐36 receptor monoclonal antibody, spesolimab, in patients presenting with a generalized pustular psoriasis (GPP) flare.
A. Burden, Y. Okubo, M. Zheng, D. Thaçi, P. V. D. van de Kerkhof, N. Hu, M. Quaresma, C. Thoma, S. Choon   +8 more
semanticscholar   +1 more source

Persistent Fever and Rising CRP in a Patient With Pustular Psoriasis Deceived the Medical Team to Consider Her as a Case of COVID-19 During the Pandemic

Acta Medica Iranica, 2021
Generalized pustular psoriasis is a rare variant of pustular psoriasis. During the pandemic of COVID-19, every patient referred to medical centers with fever or other flu-like symptoms would be first evaluated for COVID-19.
Zahra Saffarian, Shahin Hamzelou, Fateme Shirzad Moghadam   +2 more
doaj   +1 more source

Psychometric validation of the generalized pustular psoriasis physician global assessment (GPPGA) and generalized pustular psoriasis area and severity index (GPPASI)

Journal of the European Academy of Dermatology and Venereology, 2023
Generalized pustular psoriasis (GPP) is a rare and life‐threatening skin disease often accompanied by systemic inflammation. There are currently no standardized or validated GPP‐specific measures for assessing severity.
A. D. Burden, R. Bissonnette, M. Lebwohl, T. Gloede, M. Anatchkova, I. Budhiarso, N. Hu, C. Thoma, Anne M. Skalicky, H. Bachelez   +9 more
semanticscholar   +1 more source