Results 141 to 150 of about 5,350,859 (283)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

Proceedings of the National Academy of Sciences of the United States of America, 2009
J. Korbel, T. Tirosh-Wagner, A. Urban, Xiao-Ning Chen, Maya M Kasowski, Li Dai, Fabian Grubert, Chandra Erdman, Michael C. Gao, K. Lange, E. Sobel, G. Barlow, A. Aylsworth, N. Carpenter, R. Clark, M. Cohen, E. Doran, T. Falik-Zaccai, S. Lewin, I. Lott, B. McGillivray, J. Moeschler, M. Pettenati, S. Pueschel, K. Rao, L. Shaffer, M. Shohat, Alexander J Van Riper, D. Warburton, S. Weissman, M. Gerstein, M. Snyder, J. Korenberg   +32 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Poorly Differentiated Neuroendocrine Carcinomas of the Pancreas: A Clinicopathologic Analysis of 44 Cases

American Journal of Surgical Pathology, 2014
O. Basturk, Laura H. Tang, R. Hruban, V. Adsay, Zhaohai Yang, A. Krasinskas, E. Vakiani, S. La Rosa, K. Jang, W. Frankel, Xiuli Liu, Lizhi Zhang, T. Giordano, A. Bellizzi, Jey-Hsin Chen, C. Shi, P. Allen, D. Reidy, elliot k fishman, B. Saka, N. Rezaee, V. Deshpande, D. Klimstra   +22 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Kinematics of the local universe - VII. New 21-cm line measurements of 2112 galaxies

, 1998
G. Theureau, L. Bottinelli, N. Coudreau-Durand, L. Gouguenheim, N. Hallet, M. Loulergue, G. Paturel, P. Teerikorpi   +7 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Revision-free reverse shoulder arthroplasty patients report greater difficulty with some activities of daily living compared to anatomic total shoulder arthroplasty patients at mid-term follow-up. [PDF]

Shoulder Elbow
Molokwu BO, Xu JJ, Farrell SG, Perry A, Roche CP, Virk MS, Zuckerman JD, Yao JJ.   +7 more
europepmc   +1 more source